Source-reservoir rock assemblages and hydrocarbon accumulation models in the Middle-Lower Jurassic of eastern Sichuan Basin, China

The eastern Sichuan Basin in China holds vast potential for oil and gas exploration in the Lower-Middle Jurassic strata. However, the geological characteristics and hydrocarbon accumulation patterns of this region remain largely unclear. During the deposition period of the Lower-Middle Jurassic strata, the eastern Sichuan is characterized by the formation of multiple sets of source, reservoir, and caprock assemblages through depositing lake-delta-fluvial deposits, which have great exploration potential. The Jurassic source rocks in eastern Sichuan are mainly developed in the Dongyuemiao Member, Da’anzhai Member, and Liangshan Formation. These source rocks have a total organic carbon (TOC) content greater than 1 and a varying range of organic matter maturity, with a Ro value of 0.8–2.0. The kerogen in these source rocks is primarily type II, with a smaller proportion being type III. A range of reservoir rocks can be found in the Jurassic strata of eastern Sichuan, with sandstone reservoirs being predominantly found in the Liangshan Formation, Shaximiao Formation, and Zhenzhuchong Member. Shale reservoirs are mostly present in the Dongyuemiao, Da’anzhai, Liangshan, and Maanshan Members, and there is a limited distribution of limestone reservoirs in the Da’anzhai Member and Dongyuemiao Formation. The arrangement of source rocks and reservoir rocks in eastern Sichuan has led to the formation of three types of reservoir-forming combinations, including lower generation and upper storage, self-generation and self-storage, and composite. Sandstone reservoirs are typically of lower generation and upper storage, shale reservoirs are primarily of self-generation and self-storage, and limestone reservoirs are mostly composite. The exploration of Jurassic oil and gas in eastern Sichuan should prioritize “layer and area selections.” The Da’anzhai, Dongyuemiao, and Liangshan shale reservoirs should be the primary exploration targets, with the semi-deep lake deposits in the syncline area being the most favorable. The degree of fracture development in the exploration area also has a significant impact on the shale oil and gas content. The Liangshan Formation and Shaximiao Formation sandstone reservoirs can serve as secondary exploration targets, with anticline areas that have better sealing conditions being more favorable. Limestone reservoirs have limited distribution, and exploration areas with high and steep fractures are relatively more advantageous

EMSL Pore Scale Modeling Challenge/Workshop

Report covers the background for the workshop, objectives, important research directions, necessary capabilities and overall recommendations

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Protocol for lentivirus-mediated delivery of genes to study neurogenesis and cognitive function in adult rodents

Summary: Adult neurogenesis leads to the generation of functional neurons from neural stem cells, whereas impairment of adult hippocampal neurogenesis contributes to the pathophysiology of cognitive symptoms in neurodegenerative and neuropsychiatric diseases. Here, we present a protocol for a direct hippocampal injection of lentivirus-delivered gene in adult rodents to study the specific molecular mechanism underlying adult neurogenesis, including lentivirus packaging and stereotaxic injection, EdU and BrdU injections, tissue immunostaining and imaging analysis, and cognitive testing.For complete details on the use and execution of this protocol, please refer to Li et al. (2023).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics

Application of Computer Graphic Technology in Animated Scene

Animated scene design directedly refers to other styling design besides character design, which plays extremely important role in animated films. Scenes usually vary with plots of story, highlighting atmosphere and style of animation. Therefore, design of animated scene conveys characteristics of both technology and art. This article illustrates the specific application of computer graphic technology in animated scene, featuring the animation, the man on the stage, made by self.</jats:p

Protocol to establish a demyelinated animal model to study hippocampal neurogenesis and cognitive function in adult rodents

Summary: Cognitive dysfunction is a prevalent feature in multiple sclerosis, a chronic inflammatory demyelinating disease, which may be correlated with the impairment of adult hippocampal neurogenesis. Here, we present a detailed protocol for the induction of cuprizone demyelinated mice to assess the cognitive function and explore the precise mechanisms underlying cognitive deficits in demyelinated hippocampus. We describe steps for behavioral tests, 5-Ethynyl-2’-deoxyuridine (EdU) and bromodeoxyuridine (BrdU) administration, retrovirus packaging and stereotactic injection, hippocampal tissue preparation, and immunofluorescence staining.For complete details on the use and execution of this protocol, please refer to Song et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics

Design and Implementation of Virtual Interaction in Tangzha Ancient Town

In recent years, as social and economic progress and living standard of people increases, increasing number of people has financial conditions to relax by travelling, but a host of major cultural tourist attractions are seriously damaged due to natural or human reasons, hence, we are constrained by offline and firsthand travelling experience. The high-speed development of internet technology and continuous improvement of computer software and hardware pave the way for the development and application of virtual reality technology, thus generating a kind of brand-new travelling that is appealed to young man. This article studies the combination of virtual reality technology and cultural tourism resources, taking Tangzha Ancient Town, the first industrial town of Nantong as the pilot.</jats:p