Research on security factors of mobile payment: taking Alipay, the leader of China's third party payment, as an exemple

Mobile payment is one of the most crucial links in E-commerce. As a representative of third-party payment, Alipay has become the field of payment unicorn enterprises. The purpose of this thesis is to study the security factors affecting mobile payment taking Alipay as the specific research object. Based on the literature review, exploratory factor analysis (EFA) and structural equation model（SEM）analysis were used to conduct empirical research. Data were obtained by random sampling through a questionnaire（N=364） . Research shows that the "Knowledge" at the People aspect, the "System Function" and "Financial Security" at the organization aspect, and the "Transaction Platform" at the Technology aspects have a positive relationship with the safety of Alipay. Based on the above empirical analysis, this thesis puts forward some suggestions on how to improve the safety of AlipayO pagamento móvel é um dos links mais importantes no comércio eletrônico. Como representante de pagamento de terceiros, Alipay tornou-se o campo de empresas de unicórnio de pagamento. O objetivo desta tese é estudar os fatores de segurança que afetam o pagamento móvel tomando Alipay como objeto de pesquisa específico. Com base na revisão da literatura, a análise fatorial exploratória （EFA） e modelo de equações estruturais （SEM ） análise foram utilizados para realizar pesquisas empíricas. Os dados foram obtidos por amostragem aleatória através de um questionário （N = 364） . A pesquisa mostra que o "Conhecimento" no aspecto Pessoas, a "Função do Sistema" e a "Segurança Financeira" no aspecto da organização, e a "Plataforma de Transação" no aspecto Tecnologia têm uma relação positiva com a segurança do Alipay. Com base na análise empírica acima, esta tese apresenta algumas sugestões sobre como melhorar a segurança do Alipay

Significant race and gender differences in anterior cruciate ligament tibial footprint location: a 3D-based analysis

BACKGROUND: The aim of the present study was to identify potential race- or gender-specific differences in anterior cruciate ligament (ACL) tibial footprint location from the tibia anatomical coordinate system (tACS) origin, investigate the distances from the tibial footprint to the anterior root of the lateral meniscus (ARLM) and the medial tibial spine (MTS), determine how reliable the ARLM and MTS can be in locating the ACL tibial footprint, and assess the risk of iatrogenic ARLM injuries caused by using reamers with various diameters (7-10 mm). PATIENTS AND METHODS: Magnetic resonance images of 91 Chinese and 91 Caucasian subjects were used for the reconstruction of three-dimensional (3D) tibial and ACL tibial footprint models. The anatomical coordinate system was applied to reflect the anatomical locations of scanned samples. RESULTS: The average anteroposterior (A/P) tibial footprint location was 17.1 ± 2.3 mm and 20.0 ± 3.4 mm in Chinese and Caucasians, respectively (P < .001). The average mediolateral (M/L) tibial footprint location was 34.2 ± 2.4 mm and 37.4 ± 3.6 mm in Chinese and Caucasians, respectively (P < .001). The average difference between men and women was 2 mm in Chinese and 3.1 mm in Caucasians. The safe zone for tibial tunnel reaming to avoid ARLM injury was 2.2 mm and 1.9 mm away from the central tibial footprint in the Chinese and Caucasians, respectively. The probability of damaging the ARLM by using reamers with various diameters ranged from 0% for Chinese males with a 7 mm reamer to 30% in Caucasian females with a 10 mm reamer. CONCLUSIONS: The significant race- and gender-specific differences in the ACL tibial footprint should be taken in consideration during anatomic ACL reconstruction. The ARLM and MTS are reliable intraoperative landmarks for identifying the tibial ACL footprint. Caucasians and females might be more prone to iatrogenic ARLM injury. LEVEL OF EVIDENCE: III, cohort study. TRIAL REGISTRATION: This study has been approved by the ethical research committee of the General Hospital of Southern Theater Command of PLA under the code: [2019] No.10

Overexpression of Testes-Specific Protease 50 (TSP50) Predicts Poor Prognosis in Patients with Gastric Cancer

Purpose. To investigate the expression of TSP50 protein in human gastric cancers and its correlation with clinical/prognostic significance. Methods. Immunohistochemistry (IHC) analysis of TSP50 was performed on a tissue microarray (TMA) containing 334 primary gastric cancers. Western blot was carried out to confirm the expression of TSP50 in gastric cancers. Results. IHC analysis revealed high expression of TSP50 in 57.2% human gastric cancer samples (191 out of 334). However, it was poorly expressed in all of the 20 adjacent nontumor tissues. This was confirmed by western blot, which showed significantly higher levels of TSP50 expression in gastric cancer tissues than adjacent nontumor tissues. A significant association was found between high levels of TSP50 and clinicopathological characteristics including junior age at surgery (P=0.001), later TNM stage (P=0.000), and present lymph node metastases (P=0.003). The survival of gastric cancer patients with high expression of TSP50 was significantly shorter than that of the patients with low levels of TSP50 (P=0.021). Multivariate Cox regression analysis indicated that TSP50 overexpression was an independent prognostic factor for gastric cancer patients (P=0.017). Conclusions. Our data demonstrate that elevated TSP50 protein expression could be a potential predictor of poor prognosis in gastric cancer patients

ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis

Arsenic is a mitochondrial toxin, and its derivatives, such as arsenic trioxide (ATO), can trigger endoplasmic reticulum (ER) and the associated unfolded protein response (UPR). Here, we show that arsenic induction of the UPR triggers ATF4, which is involved in regulating this ER-mitochondrial crosstalk that is important for the molecular pathogenesis of arsenic toxicity. Employing ATF4+/+ and ATF4−/− MEFs, we show that ATO induces UPR and impairs mitochondrial integrity in ATF4+/+ MEF cells which is largely ablated upon loss of ATF4. Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the enzyme components Rac-1/P47phox/P67phox, which generates ROS/superoxides. Furthermore, ATF4 is required for triggering Ca++/calpain/caspase-12-mediated apoptosis following ATO treatment. The IP3R inhibitor attenuates Ca++/calpain-dependent apoptosis, as well as reduces m-ROS and MMP disruption, suggesting that ER-mitochondria crosstalk involves IP3R-regulated Ca++ signaling. Blockade of m-Ca++ entry by inhibiting m-VDAC reduces ATO-mediated UPR in ATF4+/+ cells. Additionally, ATO treatment leads to p53-regulated mitochondrial apoptosis, where p53 phosphorylation plays a key role. Together, these findings indicate that ATO-mediated apoptosis is regulated by both ER and mitochondria events that are facilitated by ATF4 and the UPR. Thus, we describe novel mechanisms by which ATO orchestrates cytotoxic responses involving interplay of ER and mitochondria.

Lie Symmetry Analysis and Exact Solutions of Generalized Fractional Zakharov-Kuznetsov Equations

This paper considers the Lie symmetry analysis of a class of fractional Zakharov-Kuznetsov equations. We systematically show the procedure to obtain the Lie point symmetries for the equation. Accordingly, we study the vector fields of this equation. Meantime, the symmetry reductions of this equation are performed. Finally, by employing the obtained symmetry properties, we can get some new exact solutions to this fractional Zakharov-Kuznetsov equation

miR-125a-5p Regulates Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells under Oxidative Stress

Adipose-derived mesenchymal stem cells (ADSCs) are a well-recognized multilineage stem cell with vital clinical feasibility for tissue regeneration. Extensive evidence indicates that oxidative stress and microRNAs (miRNAs/miRs) play an important role in the osteoinduction of adipose-derived mesenchymal stem cells. In this study, we investigated the mechanism of miR-125a-5p in regulating the osteogenesis of human adipose-derived mesenchymal stem cells (hADSCs) under oxidative stress. The expression of miR-125a-5p lessened gradually during the osteogenic differentiation of hADSCs. Relative to the negative group, the expression levels of runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin (OCN), and osterix in the miR-125a-5p group were marked lower than those in the miR-125a-5p inhibitor group. The levels of p16, p21, p53, miR-125a-5p, and ROS during osteoinduction of hADSCs were assessed in vitro under oxidative stress and were observed to be upregulated. Further experiments showed that oxidative stress and miR-125a-5p together suppressed the expression of VEGF during osteogenic differentiation of hADSCs and that the inhibition of miR-125a-5p reversed the effect of oxidative stress. In short, our study indicated that miR-125a-5p is induced under oxidative stress and inhibits the expression of VEGF, leading to the reduction of osteogenic differentiation of hADSCs. Our outcomes showed that miR-125a-5p could be a potential clinical target for bone repairing

A Novel Approach for Cable Tension Monitoring Based on Mode Shape Identification

Estimation and monitoring of cable tension is of great significance in the structural assessment of cable-supported bridges. For short cables, the traditional cable tension identification method via frequency measurement has large errors due to the influence of complex boundaries, which affect the accuracy of estimation. A new cable tension estimation method based on mode shape identification with a multiple sensor arrangement on the cable can take the influence of boundary conditions into account and its accuracy has been verified. However, it requires more sensors compared to the traditional frequency-based method, which will significantly increase the cost of long-term monitoring in practice. Therefore, a novel approach for cable tension monitoring considering both cost and accuracy is further proposed in this study. The approach adopts multiple sensors to measure the influence of boundary conditions. Then, only a single sensor is required for long-term monitoring of the cable. In this paper, an analytical model of the cable is firstly established. The influence of boundary conditions is calculated, which ensures the accuracy of mode shape identification. Furthermore, a field experiment is carried out to verify the effectiveness of the new approach. The results have demonstrated the effectiveness and accurateness of the proposed method in long-term short cable tension monitoring

Buckling and stability analysis of a piezoelectric viscoelastic nanobeam subjected to van der Waals forces

A study on the buckling and dynamic stability of a piezoelectric viscoelastic nanobeam subjected to van der Waals forces is performed in this research. The static and dynamic governing equations of the nanobeam are established with Galerkin method and under Euler-Bernoulli hypothesis. The buckling, post-buckling and nonlinear dynamic stability character of the nanobeam is presented. The quasi-elastic method, Leibnitz's rule, Runge-Kutta method and the incremental harmonic balanced method are employed for obtaining the buckling voltage, post-buckling characteristics and the boundaries of the principal instability region of the dynamic system. Effects of the electrostatic load, van der Waals force, creep quantity, inner damping, geometric nonlinearity and other factors on the post-buckling and the principal region of instability are investigated. ? 2013 Elsevier B.V