Research Frontier of Accurate Diagnosis and Treatment Guided by Molecular Typing of Hepatocellular Carcinoma

Liver cancer will continue to be a major disease threatening the lives and health of our people in the next few decades. In recent years, with the development of early diagnosis and treatment of liver cancer, precise liver resection, and the development of targeted and immunotherapeutic drugs, the survival rate of liver cancer patients has been improved. Nevertheless, due to the high heterogeneity of liver cancer, patients with liver cancer in the same clinical stage still have great differences in response to treatment and prognosis. New staging and classification indicators are urgently needed to facilitate accurate diagnosis and treatment of liver cancer, so as to further improve the survival rate of patients. The continuous progress and development of multi-omics technology, single-cell technology, tumor molecular visualization technology and medical artificial intelligence, etc., make the molecular classification of liver cancer more and more approaching the true nature of tumor biological characteristics, thus contributing to the accurate diagnosis and treatment of liver cancer

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

The Effect of Sports Game Intervention on Children’s Fundamental Motor Skills: A Systematic Review and Meta-Analysis

The purpose of the present study was to carry out a systematic review and a meta-analysis determining the effects of sports game intervention on fundamental motor skills in children. This paper presented a systematic review from 2001 to 2020, including the databases of Web of Science, EBSCO, Science, PubMed and Springer. (1) Participants comprised 1701 children age 3–12 years; (2) sports game interventions were investigated; (3) only studies using a Test of Gross Motor Skills assessment were included; (4) RCT were chosen as the study design to assess the impact of sports game interventions on children’s motor skills; (5) only culture-based sports game studies in the English and Chinese language were included. Two researchers independently reviewed and assessed the eligibility criteria. Out of the initial 1826 references, 12 studies with a total of 1608 participants were included in the meta-analysis. All interventions were implemented in preschool (kindergarten) or primary school populations, and all studies followed a randomized controlled trial design. The results demonstrated significantly superior development of fundamental motor skills in the intervention groups compared to the control groups (standardized mean difference = 0.30, p < 0.0001). The methodological quality of the included studies ranged from fair to excellent, and no evidence of publication bias was observed. Among them, the 12-week sports game intervention of 35 min each time three to four times a week had a better intervention effect, promoting children’s physical health and fundamental motor skills

Tufting Enteropathy: A Review of Clinical and Histological Presentation, Etiology, Management, and Outcome

Congenital tufting enteropathy (CTE), also named intestinal epithelial dysplasia, is a rare, autosomal recessive enteropathy with persistent and life-threatening intractable diarrhea early in life. Intractable diarrhea is present independent of breast or formula feeding. Most CTE patients require total parenteral nutrition (TPN), and in severe cases, small bowel transplantation is needed. In the last decade, we have seen remarkable progress in certain aspects, such as the pathogenesis and diagnostic methods of the disease. Rapidly developing molecular analysis techniques have improved the diagnostic methods for CTE and reduced invasive and expensive procedures. Mutations in the gene encoding human epithelial cell adhesion molecule (EpCAM) were identified in the typical form of CTE, which usually exhibits isolated refractory diarrhea. Moreover, the syndromic form of CTE features anal and choanal atresias as well as ophthalmologic signs, which are associated with mutations in the gene encoding Serine Peptidase Inhibitor Kunitz Type 2 (SPINT2). This article reviews CTE disease based on its clinical and histological presentation, etiology and pathogenesis, and management and outcome

Circularly polarized UHF RFID tag antenna for wireless sensing of complex permittivity of liquids

This paper presents a compact circularly polarized UHF RFID tag antenna based on complementary split ring resonator (CSRR). Its operating frequency varies with the injected liquid inside the proposed antenna, which is fabricated by 3D printing technology. Based on this feature, the complex relative permittivity of the liquid under test can be extracted wirelessly at a distance from the reader antenna by measuring the read range. The real and imaginary parts of the complex permittivity of the liquid are then extracted from the frequency with the maximum read range and two neighboring frequency points, at which a read range related parameter is 90% of its maximum value. The circular polarization of the proposed antenna is realized by a pair of CSRRs for achieving a relatively large read range and miniaturizing the antenna size. According to the measurement results, the complex relative permittivity of liquids with real part between 1 and 81 can be extracted from a reader with the distance up to 1.97 m.This work was supported in part by the National Key Research and Development Program of China under Grant 2018YFB1802100, in part by the National Natural Science Foundation of China under Grant 61971250 and Grant 62071264, in part by the State Key Laboratory of Millimeter Waves under Grant K202014, in part by the Natural Science Foundation of Zhejiang Province under Grant LY19F010004 and Grant LY21F010004, and in part by the Natural Science Foundation of Ningbo under Grant 2019A610071 and Grant 202003N4109

Alleviation of seeding chlorosis by plant growth regulators in drip-irrigated rice

