BALANCE SHEET EFFECTS AND THE COUNTRY RISK PREMIUM: AN EMPIRICAL INVESTIGATION

This paper investigates empirically whether there is a negative relationship between a country’s risk premium and the balance sheet effect, as implied by recent theories emphasizing financial imperfections. We find evidence that balance sheet effects, stemming from the increase in the external debt service after an unexpected real depreciation, significantly raise the risk premium. We also show that the increase in the risk premium is not due to the debt service as such. While the result holds for the whole sample, we show that it is mainly driven by those countries with the largest financial imperfections, as argued by imperfect capital market theories. Particularly large real depreciations also seem to be disproportionately important, meaning that the balance sheet effects may be strongest at times of economic crisis, when large devaluations occur.balance sheet effects, country risk premium, sovereign spreads

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity.

Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular protein epitopes are recorded by index flow cytometry and positions in arrayed microwells, and then subject to molecular barcoding for subsequent pooled analysis. Pi-ATAC simultaneously identifies the epigenomic and proteomic heterogeneity in individual cells. Pi-ATAC reveals a casual link between transcription factor abundance and DNA motif access, and deconvolute cell types and states in the tumor microenvironment in vivo. We identify a dominant role for hypoxia, marked by HIF1α protein, in the tumor microvenvironment for shaping the regulome in a subset of epithelial tumor cells

How Bilingual Parents Talk to Children About Number in Mandarin and English

Number-related language input has been shown to influence children’s number word acquisition and mathematical ability. Significant differences exist between how Mandarin Chinese speaking parents and monolingual English-speaking parents use numeric language in speech to children. In particular, Mandarin Chinese speaking parents use cardinal number much more frequently in speech to children than do English speaking parents. However, because previous studies have been conducted cross-nationally, research has been unable to disentangle the influences of language from parental influence. The current study examined numeric language input to preschool children with bilingual Mandarin-English American parents. Results show that when parents speak to their children in Mandarin Chinese, children hear more instances and examples of the cardinal number principle than when parents speak to their children in English. This suggests that differences between how the Mandarin Chinese and English languages are structured leads to disparities in how frequently children hear cardinal number in everyday speech

Ultrafast coherent control of giant oscillating molecular dipoles in the presence of static electric fields

The following article appeared in Journal of Chemical Physic 139.8 (2013): 084306 and may be found at http://scitation.aip.org/content/aip/journal/jcp/139/8/10.1063/1.4818878We propose a scheme to generate electric dipole moments in homonuclear molecular cations by creating, with an ultrashort pump pulse, a quantum superposition of vibrational states on electronic states strongly perturbed by very strong static electric fields. By field-induced molecular stabilization, the dipoles can reach values as large as 50 Debyes and oscillate on a time-scale comparable to that of the slow vibrational motion. We show that both the electric field and the pump pulse parameters can be used to control the amplitude and period of the oscillation, while preventing the molecule from ionizing or dissociatingThis work was supported by the NRF grant funded by the Korean government (2007-0056343 and 2012M3C1A6035358), the Basic Science Research program funded by MEST (2010-0005143), the Advanced Grant of the European Research Council XCHEM 290853, the European grant MC-RG ATTOTREND, the European COST Actions CM0702 (CUSPFEL) and CM1204 (XLIC), the European ITN CORINF, the MICINN Project Nos. CTQ2012-36184, FIS2010-15127, and CSD 2007-00010 (Spain), and the ERA-Chemistry project PIM2010EEC-0075

Attosecond transient absorption spectroscopy of molecular hydrogen

We extend attosecond transient absorption spectroscopy (ATAS) to the study of hydrogen molecules, demonstrating the potential of the technique to resolve-simultaneously and with state resolution-both the electronic and nuclear dynamic

Reconstruction of an excited-state molecular wave packet with attosecond transient absorption spectroscopy

