5,641 research outputs found
A single-photon transistor using nano-scale surface plasmons
It is well known that light quanta (photons) can interact with each other in
nonlinear media, much like massive particles do, but in practice these
interactions are usually very weak. Here we describe a novel approach to
realize strong nonlinear interactions at the single-photon level. Our method
makes use of recently demonstrated efficient coupling between individual
optical emitters and tightly confined, propagating surface plasmon excitations
on conducting nanowires. We show that this system can act as a nonlinear
two-photon switch for incident photons propagating along the nanowire, which
can be coherently controlled using quantum optical techniques. As a novel
application, we discuss how the interaction can be tailored to create a
single-photon transistor, where the presence or absence of a single incident
photon in a ``gate'' field is sufficient to completely control the propagation
of subsequent ``signal'' photons.Comment: 20 pages, 4 figure
Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems
<p>Abstract</p> <p>Background</p> <p>The ability to encode noxious stimulus intensity is essential for the neural processing of pain perception. It is well accepted that the intensity information is transmitted within both sensory and affective pathways. However, it remains unclear what the encoding patterns are in the thalamocortical brain regions, and whether the dual pain systems share similar responsibility in intensity coding.</p> <p>Results</p> <p>Multichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral sensory pain pathway, namely, the ventral posterior lateral thalamic nuclei and the primary somatosensory cortex, and two in the medial pathway, namely, the medial dorsal thalamic nuclei and the anterior cingulate cortex. Neuron number, firing rate, and ensemble spike count codings were examined in this study. Our results showed that the noxious laser stimulation evoked double-peak responses in all recorded brain regions. Significant correlations were found between the laser intensity and the number of responsive neurons, the firing rates, as well as the mass spike counts (MSCs). MSC coding was generally more efficient than the other two methods. Moreover, the coding capacities of neurons in the two pathways were comparable.</p> <p>Conclusion</p> <p>This study demonstrated the collective contribution of medial and lateral pathway neurons to the noxious intensity coding. Additionally, we provide evidence that ensemble spike count may be the most reliable method for coding pain intensity in the brain.</p
Emotions in context: examining pervasive affective sensing systems, applications, and analyses
Pervasive sensing has opened up new opportunities for measuring our feelings and understanding our behavior by monitoring our affective states while mobile. This review paper surveys pervasive affect sensing by examining and considering three major elements of affective pervasive systems, namely; âsensingâ, âanalysisâ, and âapplicationâ. Sensing investigates the different sensing modalities that are used in existing real-time affective applications, Analysis explores different approaches to emotion recognition and visualization based on different types of collected data, and Application investigates different leading areas of affective applications. For each of the three aspects, the paper includes an extensive survey of the literature and finally outlines some of challenges and future research opportunities of affective sensing in the context of pervasive computing
Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients
BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. METHODS. Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ÎFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ÎFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. RESULTS AND DISCUSSION. Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). CONCLUSION. These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.National Heart, Lung, and Blood Institute (NO1-HR-96140, NO1-HR-96141-001, NO1-HR-96144, NO1-HR-96143; NO1-HR-96145; NO1-HR-96142, R01HL086936-03); The Flight Attendant Medical Research Institute; the Jo-Ann F. LeBuhn Center for Chest Diseas
Electromagnetically Induced Transparency and Slow Light with Optomechanics
Controlling the interaction between localized optical and mechanical
excitations has recently become possible following advances in micro- and
nano-fabrication techniques. To date, most experimental studies of
optomechanics have focused on measurement and control of the mechanical
subsystem through its interaction with optics, and have led to the experimental
demonstration of dynamical back-action cooling and optical rigidity of the
mechanical system. Conversely, the optical response of these systems is also
modified in the presence of mechanical interactions, leading to strong
nonlinear effects such as Electromagnetically Induced Transparency (EIT) and
parametric normal-mode splitting. In atomic systems, seminal experiments and
proposals to slow and stop the propagation of light, and their applicability to
modern optical networks, and future quantum networks, have thrust EIT to the
forefront of experimental study during the last two decades. In a similar
fashion, here we use the optomechanical nonlinearity to control the velocity of
light via engineered photon-phonon interactions. Our results demonstrate EIT
and tunable optical delays in a nanoscale optomechanical crystal device,
fabricated by simply etching holes into a thin film of silicon (Si). At low
temperature (8.7 K), we show an optically-tunable delay of 50 ns with
near-unity optical transparency, and superluminal light with a 1.4 microseconds
signal advance. These results, while indicating significant progress towards an
integrated quantum optomechanical memory, are also relevant to classical signal
processing applications. Measurements at room temperature and in the analogous
regime of Electromagnetically Induced Absorption (EIA) show the utility of
these chip-scale optomechanical systems for optical buffering, amplification,
and filtering of microwave-over-optical signals.Comment: 15 pages, 9 figure
Searches for Long Lived Neutral Particles
An intriguing possibility for TeV scale physics is the existence of neutral
long lived particles (LOLIPs) that subsequently decay into SM states. Such
particles are many cases indistinguishable from missing transverse energy (MET)
at colliders. We propose new methods to search for these particles using
neutrino telescopes. We study their detection prospects, assuming production
either at the LHC or through dark matter (DM) annihilations in the Sun and the
Earth. We find that the sensitivity for LOLIPs produced at the LHC is limited
by luminosity and detection energy thresholds. On the other hand, in the case
of DM annihilation into LOLIPs, the sensitivity of neutrino telescopes is
promising and may extend beyond the reach of upcoming direct detection
experiments. In the context of low scale hidden sectors weakly coupled to the
SM, such indirect searches allow to probe couplings as small as 10^-15.Comment: 22 pages, 6 figure
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