In With The Old, Out With The New: Green Marketing And The Used Merchandise Sector

This study explores the emergence of the used merchandise sector and its implications for green marketing. We demonstrate that although few consumers purchase green products based on environmental concerns, consumers who shop for used merchandise do so with these issues in mind. Examining consumer blogs, we uncover the relationship between the environmental movement and the growth of the used merchandise sector. Green marketing has failed to account for this shift, because it focuses on the consumption of green products rather than consumption reduction facilitated by the used merchandise sector and re-use market. To make a difference, green marketing must change emphasis from consumption to consumption reduction

‘A Most Equitable Drug’: How the Clinical Studies of Convalescent Plasma as a Treatment for SARS-CoV-2 Might Usefully Inform Post-Pandemic Public Sector Approaches to Drug Development

Interventional clinical studies of convalescent plasma to treat COVID-19 were predominantly funded and led by public sector actors, including blood services operators. We aimed to analyze the processes of clinical studies of convalescent plasma to understand alternatives to pharmaceutical industry biopharmaceutical research and development, particularly where public sector actors play a dominant role. We conducted a qualitative, critical case study of purposively sampled prominent and impactful clinical studies of convalescent plasma during 2020-2021. We found that studies were mobilized and scaled at record pace due to well-connected investigators who engaged in widespread sharing of clinical trials resources, regulatory facilitators, and public funding and infrastructure. Clinical studies also served to build public sector and health system capacity and generate clinical trials and blood services infrastructure. Though convalescent plasma represents a failed COVID-19 treatment, key insights from these studies can be used to enhance the likelihood of success of future models of biopharmaceutical production, designed in the service of ensuring equitable access to biopharmaceuticals, should the political will and financing to support such models someday follow

Propuesta para el diseño del sistema de gestión de seguridad y salud en el trabajo para la empresa la casa del café del municipio de Cartago.

Para la empresa La Casa del Café es muy importante la propuesta de trabajo de grado basada en el diseño del Sistema de Gestión de la Seguridad y Salud en el Trabajo teniendo como base los lineamientos de la resolución 0312 de 2019, lo cual permitirá la identificación de sus peligros, su valoración y evaluación, el establecimiento de programas que permitirán su control, para la prevención de accidentes de trabajo o enfermedades laborales. De igual forma el Sistema de Gestión de Seguridad y Salud en el Trabajo, garantiza la mejoran de las condiciones laborales. Por otra parte, se previene que la empresa pueda recibir una sanción de ley, la cual puede ser de tipo económica, por el incumplimiento de los requisitos de las normas de Seguridad y Salud en el Trabajo, o en el evento catastróficos las multas pueden ser por responsabilidad civil e incluso penal.PregradoADMINISTRADOR(A) DE EMPRESA

Experimental analysis of the effect of taxes and subsides on calories purchased in an on-line supermarket

Taxes and subsidies are a public health approach to improving nutrient quality of food purchases. While taxes or subsidies influence purchasing, it is unclear whether they influence total energy or overall diet quality of foods purchased. Using a within subjects design, selected low nutrient dense foods (e.g. sweetened beverages, candy, salty snacks) were taxed, and fruits and vegetables and bottled water were subsidized by 12.5% or 25% in comparison to a usual price condition for 199 female shoppers in an experimental store. Results showed taxes reduced calories purchased of taxed foods (coefficient = -6.61, Cl = -11.94 to -1.28) and subsidies increased calories purchased of subsidized foods (coefficient = 13.74, Cl = 8.51 to 18.97). However, no overall effect was observed on total calories purchased. Both taxes and subsidies were associated with a reduction in calories purchased for grains (taxes: coefficient = -6.58, Cl = -11.91 to -1.24, subsidies: coefficient = -12.86, Cl = -18.08 to -7.63) and subsidies were associated with a reduction in calories purchased for miscellaneous foods (coefficient = -7.40, CI = -12.62 to -2.17) (mostly fats, oils and sugars). Subsidies improved the nutrient quality of foods purchased (coefficient = 0.14, Cl = 0.07 to 0.21). These results suggest that taxes and subsidies can influence energy purchased for products taxed or subsidized, but not total energy purchased. However, the improvement in nutrient quality with subsidies indicates that pricing can shift nutritional quality of foods purchased. Research is needed to evaluate if differential pricing strategies based on nutrient quality are associated with reduction in calories and improvement in nutrient quality of foods purchased

Rapid Response and Restoration for Coral Reef Injuries in Southeast Florida: Guidelines and Recommendations

