Planets Across Space and Time (PAST) IV: The Occurrence and Architecture of Kepler Planetary Systems as a Function of Kinematic Age Revealed by the LAMOST-Gaia-Kepler Sample

One of the fundamental questions in astronomy is how planetary systems form and evolve. Measuring the planetary occurrence and architecture as a function of time directly addresses this question. In the fourth paper of the Planets Across Space and Time (PAST) series, we investigate the occurrence and architecture of Kepler planetary systems as a function of kinematic age by using the LAMOST-Gaia-Kepler sample. To isolate the age effect, other stellar properties (e.g., metallicity) have been controlled. We find the following results. (1) The fraction of stars with Kepler-like planets ($F_{\text{Kep}}$) is about 50% for all stars; no significant trend is found between $F_{\text{Kep}}$ and age. (2) The average planet multiplicity ($\bar{N}_p$) exhibits a decreasing trend (~2$\sigma$ significance) with age. It decreases from $\bar{N}_p$~3 for stars younger than 1 Gyr to $\bar{N}_p$~1.8 for stars about 8 Gyr. (3) The number of planets per star ($\eta=F_{\text{Kep}}\times\bar{N}_p$) also shows a decreasing trend (~2-3$\sigma$ significance). It decreases from $\eta$~1.6-1.7 for young stars to $\eta$~1.0 for old stars. (4) The mutual orbital inclination of the planets ($\sigma_{i,k}$) increases from $1.2^{+1.4}_{-0.5}$ to $3.5^{+8.1}_{-2.3}$ as stars aging from 0.5 to 8 Gyr with a best fit of $\log{\sigma_{i,k}}=0.2+0.4\times\log{\frac{\text{Age}}{\text{1Gyr}}}$. Interestingly, the Solar System also fits such a trend. The nearly independence of $F_{\text{Kep}}$~50% on age implies that planet formation is robust and stable across the Galaxy history. The age dependence of $\bar{N}_p$ and $\sigma_{i,k}$ demonstrates planetary architecture is evolving, and planetary systems generally become dynamically hotter with fewer planets as they age.Comment: 27 pages, 20 figures, 4tables, accepted for publication in A

Planets Across Space and Time (PAST). III. Morphology of the Planetary Radius Valley as a Function of Stellar Age and Metallicity in the Galactic Context Revealed by the LAMOST-Gaia-Kepler Sample

The radius valley, a dip in the radius distribution of exoplanets at ~1.9 Earth radii separates compact rocky Super-Earths and Sub-Neptunes with lower density. Various hypotheses have been put forward to explain the radius valley. Characterizing the radius valley morphology and its correlation to stellar properties will provide crucial observation constraints on its origin mechanism and deepen the understanding of planet formation and evolution. In this paper, the third part of the Planets Across the Space and Time (PAST) series, using the LAMOST-Gaia-Kepler catalog, we perform a systematical investigation into how the radius valley morphology varies in the Galactic context, i.e., thin/thick galactic disks, stellar age and metallicity abundance ([Fe/H] and [alpha/Fe]). We find that (1) The valley becomes more prominent with the increase of both age and [Fe/H]. (2) The number ratio of super-Earths to sub-Neptunes monotonically increases with age but decreases with [Fe/H] and [alpha/Fe]. (3) The average radius of planets above the valley (2.1-6 Earth radii) decreases with age but increases with [Fe/H]. (4) In contrast, the average radius of planets below the valley (R < 1.7 Earth radii) is broadly independent on age and metallicity. Our results demonstrate that the valley morphology as well as the whole planetary radius distribution evolves on a long timescale of giga-years, and metallicities (not only Fe but also other metal elements, e.g., Mg, Si, Ca, Ti) play important roles in planet formation and in the long term planetary evolution.Comment: Accepted for pubilication in AJ, 20 Pages, 10 figures, 2 Tables (Appendix: 13 Figures

CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population

Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P = 0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P = 0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population

Nucleocapsid Protein as Early Diagnostic Marker for SARS

Serum samples from 317 patients with patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6–10 days after onset, respectively. The specificity was 99.9%. N protein can be used as an early diagnostic maker for SARS

Effect of Thermoelectric Cooling in Nanoscale Junctions

We propose a thermoelectric cooling device based on an atomic-sized junction. Using first-principles approaches, we investigate the working conditions and the coefficient of performance (COP) of an atomic-scale electronic refrigerator where the effects of phonon's thermal current and local heating are included. It is observed that the functioning of the thermoelectric nano-refrigerator is restricted to a narrow range of driving voltages. Compared with the bulk thermoelectric system with the overwhelmingly irreversible Joule heating, the 4-Al atomic refrigerator has a higher efficiency than a bulk thermoelectric refrigerator with the same $ZT$ due to suppressed local heating via the quasi-ballistic electron transport and small driving voltages. Quantum nature due to the size minimization offered by atomic-level control of properties facilitates electron cooling beyond the expectation of the conventional thermoelectric device theory.Comment: 8 figure

