65 research outputs found
Solid like friction of a polymer chain
We propose a simple friction model for isolated polymer chains on a solid
substrate. The chains are pulled at constant velocity by one end, the other end
can be trapped on the solid substrate on localised sites. We focus on the
energy dissipation due to the traps. This simple model leads to non trivial
friction laws, depending on the velocity and the distance between traps. Some
refinements of the model such as the effect of thermal fluctuation are also
reported.Comment: 16 pages, 4 eps figures, accepted for publuication in Eur. Phys. J. E
New version of 20/07/2000 minor modifications to figure
Comment on `About the magnetic field of a finite wire'
A flaw is pointed out in the justification given by Charitat and Graner [2003
Eur. J. Phys. vol. 24, 267] for the use of the Biot--Savart law in the
calculation of the magnetic field due to a straight current-carrying wire of
finite length.Comment: REVTeX, 3 pages. A slightly expanded version that has been accepted
for publication by Eur. J. Phy
Scattering from Solutions of Star Polymers
We calculate the scattering intensity of dilute and semi-dilute solutions of
star polymers. The star conformation is described by a model introduced by
Daoud and Cotton. In this model, a single star is regarded as a spherical
region of a semi-dilute polymer solution with a local, position dependent
screening length. For high enough concentrations, the outer sections of the
arms overlap and build a semi-dilute solution (a sea of blobs) where the inner
parts of the actual stars are embedded. The scattering function is evaluated
following a method introduced by Auvray and de Gennes. In the dilute regime
there are three regions in the scattering function: the Guinier region (low
wave vectors, q R << 1) from where the radius of the star can be extracted; the
intermediate region (1 << q R << f^(2/5)) that carries the signature of the
form factor of a star with f arms: I(q) ~ q^(-10/3); and a high wavevector zone
(q R >> f^(2/5)) where the local swollen structure of the polymers gives rise
to the usual q^(-5/3) decay. In the semi-dilute regime the different stars
interact strongly, and the scattered intensity acquires two new features: a
liquid peak that develops at a reciprocal position corresponding to the
star-star distances; and a new large wavevector contribution of the form
q^(-5/3) originating from the sea of blobs.Comment: REVTeX, 12 pages, 4 eps figure
Effect of an electric field on a floating lipid bilayer: a neutron reflectivity study
We present here a neutron reflectivity study of the influence of an
alternative electric field on a supported phospholipid double bilayer. We
report for the first time a reproducible increase of the fluctuation amplitude
leading to the complete unbinding of the floating bilayer. Results are in good
agreement with a semi-quantitative interpretation in terms of negative
electrostatic surface tension.Comment: 12 pages, 7 figures, 1 table accepted for publication in European
Physical Journal E Replaced with with correct bibliograph
Self healing slip pulses along a gel/glass interface
We present an experimental evidence of self-healing shear cracks at a
gel/glass interface. This system exhibits two dynamical regimes depending on
the driving velocity : steady sliding at high velocity (> Vc = 100-125 \mu
m/s), caracterized by a shear-thinning rheology, and periodic stick-slip
dynamics at low velocity. In this last regime, slip occurs by propagation of
pulses that restick via a ``healing instability'' occuring when the local
sliding velocity reaches the macroscopic transition velocity Vc. At driving
velocities close below Vc, the system exhibits complex spatio-temporal
behavior.Comment: 4 pages, 6 figure
From supported membranes to tethered vesicles: lipid bilayers destabilisation at the main transition
We report results concerning the destabilisation of supported phospholipid
bilayers in a well-defined geometry. When heating up supported phospholipid
membranes deposited on highly hydrophilic glass slides from room temperature
(i.e. with lipids in the gel phase), unbinding was observed around the main gel
to fluid transition temperature of the lipids. It lead to the formation of
relatively monodisperse vesicles, of which most remained tethered to the
supported bilayer. We interpret these observations in terms of a sharp decrease
of the bending rigidity modulus in the transition region, combined
with a weak initial adhesion energy. On the basis of scaling arguments, we show
that our experimental findings are consistent with this hypothesis.Comment: 11 pages, 3 figure
Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design
International audienceAdhesion in the biological realm is mediated by specific lock-and-key interactions between ligand-receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand-receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering
Compression modulus of macroscopic fiber bundles
We study dense, disordered stacks of elastic macroscopic fibers. These stacks
often exhibit non-linear elasticity, due to the coupling between the applied
stress and the internal distribution of fiber contacts. We propose a
theoretical model for the compression modulus of such systems, and illustrate
our method by studying the conical shapes frequently observed at the
extremities of ropes and other fiber structures. studying the conical shapes
frequently observed at theextremities of ropes and other fiber structures
Neutron reflection study on soluble and insoluble poly[2-(2 '-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene) films
Neutron reflection (NR) has been utilized to study the physical structure of the light-emitting polymer poly[2-(2'-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene) (MEHPPV). Films of soluble MEHPPV (S-MEHPPV) and insoluble MEHPPV (I-MEHPPV) prepared via a chloro precursor polymer were investigated. For S-MEHPPV spin-coated films were found to contain two layers, one of low-density and thickness of approximate to1360 Angstrom with the second layer being thinner, approximate to240 Angstrom, but denser. The thicker layer only covered about 30% of the substrate surface. In contrast, I-MEHPPV formed uniform films across the substrate. We found that during the thermal conversion of the chloro precursor polymer the film thickness was maintained and it was only on cooling that the films contracted. Importantly, the thermal expansion and contraction of I-MEHPPV was reversible. NR showed that thermal annealing of I-MEHPPV had little affect on the films physical structure while for S-MEHPPV only the thinner layer was changed and became more dense. Photoluminescence spectra of S-MEHPPV before and after annealing showed that the densification observed in the neutron reflection measurements was mirrored in the emission properties of the polymer film. (C) 2002 American Institute of Physics
Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope.
Infectious diseases are becoming a major menace to the state of health worldwide, with difficulties in effective treatment especially of nosocomial infections caused by Gram-negative bacteria being increasingly reported. Inadequate permeation of anti-infectives into or across the Gram-negative bacterial cell envelope, due to its intrinsic barrier function as well as barrier enhancement mediated by resistance mechanisms, can be identified as one of the major reasons for insufficient therapeutic effects. Several in vitro, in silico, and in cellulo models are currently employed to increase the knowledge of anti-infective transport processes into or across the bacterial cell envelope; however, all such models exhibit drawbacks or have limitations with respect to the information they are able to provide. Thus, new approaches which allow for more comprehensive characterization of anti-infective permeation processes (and as such, would be usable as screening methods in early drug discovery and development) are desperately needed. Furthermore, delivery methods or technologies capable of enhancing anti-infective permeation into or across the bacterial cell envelope are required. In this respect, particle-based carrier systems have already been shown to provide the opportunity to overcome compound-related difficulties and allow for targeted delivery. In addition, formulations combining efflux pump inhibitors or antimicrobial peptides with anti-infectives show promise in the restoration of antibiotic activity in resistant bacterial strains. Despite considerable progress in this field however, the design of carriers to specifically enhance transport across the bacterial envelope or to target difficult-to-treat (e.g., intracellular) infections remains an urgently needed area of improvement. What follows is a summary and evaluation of the state of the art of both bacterial permeation models and advanced anti-infective formulation strategies, together with an outlook for future directions in these fields
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