Evaluating Conduction Loss of a Parallel IGBT-MOSFET Combination

A variety of power devices are available to designers, each with specific advantages and limitations. For inverters, typically an IGBT combined with a p-i-n diode is used to obtain high current density. Recent developments in high-voltage MOSFETs support other alternatives. For example, a MOSFET can be paralleled with an IGBT to reduce losses at low currents, while the IGBT carries the load at high currents. The current work evaluates conduction losses in this configuration, showing applicability to generic inverters

Low-Input-Voltage, Low-Power Boost Converter Design Issues

Issues associated with boost converter design and performance are investigated when a low input voltage is used. Low-input-voltage sources include single fuel cells, single solar cells, and thermoelectric devices. The primary context is interfacing single micro fuel cells to portable electronic loads, such as mobile phones. Efficiency and circuit startup are the two most difficult issues for a low-cost design. It is shown in theory and experiment that the boost converter has a voltage collapse point. A simple startup technique is proposed that is appropriate for some applications

Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria

Methylmalonic acidemia (MMA) is a propionate pathway disorder caused by dysfunction of the mitochondrial enzyme methylmalonyl-CoA mutase (MMUT). MMUT catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an anaplerotic reaction which feeds into the tricarboxylic acid (TCA) cycle. As part of the pathological mechanisms of MMA, previous studies have suggested there is decreased TCA activity due to a toxic inhibition of TCA cycle enzymes by MMA related metabolites, in addition to reduced anaplerosis. Here, we have utilized mitochondria isolated from livers of a mouse model of MMA (Mut-ko/ki) and their littermate controls (Ki/wt) to examine the amounts and enzyme functions of most of the TCA cycle enzymes. We have performed mRNA quantification, protein semi-quantitation, and enzyme activity quantification for TCA cycle enzymes in these samples. Expression profiling showed increased mRNA levels of fumarate hydratase in the Mut-ko/ki samples, which by contrast had reduced protein levels as detected by immunoblot, while all other mRNA levels were unaltered. Immunoblotting also revealed decreased protein levels of 2-oxoglutarate dehydrogenase and malate dehydrogenase 2. Interesting, the decreased protein amount of 2-oxoglutarate dehydrogenase was reflected in decreased activity for this enzyme while there is a trend towards decreased activity of fumarate hydratase and malate dehydrogenase 2. Citrate synthase, isocitrate dehydrogenase 2/3, succinyl-CoA synthase, and succinate dehydrogenase are not statistically different in terms of quantity of enzyme or activity. Finally, we found decreased activity when examining the function of methylmalonyl-CoA mutase in series with succinate synthase and succinate dehydrogenase in the Mut-ko/ki mice compared to their littermate controls, as expected. This study demonstrates decreased activity of certain TCA cycle enzymes and by corollary decreased TCA cycle function, but it supports decreased protein quantity rather than toxic inhibition as the underlying mechanism of action. SUMMARY: Methylmalonic acidemia (MMA) is an inborn metabolic disorder of propionate catabolism. In this disorder, toxic metabolites are considered to be the major pathogenic mechanism for acute and long-term complications. However, despite optimized therapies aimed at reducing metabolite levels, patients continue to suffer from late complications, including metabolic stroke and renal insufficiency. Since the propionate pathway feeds into the tricarboxylic acid (TCA) cycle, we investigated TCA cycle function in a constitutive MMA mouse model. We demonstrated decreased amounts of the TCA enzymes, Mdh2 and Ogdh as semi-quantified by immunoblot. Enzymatic activity of Ogdh is also decreased in the MMA mouse model compared to controls. Thus, when the enzyme amounts are decreased, we see the enzymatic activity also decreased to a similar extent for Ogdh. Further studies to elucidate the structural and/or functional links between the TCA cycle and propionate pathways might lead to new treatment approaches for MMA patients

Additions to the Aquatic Diptera (Chaoboridae, Chironomidae, Tabanidae, Tipulidae) Fauna of the White River National Wildlife Refuge, Arkansas