Attosecond science promises to allow new forms of quantum control in which a broadband isolated attosecond pulse excites a molecular wave packet consisting of a coherent superposition of multiple excited electronic states. This electronic excitation triggers nuclear motion on the molecular manifold of potential energy surfaces and can result in permanent rearrangement of the constituent atoms. Here, we demonstrate attosecond transient absorption spectroscopy (ATAS) as a viable probe of the electronic and nuclear dynamics initiated in excited states of a neutral molecule by a broadband vacuum ultraviolet pulse. Owing to the high spectral and temporal resolution of ATAS, we are able to reconstruct the time evolution of a vibrational wave packet within the excited B′Σu1+ electronic state of H2 via the laser-perturbed transient absorption spectrumThis material is based on work supported by the DARPA PULSE program through a grant from AMRDEC under Award No. W31P4Q1310017; the Army Research Office under Awards No. W911NF-11-1-0297, No. WN911NF-14- 1-0383, and No. FA9550-16-1-0013; the Air Force Office of Scientific Research under Awards No. FA9550-15-1-0037 and No. FA9550-16-1-0149; the National Science Foundation under Award No. PHY-1506345, an Advanced Grant of the European Research Council XCHEM 290853; and European Grants MC-ITN CORINF, the European COST Action XLIC CM1204, the MINECO Project No. FIS2013-42002-R; and the ERA-Chemistry Project PIM2010EEC-0075

Campaña de lanzamiento del concentrado de chicha morada “Mamá Sara”

El presente trabajo propone una campaña de lanzamiento para una nueva marca de concentrado de chicha morada 100% natural, sin preservantes, saborizantes, colorantes ni azúcar añadida que se introducirá en el mercado peruano y estará dirigida en un principio a las amas de casa. Se presentan los principales hallazgos de los elementos influyentes del entorno que afectan directa o indirectamente al lanzamiento de la marca. Asimismo, rescata las características del público objetivo con el fin de tener un claro entendimiento del perfil del consumidor al cual se apunta. De los insights encontrados en la investigación, se despliega una propuesta de marca que busca identificarse con el público objetivo y generar una recordación, para luego posicionarse como la verdadera chicha morada 100% natural, elaborada con la receta tradicional. Para ello, se preparó un plan de comunicación integral, que contempla un mix de acciones en medios, para apoyar en el conocimiento y recordación de la marca y en la comunicación de sus principales atributos y beneficios

Anemia among Children Exposed to Polyparasitism in Coastal Kenya

Anemia represents a substantial problem for children living in areas with limited resources and significant parasite burden. We performed a cross-sectional study of 254 Kenyan preschool-and early school-age children in a setting endemic for multiple chronic parasitic infections to explore mechanisms of their anemia. Complete venous blood cell counts revealed a high prevalence of local childhood anemia (79%). Evaluating the potential links between low hemoglobin and socioeconomic factors, nutritional status, hemoglobinopathy, and/or parasite infection, we identified age < 9 years (odds ratio [OR]: 12.0, 95% confidence interval [CI]: 4.4, 33) and the presence of asymptomatic malaria infection (OR: 6.8, 95% CI: 2.1, 22) as the strongest independent correlates of having anemia. A total of 130/155 (84%) of anemic children with iron studies had evidence of iron-deficiency anemia (IDA), 16% had non-IDA; 50/52 of additionally tested anemic children met soluble transferrin-receptor (sTfR) criteria for combined anemia of inflammation (AI) with IDA. Children in the youngest age group had the greatest odds of iron deficiency (OR: 10.0, 95% CI: 3.9, 26). Although older children aged 9-11 years had less anemia, they had more detectable malaria, Schistosoma infection, hookworm, and proportionately more non-IDA. Anemia in this setting appears multifactorial such that chronic inflammation and iron deficiency need to be addressed together as part of integrated management of childhood anemia

Transcript-indexed ATAC-seq for precision immune profiling.

T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding genes with assay for transposase-accessible chromatin with sequencing (ATAC-seq) analysis at the single-cell level to provide information on the TCR specificity and epigenomic state of individual T cells. By using this approach, termed transcript-indexed ATAC-seq (T-ATAC-seq), we identified epigenomic signatures in immortalized leukemic T cells, primary human T cells from healthy volunteers and primary leukemic T cells from patient samples. In peripheral blood CD4+ T cells from healthy individuals, we identified cis and trans regulators of naive and memory T cell states and found substantial heterogeneity in surface-marker-defined T cell populations. In patients with a leukemic form of&nbsp;cutaneous T cell lymphoma, T-ATAC-seq enabled identification of leukemic and nonleukemic regulatory pathways in T cells from the same individual by allowing separation of the signals that arose from the malignant clone from the background T cell noise. Thus, T-ATAC-seq is a new tool that enables analysis of epigenomic landscapes in clonal T cells and should be valuable for studies of T cell malignancy, immunity and immunotherapy