Genetically predicted vitamin K levels and risk of osteoarthritis: Mendelian randomization study

ObjectiveOsteoarthritis (OA) is a progressive disease for which there is no disease modifying therapy. Vitamin K levels and vitamin K antagonism have been associated with risk and progression of OA which may have direct implications for clinical management, but these observational findings are susceptible to confounding. We aimed to estimate the causal association between vitamin K and OA risk using Mendelian randomisation (MR).MethodsWe used data from the largest genome-wide association study (GWAS) of OA to date (up to 826,690 individuals) to estimate the effect of genetically predicted vitamin K level (instrumented using four variants derived from a GWAS of 2,138 individuals) on risk of all OA types, knee, hip, spine, hand OA, and total joint replacement. We employed the inverse-variance weighted method for the primary analysis and, in a series of sensitivity analyses, adjusted for sub-genome wide significant instruments and tested for potential bias from pleiotropy.ResultsWe showed that genetically predicted vitamin K levels were not causally associated with risk of OA overall (OR 0.98 per unit increase in log-transformed vitamin K1; 95%CI 0.96-1.01), knee (OR 0.98; 0.92-1.03), hip (OR 0.97; 0.88-1.07), spine (OR 0.97; 0.90-1.04), hand OA (OR 0.97; 0.91-1.04) or joint replacement (OR 0.96; 0.89-1.04). Results were similar across all sensitivity analyses.ConclusionWe found little evidence of a causal association between genetically predicted vitamin K and OA risk. Larger genetic and interventional studies of vitamin K are required to confirm our findings

Autonomous battery-changing system for UAV’s lifelong flight

Unmanned aerial vehicles (UAVs) lifelong flight is essential to accomplish various tasks, e.g., aerial patrol, aerial rescue, etc. However, traditional UAVs have limited power to sustain their flight and need skilled operators manually control their charging process. Manufacturers and users are eagerly seeking a reliable autonomous battery-changing solution. To address this need, we propose and design an autonomous battery-changing system for UAVs using the theory of inventive problem solving (TRIZ) and user-centered design (UCD) methods. For practical application, we employ UCD to thoroughly analyze user requirements, identify multiple pairs of technical contradictions, and solve these inconsistencies using TRIZ theory. Furthermore, we design an autonomous battery-changing hardware system that meets user requirements and realizes the battery change process after the automatic landing of UAVs. Finally, we conduct experiments to validate our system’s effectiveness. The experimental results show that our battery-changing system can implement the autonomous battery-changing task, and our system has high efficiency and robustness in the real environment

Effects of Flotation Reagents on Flotation Kinetics of Aphanitic (Microcrystalline) Graphite

The flotation method is widely used for the preliminary beneficiation of aphanitic (microcrystalline) graphite. However, there is limited literature regarding the effects of flotation reagents on the flotation kinetics of aphanitic graphite. In this study, six commonly used flotation kinetic models were used to fit the flotation experimental data of aphanitic graphite. The classical first-order model was found to be most suitable for describing flotation kinetics of aphanitic graphite. The modified flotation rate constant (Km) was then applied to evaluate the effects of collector, frother, and inhibitor on aphanitic graphite flotation kinetics. Compared to diesel oil and terpineol oil, kerosene and 2-octanol produced a greater Km. The highest Km was obtained at an inhibitor dosage of 15 mg/L

Effects of Flotation Reagents on Flotation Kinetics of Aphanitic (Microcrystalline) Graphite

The flotation method is widely used for the preliminary beneficiation of aphanitic (microcrystalline) graphite. However, there is limited literature regarding the effects of flotation reagents on the flotation kinetics of aphanitic graphite. In this study, six commonly used flotation kinetic models were used to fit the flotation experimental data of aphanitic graphite. The classical first-order model was found to be most suitable for describing flotation kinetics of aphanitic graphite. The modified flotation rate constant (Km) was then applied to evaluate the effects of collector, frother, and inhibitor on aphanitic graphite flotation kinetics. Compared to diesel oil and terpineol oil, kerosene and 2-octanol produced a greater Km. The highest Km was obtained at an inhibitor dosage of 15 mg/L

Table1_Animal-and mineral-based medicines in Gansu-Ningxia-inner Mongolia region, P.R. China: a cross-cultural ethnobiological assessment.XLSX

Introduction: Traditional animal- and mineral-based medicines are widely used in the Gansu-Ningxia-Inner Mongolia junction zone, a region with diverse ethnic groups and cultures. This study aims to document, conserve, and explore the potential of these medicines for further research and sustainable development of ethnic medicine.Methods: We interviewed 56 informants from different ethnic backgrounds and analyzed their responses quantitatively. Additionally, a comparative analysis with adjacent regions was conducted, providing invaluable contextual insights.Results: The study unveiled a diverse array of traditional medicines in the Gansu-Ningxia-Inner Mongolia junction zone. A total of 47 animal-based medicines were identified, ranging from insects and scorpios to distinctive animal organs. Of notable significance was Moschus, emerging as a pivotal traditional Chinese medicine resource. In parallel, 12 mineral-based medicines were cataloged, procured both locally and from “pharmacies”. Female informants, frequently local herbal practitioners, demonstrated broader knowledge of medicines. The analysis of 13 villages revealed varying perceptions of medicine importance, underscoring the wealth of traditional knowledge. Specific medicines, such as Feng-Mi and Xie-Zi, were widely used and valued in local healthcare practices for their cultural and medicinal benefits.Conclusion: This study provides a comprehensive overview of traditional animal- and mineral-based medicines in the Gansu-Ningxia-Inner Mongolia junction zone. It highlights the need for preserving and applying these practices in a sustainable manner. It also lays a solid foundation for future research on ethnic medicine, which can contribute to the holistic wellbeing of local communities.</p