Performance of electronic dispersion compensator for 10Gb/s multimode fiber links

In high-speed optical links, electronic compensation circuits can be utilized to greatly improve the data transmission performance limited by fiber dispersion. In this paper, we develop a full link model, including multimode fibers, optical/electronics/optical components, clock-and-data recovery and electronic compensation circuits. The performance of various electronic compensation techniques, such as feed-forward equalizer and decision feedback equalizer for optical multimode fiber is investigated and numerically evaluated. Finally, a comparison of the performance of each compensation techniques and a proposal of optimal equalizer circuit implementation, achieving a 10-Gb/s transmission over 1-km standard multimode fiber are presented

Role of Vitamin D in Cardiometabolic Diseases

Vitamin D deficiency is a highly prevalent condition. Low vitamin D levels have long been associated with bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. However, it has become apparent in recent years that adequate vitamin D levels are also important for optimal functioning of many organs and tissues throughout the body, including the cardiovascular system. Evolving data indicate that vitamin D deficiency is associated with an increased risk of cardiovascular disease (CVD). Studies have shown that low vitamin D levels are associated with hypertension, diabetes, metabolic syndrome, left ventricular hypertrophy, and chronic vascular inflammation, all of which are risk factors for CVD. This paper reviews the definition and pathophysiology of vitamin D deficiency, clinical evidence linking vitamin D and CVD risk, diabetes and its complications, and metabolic syndrome

Research on the Application of Fuzzy Bayesian Network in Risk Assessment of Catenary Construction

The research on risk control during the construction stage of catenary is relatively limited. Based on a comprehensive analysis of the risk factors during catenary construction, this study determined the causal relationships between the risk factors and established a risk assessment model for catenary construction that analyzed the risks from a causal logic perspective. During the evaluation process, we identified six exogenous variables and twenty-one endogenous variables for risk factors in the construction of catenary based on a literature review in the field of catenary construction and expert opinions, described the cause-and-effect relationships between variables using structural equations and causal diagrams, and established a multi-level catenary construction risks structural causal model. Based on expert fuzzy evaluation and expert experience, the occurrence probability of exogenous variables and the conditional probability of endogenous variables were determined, respectively. Then, the risk assessment model of catenary construction stage based on fuzzy Bayesian Network was constructed to analyze the risk of catenary construction process. The results showed that the personal quality of the construction personnel and the sense of responsibility of the supervision unit had a great impact on the risk level of catenary construction. The findings can help construction personnel fully consider various weak points in catenary construction, thereby ensuring efficient and high-quality catenary construction

Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway

Background/Aims: Prevention of diabetes requires maintenance of a functional beta-cell mass, the postnatal growth of which depends on beta cell proliferation. Past studies have shown evidence of an effect of an incretin analogue, Exendin-4, in promoting beta cell proliferation, whereas the underlying molecular mechanisms are not completely understood. Methods: Here we studied the effects of Exendin-4 on beta cell proliferation in vitro and in vivo through analysing BrdU-incorporated beta cells. We also analysed the effects of Exendin-4 on beta cell mass in vivo, and on beta cell number in vitro. Then, we applied specific inhibitors of different signalling pathways and analysed their effects on Exendin-4-induced beta cell proliferation. Results: Exendin-4 increased beta cell proliferation in vitro and in vivo, resulting in significant increases in beta cell mass and beta cell number, respectively. Inhibition of PI3K/Akt signalling, but not inhibition of either ERK/MAPK pathway, or JNK pathway, significantly abolished the effects of Exendin-4 in promoting beta cell proliferation. Conclusion: Exendin-4 promotes beta cell proliferation via PI3k/Akt signaling pathway

The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus

Incretin-based therapy is now a prevalent treatment option for patients with type 2 diabetes mellitus (T2DM). It has been associated with considerably good results in the management of hyperglycemia with cardiac or nephron-benefits. For this reason, it is recommended for individuals with cardiovascular diseases in many clinical guidelines. As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight, β cell preservation, and suppressing neurodegeneration. However, recent studies indicate that oral antidiabetic medications interact with endogenous or exogenous GLP-1. Since these drugs are transported to distal intestine portions, there are concerns whether these oral drugs directly stimulate intestinal L cells which release GLP-1, or whether they do so via indirect inhibition of the activity of dipeptidyl peptidase-IV (DPP-IV). In this review, we discuss the metabolic relationships between oral antihyperglycemic drugs from the aspect of gut, microbiota, hormones, β cell function, central nervous system, and other cellular mechanisms