A population of luminous accreting black holes with hidden mergers

Major galaxy mergers are thought to play an important part in fuelling the growth of supermassive black holes. However, observational support for this hypothesis is mixed, with some studies showing a correlation between merging galaxies and luminous quasars and others showing no such association. Recent observations have shown that a black hole is likely to become heavily obscured behind merger-driven gas and dust, even in the early stages of the merger, when the galaxies are well separated (5 to 40 kiloparsecs). Merger simulations further suggest that such obscuration and black-hole accretion peaks in the final merger stage, when the two galactic nuclei are closely separated (less than 3 kiloparsecs). Resolving this final stage requires a combination of high-spatial-resolution infrared imaging and high-sensitivity hard-X-ray observations to detect highly obscured sources. However, large numbers of obscured luminous accreting supermassive black holes have been recently detected nearby (distances below 250 megaparsecs) in X-ray observations. Here we report high-resolution infrared observations of hard-X-ray-selected black holes and the discovery of obscured nuclear mergers, the parent populations of supermassive-black-hole mergers. We find that obscured luminous black holes (bolometric luminosity higher than 2x10^44 ergs per second) show a significant (P<0.001) excess of late-stage nuclear mergers (17.6 per cent) compared to a sample of inactive galaxies with matching stellar masses and star formation rates (1.1 per cent), in agreement with theoretical predictions. Using hydrodynamic simulations, we confirm that the excess of nuclear mergers is indeed strongest for gas-rich major-merger hosts of obscured luminous black holes in this final stage.Comment: To appear in the 8 November 2018 issue of Nature. This is the authors' version of the wor

CMB-S4 Science Book, First Edition

This book lays out the scientific goals to be addressed by the next-generation ground-based cosmic microwave background experiment, CMB-S4, envisioned to consist of dedicated telescopes at the South Pole, the high Chilean Atacama plateau and possibly a northern hemisphere site, all equipped with new superconducting cameras. CMB-S4 will dramatically advance cosmological studies by crossing critical thresholds in the search for the B-mode polarization signature of primordial gravitational waves, in the determination of the number and masses of the neutrinos, in the search for evidence of new light relics, in constraining the nature of dark energy, and in testing general relativity on large scales

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the pathway a therapeutic target. The similarity between the ATP binding site of protein kinases has made development of specific inhibitors difficult. Current JAK2 inhibitors are not selective and produce unwanted side effects. It is thought that increasing selectivity of kinase inhibitors may reduce the side effects seen with current treatment options. Thus, there is a great need for a selective JAK inhibitor. In this study, we identified a JAK2 specific inhibitor. We first identified key pharmacological interactions in the JAK2 binding site by analyzing known JAK2 inhibitors. Then, we performed structure-based virtual screening and filtered compounds based on their pharmacological interactions and identified compound NSC13626 as a potential JAK2 inhibitor. Results of enzymatic assays revealed that against a panel of kinases, compound NSC13626 is a JAK2 inhibitor and has high selectivity toward the JAK2 and JAK3 isozymes. Our cellular assays revealed that compound NSC13626 inhibits colorectal cancer cell (CRC) growth by downregulating phosphorylation of STAT3 and arresting the cell cycle in the S phase. Thus, we believe that compound NSC13626 has potential to be further optimized as a selective JAK2 drug

ATOMS: ALMA Three-millimeter Observations of Massive Star-forming regions – V. Hierarchical fragmentation and gas dynamics in IRDC G034.43+00.24

We present new 3-mm continuum and molecular lines observations from the ATOMS survey towards the massive protostellar clump, MM1, located in the filamentary infrared dark cloud (IRDC), G034.43+00.24 (G34). The lines observed are the tracers of either dense gas (e.g. HCO+/(HCO+)-C-13 J= 1-0) or outflows (e.g. CS J = 2-1). The most complete picture to date of seven cores in MM1 is revealed by dust continuum emission. These cores are found to be gravitationally bound, with virial parameter, alpha(vir) < 2. At least four outflows are identified in MM1 with a total outflowing mass of similar to 45 M-circle dot, and a total energy of 1 x 10(47) erg, typical of outflows from a B0-type star. Evidence of hierarchical fragmentation, where turbulence dominates over thermal pressure, is observed at both the cloud and the clump scales. This could be linked to the scale-dependent, dynamical mass inflow/accretion on clump and core scales. We therefore suggest that the G34 cloud could be undergoing a dynamical mass inflow/accretion process linked to the multiscale fragmentation, which leads to the sequential formation of fragments of the initial cloud, clumps, and ultimately dense cores, the sites of star formation.Peer reviewe