Drip irrigation can produce high rice yields with significant water savings; therefore, it extends rapidly in water-scarce northern China. However, drip-irrigated rice seedlings often exhibit Fe chlorosis. The objective of this field experiment was thus to determine the ability of plant growth regulators to alleviate chlorosis in drip-irrigated rice seedlings. The study compared three plant growth regulators (1-naphthylacetic acid, NAA; sodium nitrophenolate, CSN; and diethyl aminoethyl hexanoate, DA-6) applied in two ways (seed-soaking and drip-application). The results showed that CSN increased root oxidation activity by 37% in the seed-soaking treatment and by 45% in the soil-application treatment. Seed soaking with NAA, CSN, and DA-6 increased the active Fe content in leaves by 8.8%, 17.5%, and 11.4%, respectively, compared with untreated seedlings. Iron absorption and SPAD values were both greater in the soil-application plots than in the seed-soaking plots. Among the plant growth regulators, CSN resulted in the highest yield (2.2% greater than untreated rice in the seed-soaking treatment and 12.8% greater than untreated rice in the soil-application treatment). In conclusion, CSN significantly improved root Fe uptake at the seedling stage and reduced chlorosis in drip-irrigated rice. Therefore, CSN drip application can be recommended for alleviating rice chlorosis in practical use

High School Adolescents’ Physical Activity and Physical Fitness: A 3 × 2 Achievement Goal Approach

Previous research evidence showed deficient physical activity (PA) and physical fitness (PF) performance levels among high school students. Personal goal orientations motivate their behavior; therefore, it is essential to discover high school students&rsquo; goal orientations in PA and PF. Guided by the latest 3 &times; 2 achievement goal model, we examined the influence of six goal orientations on PA and PF in high school students. A total of 792 high school students in China (54.5% girls; Mage = 16.93 &plusmn; 0.82) completed validated measurements assessing 3 &times; 2 goal orientations for PA and PF. Stepwise multiple regression analyses were used to analyze whether 3 &times; 2 achievement goal orientations significantly influenced the study variables. Other-approach, self-approach, and task-avoidance goals significantly predicted PA, and the 50-meter dash was predicted by other-approach and self-avoidance goals. The self-approach goal was the only significant predictor of the standing long jump. In conclusion, fostering self- and other-approach-oriented environments with developmentally appropriate content in physical education may have implications for enhancing high school students&rsquo; PA and PF

Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis

Background and Aims. Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) have become common chronic liver diseases. Recent evidence has shown the value of transient elastography (TE) in the context of ALD/NAFLD. The aim of this study is to investigate the accuracy of TE for diagnosing steatosis and fibrosis in ALD/NAFLD patients. Methods. We retrieved relevant English studies from the databases of PubMed, Embase, the Web of Science, and the Cochrane Library through March 31st 2019. We included studies regarding the diagnosis or staging of steatosis or fibrosis by using controlled attenuation parameter (CAP) or liver stiffness measurement (LSM) measured by TE in patients with ALD or NAFLD. The reference standard of all included studies was liver biopsy. A random-effects model was applied. Statistical analyses were performed using STATA. Results. A total of 62 articles were included and analyzed in our meta-analysis. In patients with ALD/NAFLD, the pooled results revealed that the sensitivity and specificity of CAP were 0.84, 0.83, and 0.78 and 0.83, 0.71, and 0.62 for steatosis grades ≥S1, ≥S2, and =S3, respectively. The sensitivity and specificity of LSM for identifying fibrosis grades ≥F1, ≥F2, ≥F3, and =F4 were 0.77, 0.77, 0.83, and 0.91 and 0.80, 0.82, 0.84, and 0.86, respectively. Conclusion. In patients with ALD/NAFLD, CAP was feasible for identifying and screening steatosis, and LSM was accurate for diagnosing fibrosis, especially severe fibrosis and cirrhosis

Effects of salinity and nitrogen on cotton growth in arid environment

The influences of different N fertilization rates and soil salinity levels on the growth and nitrogen uptake of cotton was evaluated with a pot experiment under greenhouse conditions. Results showed that cotton growth measured as plant height was significantly affected by the soil salinity and N-salinity interaction, but not by N alone. Cotton was more sensitive to salinity during the emergence and early growth stages than the later developmental stages. At low to moderate soil salinity, the growth inhibition could be alleviated by fertilizer application. Soil salinity was a dominated factor affecting cotton’s above-ground dry mass and root development. Dry mass of seed was reduced by 22%, 52%, and 84% respectively, when the soil salinity level increased from control level of 2.4 dS m−1 to 7.7 dS m−1, 12.5 dS m−1 and to 17.1 dS m−1, respectively. N uptake increased with N fertilization at adequate rates at both low and medium soil salinities but was not influenced by over N fertilization. At higher salinities, N uptake was independent of N rates and mainly influenced by soil salinity. The uptake of K decreased with soil salinity. The concentration of Na, Cl and Ca in plant tissues increased with soil salinity with highest concentrations in the cotton leaf