Assessment of knowledge, attitude and practice of interns towards antibiotic resistance and its prescription in a teaching hospital: a cross sectional study

Background: Aim of the present study is to assess the knowledge, attitude and practices adopted by interns towards the antibacterial resistance and prescription.Methods: This is a cross sectional questionnaire based study conducted among the interns working in a teaching hospital. After obtaining the consent, the interns were asked to answer the preformed structured questionnaire to evaluate their knowledge, attitude and practice towards antibiotic resistance and prescription. Completed questionnaire were collected, compiled and data was analysed using descriptive statistics. Chi-square test was also used at appropriate places to determine the statistical significance.Results: A total of 80 participants completed the questionnaire. The response rate was 100%. Most of the interns had good knowledge of antibiotic resistance. 95% of the interns felt that the antibiotic resistance is an important and serious global health issue. Only 21.2% felt the need of antibiotic to treat common cold symptoms. Majority of the respondents agreed with the need of an antibiotic policy in the hospital to achieve rational antibiotic usage. With regard to having a course on rational use of antibiotics in the curriculum, 63.7% agreed and 31.2% strongly agreed.Conclusions: Our study has generated information about the knowledge, attitude and practice of interns towards antibiotic resistance and prescription which can help planning for an effective curriculum regarding antibiotic resistance and prescription

Evaluation of rice–legume–rice cropping system on grain yield, nutrient uptake, nitrogen fixation, and chemical, physical, and biological properties of soil

To achieve higher yields and better soil quality under rice–legume–rice (RLR) rotation in a rainfed production system, we formulated integrated nutrient management (INM) comprised of Azospirillum (Azo), Rhizobium (Rh), and phosphate-solubilizing bacteria (PSB) with phosphate rock (PR), compost, and muriate of potash (MOP). Performance of bacterial bioinoculants was evaluated by determining grain yield, nitrogenase activity, uptake and balance of N, P, and Zn, changes in water stability and distribution of soil aggregates, soil organic C and pH, fungal/bacterial biomass C ratio, casting activities of earthworms, and bacterial community composition using denaturing gradient gel electrophoresis (DGGE) fingerprinting. The performance comparison was made against the prevailing farmers’ nutrient management practices [N/P2O5/K2O at 40:20:20 kg ha−1 for rice and 20:30:20 kg ha−1 for legume as urea/single super-phosphate/MOP (urea/SSP/MOP)]. Cumulative grain yields of crops increased by 7–16% per RLR rotation and removal of N and P by six crops of 2 years rotation increased significantly (P < 0.05) in bacterial bioinoculants-based INM plots over that in compost alone or urea/SSP/MOP plots. Apparent loss of soil total N and P at 0–15 cm soil depth was minimum and apparent N gain at 15–30 cm depth was maximum in Azo/Rh plus PSB dual INM plots. Zinc uptake by rice crop and diethylenetriaminepentaacetate-extractable Zn content in soil increased significantly (P < 0.05) in bacterial bioinoculants-based INM plots compared to other nutrient management plots. Total organic C content in soil declined at 0–15 cm depth and increased at 15–30 cm depth in all nutrient management plots after a 2-year crop cycle; however, bacterial bioinoculants-based INM plots showed minimum loss and maximum gain of total organic C content in the corresponding soil depths. Water-stable aggregation and distribution of soil aggregates in 53–250- and 250–2,000 μm classes increased significantly (P < 0.05) in bacterial bioinoculants-based INM plots compared to other nutrient management plots. Fungal/bacterial biomass C ratio seems to be a more reliable indicator of C and N dynamics in acidic soils than total microbial biomass C. Compost alone or Azo/Rh plus PSB dual INM plots showed significantly (P < 0.05) higher numbers of earthworms’ casts compared to urea/SSP/MOP alone and bacterial bioinoculants with urea or SSP-applied plots. Hierarchical cluster analysis based on similarity matrix of DGGE profiles revealed changes in bacterial community composition in soils due to differences in nutrient management, and these changes were seen to occur according to the states of C and N dynamics in acidic soil under RLR rotation