From the time an injury to coral reef resources is reported, a well-coordinated and implemented plan is critical to the success of response and restoration efforts. There are three major plan components, each of which is equally important: (1) the Initial Response period immediately following notification of the incident; (2) the Response period, during which the Responsible Party (RP) is identified, the Trustees and RP carry out their respective responsibilities, a Primary Restoration plan is developed, authorizations and contractors to conduct restoration activities are sought and obtained, and primary restoration activities are conducted; and (3) the Post-Response period, which is largely a monitoring, compensatory restoration/mitigation, and penalty assessment phase that takes place after primary restoration activities are carried out. The guidelines and recommendations presented in this docuemnt were developed to examine reef injury response processes and to facilitate a rapid response to, and the successful restoration of, southeast Florida reefs. The document was developed as part of a Local Action Strategy (LAS) of the Southeast Florida Coral Reef Initiative (SEFCRI) to develop guidelines and recommendations for a rapid response and restoration process for reef injuries in the SEFCRI region. In February 2006, a two day workshop was held in Fort Lauderdale, Florida, to compile information on existing emergency response processes, identify deficiencies and develop solutions for those processes, and compile information on existing technologies and procedures for triage and the restoration of reef injuries. The first day of the workshop focused on process and policy issues. The second day addressed response, injury and mitigation assessment, restoration and repair, and monitoring. Workshop panelists and attendees included respresentatives from local, state, and federal agencies with proprietary or regulatory authority or jurisdiction over sovereign submerged lands and reef resources located within Florida\u27s waters. Also in attendance were technical and academic experts in the fields of coral reef research, injury assessment, and restoration, as well as marine contractors, private and public attorneys, nongovernmental organizations, and other interested parties. These guidelines and recommendations incorporate information from the combined experience of the workshop attendees, workshop outcomes, published documents, and numerous state and federal regulations, policies, and procedures

Best-Fit Ellipsoids of Atom-Probe Tomographic Data to Study Coalescence of Gamma Prime (L1_2) Precipitates in Ni-Al-Cr

An algorithm is presented to fit precipitates in atom probe tomographic data sets as equivalent ellipsoids. Unlike previous techniques, which measure only the radius of gyration, these ellipsoids retain the moments of inertia and principle axes of the original precipitate, preserving crystallographic orientational information. The algorithm is applied to study interconnected gamma prime precipitates (L1_2) in the Gamma-matrix (FCC) of a Ni-Al-Cr alloy. The precipitates are found to coagulate along -type directions.Comment: Accepted for publication in Scripta Materialia, added information about local magnification effect

Marketing Authorization Applications Made to the European Medicines Agency in 2018-2019:What was the Contribution of Real-World Evidence?

Information derived from routinely collected real-world data has for a long time been used to support regulatory decision making on the safety of drugs and has more recently been used to support marketing authorization submissions to regulators. There is a lack of detailed information on the use and types of this real-world evidence (RWE) as submitted to regulators. We used resources held by the European Medicines Agency (EMA) to describe the characteristics of RWE included in new marketing authorization applications (MAAs) and extensions of indication (EOIs) for already authorized products submitted to the EMA in 2018 and 2019. For MAAs, 63 of 158 products (39.9%) contained RWE with a total of 117 studies. For 31.7% of these products, the RWE submitted was derived from data collected before the planned authorization. The most common data sources were registries (60.3%) followed by hospital data (31.7%). RWE was mainly included to support safety (87.3%) and efficacy (49.2%) with cohort studies being the most frequently used study design (88.9%). For EOIs, 28 of 153 products (18.3%) contained RWE with a total of 36 studies. For 57.1% of these products, studies were conducted prior to the EOIs. RWE sources were mainly registries (35.6%) and hospital data (27.0%). RWE was typically used to support safety (82.1%) and efficacy (53.6%). Cohort studies were the most commonly used study design (87.6%). We conclude that there is widespread use of RWE to support evaluation of MAAs and EOIs submitted to the EMA and identify areas where further research is required

