Transitions in the morphological features, habitat use, and diet of young-of-the-year goosefish (Lophius americanus)

This study was designed to improve our understanding of transitions in the early life history and the distribution, habitat use, and diets for young-of-the-year (YOY) goosefish (Lophius americanus) and, as a result, their role in northeastern U.S. continental shelf ecosystems. Pelagic juveniles (>12 to ca. 50 mm total length [TL]) were distributed over most portions of the continental shelf in the Middle Atlantic Bight, Georges Bank, and into the Gulf of Maine. Most individuals settled by 50−85 mm TL and reached approximately 60−120 mm TL by one year of age. Pelagic YOY fed on chaetognaths, hyperiid amphipods, calanoid copepods, and ostracods, and benthic YOY had a varied diet of fishes and benthic crustaceans. Goosefish are widely scattered on the continental shelf in the Middle Atlantic Bight during their early life history and once settled, are habitat generalists, and thus play a role in many continental shelf habi

Deep Network Pharmacology: Targeting Glutamate Systems as Integrative Treatments for Jump-Starting Neural Networks and Recovery Trajectories

Significant advances in pharmacological treatments for mental illness and addiction will require abandoning old monoaminergic theories of psychiatric disorders and traditionally narrow approaches to how we conduct treatment research. Reframing our efforts with a view on integrative treatments that target core neural network function and plasticity may provide new approaches for lifting patients out of chronic psychiatric symptom sets and addiction. For example, we discuss new treatments that target brain glutamate systems at key transition points within longitudinal courses of care that integrate several treatment modalities. A reconsideration of what our novel and already available medications are intended to achieve and how and when we deliver them for patients with complex illness trajectories could be the key to unlocking new advances in general and addiction psychiatry

Einstein Cluster Alignments Revisited

We have examined whether the major axes of rich galaxy clusters tend to point toward their nearest neighboring cluster. We have used the data of Ulmer, McMillan, and Kowalski, who used position angles based on X-ray morphology. We also studied a subset of this sample with updated positions and distances from the MX Northern Abell Cluster Survey (for rich clusters ($R \geq 1$) with well known redshifts). A Kolmogorov-Smirnov (KS) test showed no significant signal for nonrandom angles on any scale $\leq 100h^{-1}$Mpc. However, refining the null hypothesis with the Wilcoxon rank-sum test, we found a high confidence signal for alignment. Confidence levels increase to a high of 99.997% as only near neighbors which are very close are considered. We conclude there is a strong alignment signal in the data, consistent with gravitational instability acting on Gaussian perturbations.Comment: Minor revisions. To be published in Ap

An analysis of a long-lived MCV observed over the Southern Plains using Potential Vorticity diagnostics.

On the morning of 28 May 1998, a mesoscale convectively-generated vortex (MCV) was observed over the Southern Plains. This MCV was evident in the GOES-8 visual satellite imagery resulting in a spectacular picture. An analysis of this event is offered using many data sources, including products available now via the world-wide-web (WWW), the National Center for Environmental Prediction (NCEP) re-analyses, and Eta model initializations. This MCV developed out of a mesoscale convective system (MCS) that existed during 26 and 27 May over Texas. This MCV was associated with reports of severe weather and heavy precipitation over southern Arkansas. While the MCV is shown to have characteristics similar to other MCV events documented, this event is unique in that it maintained it's character, while propagating further east than other events. A dynamical analysis using potential vorticity diagnostics (PV) shows that the mid-latitude vorticity field strengthened at least partially as a result of diabatic heating. Also, the most severe weather was associated with high values of integrated 500 - 300 hPa PV values over the Southern Plains

Selective Effects of D- and L-Govadine in Preclinical Tests of Positive, Negative, and Cognitive Symptoms of Schizophrenia

