710 research outputs found
Climate change impacts, vulnerability and adaptation: Sustaining rice production in Bangladesh
The current study has indicated the most prioritized interventions to be taken against climate change
in Bangladeshi rice growing areas prone to drought and salinity events. The suggested methodology
managed to evaluate a wide range of agricultural interventions through a transparent and userfriendly
approach. The input of stakeholdersâ views has provided valuable feedback for the
empowerment of the study findings. The presentation of the current policy framework and the
ongoing activities in agriculture offers a broad framework on the challenges and constraints to be
met upon application of the suggested interventions
Logarithmic transformation technique for exact signal recovery in frequency-domain optical-coherence tomography
AN APPEAL FROM A JUDGMENT AND DECREE OF DIVORCE OF THE THIRD JUDICIAL DISTRICT, SALT LAKE COUNTY, UTAH THE HONORABLE JOHN A. ROKICH JUDGE PRESIDING
Expanding the portfolio of tribo-positive materials: aniline formaldehyde condensates for high charge density triboelectric nanogenerators
The rapid uptake of energy harvesting triboelectric nanogenerators (TENGs) for self-powered electronics requires the development of high-performance tribo-materials capable of providing large power outputs. This work reports on the synthesis and use of aniline formaldehyde resin (AFR) for energy-harvesting applications. The facile, acidic-medium reaction between aniline and formaldehyde produces the aniline-formaldehyde condensate, which upon an in-vacuo high temperature curing step provides smooth AFR films with abundant nitrogen and oxygen surface functional groups which can acquire a tribo-positive charge and thus endow AFR with a significantly higher positive tribo-polarity than the existing state-of-art polyamide-6 (PA6). A TENG comprising of optimized thin-layered AFR against a polytetrafluoroethylene (PTFE) film produced a peak-to-peak voltage of up to ~1,000 V, a current density of ~65 mA mâ»ÂČ, a transferred charge density of ~200 ÎŒC mâ»ÂČ and an instantaneous power output (energy pulse) of ~11 W mâ»ÂČ (28.1 ÎŒJ cycleâ»Âč), respectively. The suitability of AFR was further supported through the Kelvin probe force microscopy (KPFM) measurements, which reveal a significantly higher average surface potential value of 1.147 V for AFR as compared to 0.87 V for PA6 and a step-by-step increase of the surface potential with the increase of energy generation cycles. The work not only proposes a novel and scalable mouldable AFR synthesis process but also expands with excellent prospects, the current portfolio of tribo-positive materials for triboelectric energy harvesting applications
Not Available
Not AvailablePhytic acid (PA) is an important antinutritional
component in maize that affects the availability
of major micro-nutrients like di- and multivalent
mineral cations like iron (Fe) and zinc (Zn).
The long-term consumption of maize as a staple food
crop leads to micronutrient malnutrition especially
iron and zinc deficiency in the human population. In
addition, it also acts as a storehouse of a major part of
mineral phosphorous (P), approximately 80% of the
total P stored as phytate P is not available to monogastric
animals like humans and poultry birds, and it gets excreted as such, leading to one of the major
environmental pollution called eutrophication. Of the
various low phytic acid (lpa) mutants, lpa2-2 generated
through mutagenesis reduces PA by 30%. BML 6
and BML 45, the parents of the popular maize hybrid
DHM 121 with high PA were selected to introgress
lpa2-2 through marker-assisted backcross breeding
(MABB). The percent recurrent parental genome
(RPG) in the selected BC2F2
plants ranged from 88.68
to 91.04% and 90.09â91.51% in the genetic background
of BML 6 and BML 45, respectively. Based
on the highest percentage of RPG, best five BC2F2
plants, viz., #3190, #3283, #3230, #3263 and #3292
with RPG 88.68â91.04% in the genetic background of
BML 6 and #3720, #3776, #3717, #3828 and #3832
with RPG 90.09â91.51% in the genetic background
of BML 45 were advanced to BC2F3.
The newly
developed near-isogenic lines (NILs) possessed low
phytate content (2.37 mg/g in BML 6 and 2.40 mg/g
in BML 45) compared to 3.59 mg/g and 3.16 mg/g in
recurrent parents BML 6 and BML 45, respectively
thereby reducing the phytate by an average of 34 and
24 per cent, respectively. These newly developed
progenies were similar to their recurrent parents for
various morphological traits. These inbreds assume
great significance in alleviating Fe and Zn deficiencies
in worldwide.Not Availabl
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin
mRNA accumulation in the Cajal bodies of the diplotene larch microsporocyte
In microsporocytes of the European larch, we demonstrated the presence of several mRNAs in spherical nuclear bodies. In the nuclei of microsporocytes, we observed up to 12 bodies, ranging from 0.5 to 6 Όm in diameter, during the prophase of the first meiotic division. Our previous studies revealed the presence of polyadenylated RNA (poly(A) RNA) in these bodies, but did not confirm the presence of nascent transcripts or splicing factors of the SR family. The lack of these molecules precludes the bodies from being the sites of synthesis and early maturation of primary transcripts (KoĆowerzo et al., Protoplasma 236:13â19, 2009). However, the bodies serve as sites for the accumulation of splicing machinery, including the Sm proteins and small nuclear RNAs. Characteristic ultrastructures and the molecular composition of the nuclear bodies, which contain poly(A) RNA, are indicative of Cajal bodies (CBs). Here, we demonstrated the presence of several housekeeping gene transcriptsâα-tubulin, pectin methylesterase, peroxidase and catalase, ATPase, and inositol-3-phosphate synthaseâin CBs. Additionally, we observed transcripts of the RNA polymerase II subunits RPB2 and RPB10 RNA pol II and the core spliceosome proteins mRNA SmD1, SmD2, and SmE. The co-localization of nascent transcripts and mRNAs indicates that mRNA accumulation/storage, particularly in CBs, occurs in the nucleus of microsporocytes
Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke: Clinical and genomic study of nonsmokers with oral tongue cancer
Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use
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The genetic landscape of high-risk neuroblastoma
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%1. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 cases using a combination of whole exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per megabase (0.48 non-silent), and remarkably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, an additional 7.1% had focal deletions), MYCN (1.7%, a recurrent p.Pro44Leu alteration), and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1, and BARD1. The relative paucity of recurrent somatic mutations in neuroblastoma challenges current therapeutic strategies reliant upon frequently altered oncogenic drivers
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