Ferromagnetically correlated clusters in semi-metallic Ru2NbAl Heusler alloy

In this work, we report the structural, magnetic and electrical and thermal transport properties of the Heusler-type alloy Ru2NbAl. From the detailed analysis of magnetization data, we infer the presence of superparamagnetically interacting clusters with a Pauli paramagnetic background, while short-range ferromagnetic interaction is developed among the clusters below 5 K. The presence of this ferromagnetic interaction is confirmed through heat capacity measurements. The relatively small value of electronic contribution to specific heat, gamma (~2.7 mJ/mol-K2), as well as the linear nature of temperature dependence of Seebeck coefficient indicate a semi-metallic ground state with a pseudo-gap that is also supported by our electronic structure calculations. The activated nature of resistivity is reflected in the observed negative temperature coefficient and has its origin in the charge carrier localization due to antisite defects, inferred from magnetic measurements as well as structural analysis. Although the absolute value of thermoelectric figure of merit is rather low (ZT = 5.2*10-3) in Ru2NbAl, it is the largest among all the reported non-doped full Heusler alloys.Comment: 25 pages, 14 figure

Acute Sciatic Neuritis following Lumbar Laminectomy

It is commonly accepted that the common cause of acute/chronic pain in the distribution of the lumbosacral nerve roots is the herniation of a lumbar intervertebral disc, unless proven otherwise. The surgical treatment of lumbar disc herniation is successful in radicular pain and prevents or limits neurological damage in the majority of patients. Recurrence of sciatica after a successful disc surgery can be due to many possible etiologies. In the clinical setting we believe that the term sciatica might be associated with inflammation. We report a case of acute sciatic neuritis presented with significant persistent pain shortly after a successful disc surgery. The patient is a 59-year-old female with complaint of newly onset sciatica after complete pain resolution following a successful lumbar laminectomy for acute disc extrusion. In order to manage the patient’s newly onset pain, the patient had multiple pain management visits which provided minimum relief. Persistent sciatica and consistent physical examination findings urged us to perform a pelvic MRI to visualize suspected pathology, which revealed right side sciatic neuritis. She responded to the electrical neuromodulation. Review of the literature on sciatic neuritis shows this is the first case report of sciatic neuritis subsequent to lumbar laminectomy

Study of drug utilization pattern in the department of radiotherapy in a tertiary care teaching hospital

Background: Drug utilization studies are an important tool in evaluating the rationality of therapeutic practice and also it is said to improvise the therapeutic use of drugs. The present study will be undertaken to evaluate the drug utilization pattern in the department of Radiotherapy.Methods: This was a prospective, observational study that was undertaken in the department of Radiotherapy in a tertiary care teaching hospital. The study was conducted for a period of 6 months after obtaining permission from Institutional Ethical Committee. The study was conducted among cancer patients undergoing radiotherapy. The data was collected from the patient case records and was analyzed as per the WHO prescribing indicators.Results: In the present study it was observed that the average number of drugs prescribed per encounter was 7.7. The drugs prescribed by generic name were 41.4%. Percentage of encounters with an antibiotic prescribed was 100. Percentage of encounters with an injection prescribed was 20.5%. Percentage of drugs prescribed from essential drugs list was 35.8%.Conclusions: Drug utilization studies helps in modifying the prescription pattern and helps in making the drug usage more rational

Melting and structure of the vortex solid in strongly anisotropic layered superconductors with random columnar pins

We study the melting transition of the low-temperature vortex solid in strongly anisotropic layered superconductors with a concentration of random columnar pinning centers small enough so that the areal density of the pins is much less than that of the vortex lines. Both the external magnetic field and the columnar pins are assumed to be oriented perpendicular to the layers Our method, involving numerical minimization of a model free energy functional, yields not only the free energy values at the local minima of the functional but also the detailed density distribution of the system at each minimum: this allows us to study in detail the structure of the different phases. We find that at these pin concentrations and low temperatures, the thermodynamically stable state is a topologically ordered Bragg glass. This nearly crystalline state melts into an interstitial liquid (a liquid in which a small fraction of vortex lines remain localized at the pinning centers) in two steps, so that the Bragg glass and the liquid are separated by a narrow phase that we identify from analysis of its density structure as a polycrystalline Bose glass. Both the Bragg glass to Bose glass and the Bose glass to interstitial liquid transitions are first-order. We also find that a local melting temperature defined using a criterion based on the degree of localization of the vortex lines exhibits spatial variations similar to those observed in recent experiments.Comment: 17 page