Attention allocation, factor stock adjustment, and high-quality product development

The manufacturing industry is the foundation for building and strengthening a country. Micro-manufacturing enterprises are the basis for the development of manufacturing, and products are the core and life of enterprises. Based on micro data from industrial enterprises, this study conducts a statistical measurement on the indicators of high-quality product development. Taking the Baidu Index as the proxy variable for attention allocation, the influence of attention allocation on high-quality development of products is systematically examined both theoretically and empirically; Additionally, it seeks to ascertain whether factor stock adjustment has a mediating effect. The findings are as follows: 1. Within the full sample, 63.63% of the attention allocation process to promote high-quality development of products is achieved by optimizing the factor stock adjustment channels. 2. Capital stock and labor stock adjustment have a partial mediating effect on the high-quality development of products in capital-intensive industries, while labor stock adjustment has a partial mediating effect on labor-intensive industries. 3. The regional results show that the adjustment of capital and labor stock has a partial mediating effect in the eastern region. This conclusion provides a theoretical basis for realizing the high-quality development of China’s manufacturing industry

Application of infraorbital rim augmentation with pocket fat filling to correct tear trough deformity

BackgroundTear trough deformity is one of the most common complaints in clinical settings. The correction of this groove is challenging in facial rejuvenation. The lower eyelid blepharoplasty varies with different conditions. A novel approach of using orbital fat in the lower eyelid to increase the volume of the infraorbital rim with granule fat injection has been applied in our institution for more than 5 years.ObjectivesThis article aims to describe the detailed steps of our technique and verify its effectiveness by a cadaveric head dissection after surgical simulation.MethodsIn this study, a total of 172 patients with tear trough deformity underwent lower eyelid orbital rim augmentation with fat filling in the sub-periosteum pocket. According to Barton's grades, 152 patients underwent lower eyelid orbital rim augmentation with orbital fat filling, 12 patients had it combined with autologous granule fat from other body parts, and 8 patients received only transconjunctival fat removal to correct tear trough.ResultsThe modified Goldberg score system was used to compare preoperative and postoperative photographs. Patients were satisfied with the cosmetic results. Excessive protruding fat was released, and the tear trough groove was flattened by using autologous orbital fat transplantation. The lower eyelid sulcus deformities were well-corrected. To further illustrate the anatomical structure of the lower eyelid area and injection layers, six cadaveric heads were used for surgical simulation and demonstrated the effectiveness of our technique.ConclusionsThis study indicated that the infraorbital rim could be increased by transplanting orbital fat to the pocket, which was dissected under the periosteum, and the procedure has been verified as reliable and effective.Evidence-based medicine (EBM) levelLevel II

Adjusting the dose of traditional drugs combined with immunotherapy: reshaping the immune microenvironment in lung cancer

Immunotherapy is currently the most promising clinical treatment for lung cancer, not only revolutionizing second-line therapy but now also approved for first-line treatment. However, its clinical efficiency is not high and not all patients benefit from it. Thus, finding the best combination strategy to expand anti-PD-1/PD-L1-based immunotherapy is now a hot research topic. The conventional use of chemotherapeutic drugs and targeted drugs inevitably leads to resistance, toxic side effects and other problems. Recent research, however, suggests that by adjusting the dosage of drugs and blocking the activation of mutational mechanisms that depend on acquired resistance, it is possible to reduce toxic side effects, activate immune cells, and reshape the immune microenvironment of lung cancer. Here, we discuss the effects of different chemotherapeutic drugs and targeted drugs on the immune microenvironment. We explore the effects of adjusting the dosing sequence and timing, and the mechanisms of such responses, and show how the effectiveness and reliability of combined immunotherapy provide improved treatment outcomes

Magnetic γ-Fe2O3-Loaded Attapulgite Sorbent for Hg0 Removal in Coal-Fired Flue Gas

A magnetically recoverable composite mercury removal sorbent was produced by introducing magnetic γ-Fe2O3 into attapulgite (ATT) (xFe1ATT) via the co-precipitation method and used to remove Hg0 in the simulated coal-fired power plant flue gas. The as-prepared 0.5Fe1ATT sorbent was characterized by X-ray diffraction, Brunauer–Emmett–Teller, transmission electron microscopy, vibrating sample magnetometer, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analyses. The results showed that the Hg0 removal performance of the composite of γ-Fe2O3 and ATT was significantly promoted in comparison to pure γ-Fe2O3 and ATT individually. A relatively high magnetization value and good Hg0 removal performance were obtained by the sample of 0.5Fe1ATT. O2 could enhance Hg0 removal activity via the Mars–Maessen mechanism. NO displayed a significant promotion effect on Hg0 removal as a result of the formation of active species, such as NO2 and NO+. SO2 inhibited the removal of Hg0 as a result of its competition adsorption against Hg0 for the active sites and the sulfation of the sorbent. However, the introduction of NO could obviously alleviate the adverse effect of SO2 on the Hg0 removal capability. H2O showed a prohibitive effect on Hg0 removal as a result of its competition with Hg0 for the active sites. The findings of this study are of fundamental importance to the development of efficient and economic magnetic mercury sorbents for Hg0 removal from coal-fired boiler flue gases

Dynamic experimental investigation on the volatilization behavior of lead and cadmium in the simulated Municipal Solid Waste (MSW) influenced by sulfur compounds during incineration