Prescribing Patterns of Codeine and Alternative Medicines in Children in Europe

INTRODUCTION: Concerns over serious respiratory depression in children led to two European Union (EU) referral procedures (in 2013 and 2015) to review the benefit–risk balance of codeine in this population when used for pain relief, cough or cold. Consequently, codeine should no longer be used in children aged < 12 years and restrictions were introduced for treatment in children ≥ 12 years. OBJECTIVE: This multinational collaborative study aimed to assess the effectiveness of these risk minimisation measures by evaluating changes in prescribing of codeine and alternative treatments. METHOD: Children under 12 and 12–18 years old were followed between 2010 and 2017 to analyse quarterly trends in prescribing of codeine and alternative treatments in electronic health records from France, Germany, Norway, Spain and the United Kingdom using interrupted time series analysis. RESULTS: Overall prescribing of codeine in children decreased in all five countries, reaching near zero prevalence in children under 12 years of age. This was accompanied by an increase in use of other opioid analgesics in France (from 0.15 to 0.56 prevalence per 100 person-years immediately after the first referral), Norway (from 0.0006 to 0.0013 at the end of the study), the United Kingdom (from 0.018 to 0.05 at the end of the study), and an increase in non-opioid analgesics in Norway (from 0.045 to 0.075 at the end of the study) after the referral on pain relief indication. The referral on cough/cold indication led to a decrease in use of opioid and non-opioid antitussives in children aged < 12 years in France (from 10 to 7 and 20 to 16, respectively) and had no impact in other countries. Overall prescribing trends for codeine and alternatives were similar across both age groups within each country. CONCLUSION: The decrease in use of codeine shows that healthcare professionals followed the adopted measures and switched prescribing practices for pain management in children aged < 18 years towards opioid or non-opioid analgesics depending on national clinical and reimbursement settings. Whist the magnitude of the first referral on pain differed between countries, the second referral on cough/cold had only a minimal impact on the use of codeine and antitussives. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40264-022-01214-y

Elevated Electron Temperatures in the Auroral E Layer Measured With the Chatanika Radar

An extensive series of spectral measurements has been made in the auroral E region with the Chatanika incoherent scatter radar. Becasue of the small scale length for variations of electron density, temperatures, and ion-neutral collisions we used the operating mode with the best possible range resolution—9 km. About 5% of the time the data exhibited an unusual spectral shape that was most pronounced at 105 and 110 km. Instead of being almost Gaussian with only a small hint of two peaks, the spectra are much wider, with two well-developed peaks. After carefully considering the validity of the measurements and their interpretation, we conclude that the unusual spectra are due to greatly enhanced electron temperatures. At 110 km, the electron temperature may increase from 250 K to 800 K, while the ion temperature remains near 250 K. This enhancement of the electron temperature extends from 99 km to at least 116 km. We show that the temperature increase is too large to be accounted for by auroral particle precipitation, though it coincides in time with ion temperature enhancements at altitudes above 125 km. Because these latter enhancements are believed to be due to joule heating, we deduce that electric fields of 24-40 mV/m are present and that the electrons are moving through the ions and neutrals at speeds of 500-800 m/s. Despite these velocities, we find that joule heating of the electrons also cannot account for the elevated electron temperatures. Several consequences of the elevated electron temperatures are discussed. One is that the rate constants for molecular recombination are reduced. Another is that during periods of significant joule heating, the deduced electron density profile, when fully corrected for temperatures, has a significantly lower peak altitude and greater density than that deduced under the usual assumption of equal electron and ion temperatures. Since conductivities, currents, ionization rates, and differential energy spectra are dependent upon the density profile, care must be taken to account properly for the temperature effects when deriving these quantities

Within-Compound Versus Public Latrine Access and Child Feces Disposal Practices in Low-Income Neighborhoods of Accra, Ghana.

In crowded urban settlements in low-income countries, many households rely on shared sanitation facilities. Shared facilities are not currently considered "improved sanitation" because of concerns about whether hygiene conditions sufficiently protect users from the feces of others. Prevention of fecal exposure at a latrine is only one aspect of sanitary safety. Ensuring consistent use of latrines for feces disposal, especially child feces, is required to reduce fecal contamination in households and communities. Household crowding and shared latrine access are correlated in these settings, rendering latrine use by neighbors sharing communal living areas as critically important for protecting one's own household. This study in Accra, Ghana, found that household access to a within-compound basic latrine was associated with higher latrine use by children of ages 5-12 years and for disposal of feces of children < 5 years, compared with households using public latrines. However, within-compound access was not associated with improved child feces disposal by other caregivers in the compound. Feces was rarely observed in household compounds but was observed more often in compounds with latrines versus compounds relying on public latrines. Escherichia coli and human adenovirus were detected frequently on household surfaces, but concentrations did not differ when compared by latrine access or usage practices. The differences in latrine use for households sharing within-compound versus public latrines in Accra suggest that disaggregated shared sanitation categories may be useful in monitoring global progress in sanitation coverage. However, compound access did not completely ensure that households were protected from feces and microbial contamination