N′-[(E)-1-(5-Bromo-2-hydroxy­phen­yl)ethyl­idene]benzohydrazide

The C=N double bond in the title compound, C15H13BrN2O2, is trans E configured and the dihedral angle between the aromatic ring planes is 22.3 (1)°. The crystal structure is stabilized by intra­molecular O—H⋯O and inter­molecular N—H⋯O hydrogen bonds

(5-Bromo-2-hydroxy­phen­yl)(phen­yl)methanone

In the title compound, C13H9BrO2, the dihedral angle between the aromatic ring planes is 53.6 (1)°. The crystal structure is stabilized by intra­molecular O—H⋯O and inter­molecular C—H⋯O hydrogen bonding and C—H⋯π inter­actions

N′-[(E)-(5-Bromo-2-hydroxy­phen­yl)(phen­yl)methyl­idene]-4-chloro­benzo­hydrazide

The Schiff base, C20H14BrClN2O2, displays a trans conformation with respect to the C=N double bond. The aromatic rings at either end of the –C(=O)–NH–N=C– fragment are nearly parallel [dihedral angle = 3.4 (5)°]. The hydr­oxy group forms an intra­molecular hydrogen bond to the imino N atom

Information-carrying Hawking radiation and the number of microstate for a black hole

AbstractWe present a necessary and sufficient condition to falsify whether a Hawking radiation spectrum indicates unitary emission process or not from the perspective of information theory. With this condition, we show the precise values of Bekenstein–Hawking entropies for Schwarzschild black holes and Reissner–Nordström black holes can be calculated by counting the microstates of their Hawking radiations. In particular, for the extremal Reissner–Nordström black hole, its number of microstate and the corresponding entropy we obtain are found to be consistent with the string theory results. Our finding helps to refute the dispute about the Bekenstein–Hawking entropy of extremal black holes in the semiclassical limit

(meso-5,7,7,12,14,14-Hexamethyl-1,4,8,11-tetra­azacyclo­tetra­deca-4,11-diene)nickel(II) bis­[O,O′-bis(4-methyl­phen­yl) dithio­phosphate]

In the title compound, [Ni(C16H32N4)](C14H14O2PS2)2 or [Ni(trans[14]dien)][S2P(OC6H4Me-4)2]2, where trans[14]dien is meso-5,7,7,12,14,14-hexa­methyl-1,4,8,11-tetra­azacyclo­tetra­deca-4,11-diene, the NiII ion lies across a centre of inversion and is four-coordinated in a relatively undistorted square-planar arrangement by the four N atoms of the macrocyclic ligand trans[14]dien. The two O,O′-di(4-methyl­phen­yl)dithio­phos­phates act as counter-ions to balance the charge. Important geometric data include Ni—N = 1.9135 (16) and 1.9364 (15) Å

Author Correction: Solution-processed hybrid perovskite photodetectors with high detectivity.

This Article contains an error in Equation 2 in that the denominator is inverted. This has not been fixed in the PDF or HTML versions of the Article but can be seen in the associated Correction

N′-[(E)-(5-Bromo-2-hydroxy­phen­yl)(phen­yl)methyl­ene]benzohydrazide

In the title compound, C20H15BrN2O2, the C=N double bond displays a trans configuration. The crystal structure features an intra­molecular O—H⋯N hydrogen bond

Aqueous extract of Aconitum carmichaelii Debeaux attenuates sepsis-induced acute lung injury via regulation of TLR4/NF-ΚB pathway

Purpose: To investigate the therapeutic effect of aqueous extract of Aconitum carmichaelii Debeaux (AEACD) on sepsis-induced acute lung injury (ALI), as well as explore the underlying mechanism of action. Methods: C57BL/6 mice were treated with AEACD by gavage (4.0 g/kg/day) for 5 days before cecal ligation and puncture (CLP) challenge. After 24 h, the pathological morphology of lung tissue and the biochemical parameters in bronchoalveolar lavage fluid (BALF) were determined by H&E staining and enzyme-linked immunosorbent assay (ELISA). Furthermore, the total protein content and lactate dehydrogenase (LDH) level of BALF, as well as the oxidative biomarkers (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD)) were evaluated in the lung homogenates by ELISA assay. The levels of pro-inflammatory cytokines, TNFα, IL-1β, and IL-6, in lung tissue were measured by qRT-PCR or ELISA. Finally, key proteins in Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway in lung tissue were evaluated by western blot. Results: CLP challenge induced abnormal changes in the histological structures of lung tissue, lung wet-to-dry weight (W/D) ratio, protein content and LDH levels of BALF, which were remarkably reversed by AEACD. In addition, AEACD decreased MDA levels, and increased GSH levels and SOD activity in the lung tissue of CLP–treated mice (p < 0.05). Furthermore, AEACD attenuated the CLP challengeinduced upregulation of TNFα, IL-1β, and IL-6. Finally, AEACD inactivated TLR4/NF-κB pathway by upregulating IκBα and downregulating TLR4 and phosphorylated-p65 levels. Conclusion: AEACD administration protects mice against sepsis-induced ALI through the regulation of oxidative stress and inflammatory responses in lung tissues. The underlying mechanism occurs by inhibiting TLR4/NF-κB signaling pathway. Keywords: Aconitum carmichaelii Debeaux, Acute lung injury, Sepsis, TLR4, NF-κ