The dipteran fauna of Arkansas is generally poorly known. A previous study of the Aquatic macroinvertebrates of the White River National Wildlife Refuge, the largest refuge in Arkansas, reported only 12 diptera taxa out of 219 taxa collected (Chordas et al., 1996). Most of the dipterans from this study were identified only to the family level. The family Chironomidae is a large, diverse group and was predicted to be much more diverse in the refuge than indicated by previous studies. In this study, Chironomidae were targeted, with other aquatic or semiaquatic dipterans also retained, in collections designed to better define the dipteran fauna of the White River National Wildlife Refuge. Adult dipterans were collected from 22 sites within the refuge using sweep-nets, two types of blacklight traps, and lighted fan traps in June of 2001. Specimens from previous studies were retrieved and identified to the lowest possible taxonomic level. A total of 4,917 specimens representing 122 taxa was collected. The 122 taxa were comprised of the following: two chaoborids, 83 chironomids, 15 culicids,nine tabanids, and 13 tipulids. Of these, 46 species are new state records for Arkansas. Nine undescribed species of chironomids were collected, and eight species records represent significant range extensions

The State of the Great Central Valley -- Public Health and Access to Care

Part of a series that provides various quality of life indicators for California's Central Valley. Examines public health and access to health care in the region. Focuses on maternal and child health, senior health, and chronic and communicable diseases

Modern Laboratory-Based Education for Power Electronics and Electric Machines

The study of modern energy conversion draws upon a broad range of knowledge and often requires a fair amount of experience. This suggests that laboratory instruction should be an integral component of a power electronics and electric machines curriculum. However, before a single watt can be processed in a realistic way, the student must understand not only the operation of conversion systems but also more advanced concepts such as control theory, speed and position sensing, switching signal generation, gate drive isolation, circuit layout, and other critical issues. Our approach is to use a blue-box module where these details are pre-built for convenience, but not hidden from the students inside a black box. Recent improvements to our blue-box modules are described in this paper and include a dual-MOSFET control box with independently isolated FET devices, a triple silicon controlled rectifier control box, a discretely built, high quality pulse-width modulation inverter, a small discrete brushless dc drive system, and a high-performance computer-controlled brushless dc dynamometer motor drive system. Complete details, sufficient to allow the reader to duplicate these designs, are publicly available

What is the predictive power of the colobine protein-to-fiber model and its conservation value?

Predicting variation in animal abundance across time and space has proven very difficult; however, a model exists to predict the biomass of small folivorous primates that has considerable correlative support. This model suggests that the protein-to-fiber ratio of leaves in a habitat can predict folivore biomass. Here we present an experimental test of this protein-to-fiber model to assess if the number of infant monkeys per female and group size can be predicted based on the leaf chemistry of a habitat. We expected regenerating forest in Kibale National Park, Uganda to have leaves with higher concentrations of crude protein and lower concentrations of fiber than old-growth forest trees, and consequently, we expected a greater number of infants per female in the folivorous red colobus (Procolobus rufomitratus) with access to this area. As predicted, regenerating forests did have trees with leaves with high concentrations of protein and low concentrations of fiber, but there was no corresponding change in the demographic structure of red colobus groups. We also tested whether energy was a potential determinant of these parameters, but found no evidence for its importance. Our findings support recent studies that are critical of the protein-to-fiber model, which lead us to question the model’s generality, particularly for conservation and management

Apparatus for Converting Direct Current to Alternating Current using Multiple Converters

An inverter for converting an input direct current (DC) waveform from a DC source to an output alternating current (AC) waveform for delivery to an AC grid includes an input converter, an output converter, and an active filter, each of which is electrically coupled to a bus. The bus may be a DC bus or an AC bus. The input converter is configured to convert the input DC waveform to a DC or AC bus waveform. The output converter is configured to convert the bus waveform to the output AC waveform at a grid frequency. The active filter is configured to reduce a double-frequency ripple power of the bus waveform by supplying power to and absorbing power from the power bus

Blue-Box Approach to Power Electronics and Machines Educational Laboratories

Our approach to laboratory education in power electronics and electric machines is presented. The approach centers upon blue-box laboratory components, that aid the student in rapid experiment assembly without disguising important aspects of the hardware. Several example experiments are presented. Schematics and construction techniques for the hardware are publicly available