There is a critical need to develop novel pharmacotherapeutics capable of addressing the positive, negative, and cognitive symptoms of schizophrenia. Building on recent studies with a racemic mixture of the synthetic tetrahydroprotoberberine, D,L-Govadine, we isolated the D- and L-stereoisomers and employed a battery of behavioral, neurochemical, and electrophysiological procedures to assess their individual therapeutic potential. Rodent models predictive of antipsychotic efficacy and those that model positive symptoms were employed and we found that L-Govadine, but not D-Govadine, improved these measures. Pretreatment with either stereoisomer during CS pre-exposure prevented the disruption of latent inhibition by amphetamine. Moreover, pretreatment with either stereoisomer also improved deficits in social interaction in the neonatal ventral hippocampal lesioned rat. Improved cognitive performance in two different prefrontal cortex-dependent tasks was observed with D-, but not L-Govadine, which strongly suggests that the D-steroisomer may be an effective cognitive enhancer. Alterations in dopamine efflux were also assessed and L-Govadine increased dopamine efflux in both the prefrontal cortex and nucleus accumbens. However, D-Govadine only increased dopamine efflux in the prefrontal cortex and not in the nucleus accumbens. Electrophysiological studies confirmed that L-Govadine is a DA-D2 antagonist, whereas D-Govadine shows no appreciable physiological effects at this receptor. Collectively these data show that L-Govadine performs well on measures predictive of antipsychotic efficacy and rodent models of positive symptoms through antagonism of DA-D2 receptors, whereas D-Govadine improves impairments in compromised memory function in delayed response tasks possibly through selective increases in DA efflux in the frontal cortex

A Climatology of Northwest Missouri Snowfall Events: Long Term Trends and Interannual Variability.

The goal of this study was to develop a 50-year statistical climatology of snowfall occurrences using data from a dense network of cooperative station observations covering northwest and central Missouri, and these records were provided by the Missouri Climate Center. This included a study of the long term trends and interannual variability in snowfall occurrence as related to sea surface temperature variations in the Pacific Ocean basin associated with the El Nino and Southern Oscillation (ENSO) and the North Pacific Oscillation (NPO). These trends and variations were then related to four synoptic-scale flow regimes that produce these snowfalls in the Midwest. The results demonstrate that during the snowfall season (Oct - April) the northwest Missouri region can expect about eight snowfall events which produce three or more inches of accumulation. While no significant long-term trend in overall snowfall occurrence was found, a decrease in the number of extreme events (10 or more inches) was noted. Also, fewer snowfall events were found during El Nino years, while more heavy snowfall events occurred during "neutral" years, and these results could be related to synoptic- scale variability. A closer examination of the results demonstrated that El Nino/La Nina related variability in snowfall occurrence was superimposed on longer-term NPO-related variability.This research was supported by the University Corporation for Atmospheric Research (UCAR) Cooperative program for Operational Meteorological Education and Training (COMET) Outreach Programunder award # 98115921

Evidence of Spatially Extensive Resistance to PCBs in an Anadromous Fish of the Hudson River

Populations of organisms that are chronically exposed to high levels of chemical contaminants may not suffer the same sublethal or lethal effects as naive populations, a phenomenon called resistance. Atlantic tomcod (Microgadus tomcod) from the Hudson River, New York, are exposed to high concentrations of polycyclic aromatic hydrocarbons (PAHs) and bioaccumulate polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs). They have developed resistance to PCBs and PCDDs but not to PAHs. Resistance is largely heritable and manifests at early-life-stage toxic end points and in inducibility of cytochrome P4501A (CYP1A) mRNA expression. Because CYP1A induction is activated by the aryl hydrocarbon receptor (AHR) pathway, as are most toxic responses to these compounds, we sought to determine the geographic extent of resistance to CYP1A mRNA induction by PCBs in the Hudson River tomcod population. Samples of young-of-the-year tomcod were collected from seven locales in the Hudson River, extending from the Battery at river mile 1 (RM 1) to RM 90, and from the Miramichi River, New Brunswick, Canada. Laboratory-reared offspring of tomcod adults from Newark Bay, in the western portion of the Hudson River estuary, were also used in this study. Fish were partially depurated in clean water and intraperitoneally injected with 10 ppm coplanar PCB-77, 10 ppm benzo[a]pyrene (BaP), or corn oil vehicle, and levels of CYP1A mRNA were determined. CYP1A was significantly inducible by treatment with BaP in tomcod from the Miramichi River, from laboratory-spawned offspring of Newark Bay origin, and from all Hudson River sites spanning 90 miles of river. In contrast, only tomcod from the Miramichi River displayed significantly induced CYP1A mRNA expression when treated with PCB-77. Our results suggest that the population of tomcod from throughout the Hudson River estuary has developed resistance to CYP1A inducibility and probably other toxicities mediated by the AHR pathway. Tomcod from the Hudson River may represent the most geographically expansive population of vertebrates with resistance to chemical pollutants that has been characterized

Grassroots Training for Reproducible Science:A Consortium-Based Approach to the Empirical Dissertation

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