In China, coal, often with a high level of sulfur, is always mixed with municipal solid waste (MSW) in waste incineration plants due to the low heating value and high moisture content of MSW. The influence of sulfur compounds on the volatilization of heavy metals in MSW is of great concern for China’s waste incineration plants. In this study, the continuous dynamic volatilization process of Pb and Cd is investigated by adding different forms of sulfur compounds, elemental sulfur (S), and sodium sulfate (Na2SO4), to the simulated MSW in a laboratory incinerator, at both 1 and 3 wt %, respectively. The experimental results show that the added S begins to affect the volatilization of Pb and Cd at about 700 °C; adding S can lead up to 49.6% reduction in the volatilization of Pb, as the produced sulfur dioxide is promoting the formation of a condensed sulfate phase, and part of Pb is fixed in the form of PbS in the bottom ash. But for Cd, adding S causes up to 15.9% increase in its volatilization as S seizes part of O2 in the air, which is conducive to forming the reducing atmosphere. In the reducing atmosphere, CdO can be easily reduced to Cd, which volatilizes more easily than CdO at high temperatures. In fact, in the reducing atmosphere, the volatilization of Cd far outweighs the volatilization of Pb at 700–800 °C. On the other hand, adding Na2SO4 almost has no influence on the volatilization of lead and cadmium below 900 °C

Modification of heat-induced whey protein gels by basic amino acids

Various amino acids have been studied as gelation enhancers. This study investigated the effect of histidine, lysine, and arginine on gelling properties of heat-induced whey protein isolate (WPI) gels at different pHs. Basic amino acids modified WPI gels in a pH- and amino acid-dependent manner. Hardness and gumminess of the WPI gel was improved by arginine at pH 7.59 while springiness was enhanced by histidine at pHs 7.59 and 9.74 and by lysine at pH 7.59 (P < 0.05). At pH 2.0, WPI formed a weak gel. Lysine and arginine facilitated β-lactoglobulin cross-linking at pH 2.0 and reduced protein leach out from the gel (P < 0.05). At pH 5.2, WPI formed a particulate gel with poor water holding capacity (WHC). Lysine improved WHC of the WPI gel at pH 5.2 by changing the structure of the gel network. At pHs away from 5.2, basic amino acid treatments resulted in a more uniform and porous gel matrix and a greater WHC (P < 0.05). In conclusion, different basic amino acids may be applied as WPI gel enhancers depending on the pH and desired attributes of the product

Study on the Behaviors of a Conceptual Passive Containment Cooling System

The containment is an ultimate and important barrier to mitigate the consequences after the release of mass and energy during such scenarios as loss of coolant accident (LOCA) or main steam line break (MSLB). In this investigation, a passive containment cooling system (PCCS) concept is proposed for a large dry concrete containment. The system is composed of series of heat exchangers, long connecting pipes with relatively large diameter, valves, and a water tank, which is located at the top of the system and serves as the final heat sink. The performance of the system is numerically studied in detail under different conditions. In addition, the influences of condensation heat transfer conditions and containment environment temperature conditions are also studied on the behaviors of the system. The results reveal that four distinct operating stages could be experienced as follows: startup stage, single phase quasisteady stage, flashing speed-up transient stage, and flashing dominated quasisteady operating stage. Furthermore, the mechanisms of system behaviors are thus analyzed. Moreover, the feasibility of the system is also discussed to meet the design purpose for the containment integrity requirement. Considering the passive feature and the compactness of the system, the proposed PCCS is promising for the advanced integral type reactor

An evaluation of EQ-5D-3L health utility scores using five country-specific tariffs in a rural population aged 45-69 years in Hua county, Henan province, China.

BACKGROUND: This study aims to compare the performance of the recently developed Chinese (city) tariff of the EQ-5D-3L against the UK, US, Japanese and Korean tariffs in a general rural population in China. METHODS: From November 2015 to September 2016, 12,085 permanent residents aged 45-69 from 257 villages randomly selected from Hua County, Henan Province, China, were interviewed using EQ-5D-3L, and a one-on-one questionnaire investigation was used to collect data on factors associated with HRQOL. The health utility scores were calculated using the UK, US, Japanese, Korean and Chinese (city) tariffs. The agreement, known-groups validity and sensitivity of these five tariffs were evaluated. Transition scores for pairs of observed EQ-5D-3L health states were calculated and compared. RESULTS: The Korean tariff yielded the highest mean health utility score (0.963), followed by the Chinese (city) (0.948), US (0.943), UK (0.930) and Japanese (0.921) tariffs, but the differences in the scores of any two tariffs did not exceed the MCID. The Chinese (city) tariff showed higher ICC values (ICCs> 0.89, 95% CI:0.755-0.964) and narrower limits of agreement (0.099-0.167) than the Korean tariff [(ICCs> 0.71, 95% CI:0.451-0.955); (0.146-0.253)]. The Chinese (city) tariff had a higher relative efficiency and effect size statistics in 10 out of 11 variables as compared to the UK, US and Japanese tariffs. The Chinese (city) tariff (0.215) was associated with moderate mean absolute transition scores compared with the UK (0.342), US (0.230), Japanese (0.149) and Korean (0.189) tariffs for 1485 observed pairs of the EQ-5D-3L health states. CONCLUSIONS: Health utility scores derived from the five tariffs differed. The Chinese (city) tariff was the most suitable of these tariffs and was without obvious weakness. We recommend adopting the Chinese (city) tariff when applying EQ-5D-3L to assess quality of life among the elderly in China's agricultural region with socio-economic status similar to Hua County. Results of this study had provided a crucial basis for health surveys, health promotion projects, health intervention trials, and health economic evaluation taking HRQOL as a target in rural areas of China