Sleeping arrangements and mass distribution of bed nets in six districts in central and northern Mozambique

OBJECTIVE: Universal coverage with insecticide-treated bed nets is a cornerstone of modern malaria control. Mozambique has developed a novel bed net allocation strategy, where the number of bed nets allocated per household is calculated on the basis of household composition and assumptions about who sleeps with whom. We set out to evaluate the performance of the novel allocation strategy. METHODS: 1,994 households were visited during household surveys following two universal coverage bed net distribution campaigns in Sofala and Nampula Provinces in 2010-2013. Each sleeping space was observed for the presence of a bed net, and the sleeping patterns for each household were recorded. The observed coverage and efficiency were compared to a simulated coverage and efficiency had conventional allocation strategies been used. A composite indicator, the product of coverage and efficiency, was calculated. Observed sleeping patterns were compared with the sleeping pattern assumptions. RESULTS: In households reached by the campaign, 93% (95% CI: 93-94%) of sleeping spaces in Sofala and 84% (82-86%) in Nampula were covered by campaign bed nets. The achieved efficiency was high, with 92% (91-93%) of distributed bed nets in Sofala and 93% (91-95%) in Nampula covering a sleeping space. Using the composite indicator, the novel allocation strategy outperformed all conventional strategies in Sofala and was tied for best in Nampula. The sleeping pattern assumptions were completely satisfied in 66% of households in Sofala and 56% of households in Nampula. The most common violation of the sleeping pattern assumptions was that male children 3-10 years of age tended not to share sleeping spaces with female children 3-10 or 10-16 years of age. CONCLUSIONS: The sleeping pattern assumptions underlying the novel bed net allocation strategy are generally valid, and net allocation using these assumptions can achieve high coverage and compare favorably with conventional allocation strategies. This article is protected by copyright. All rights reserved

Pituitary disease in MEN type 1 (MEN1): Data from the France-Belgium MEN1 multicenter study

To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We analyzed the data of a large series of 324 MEN1 patients from a French and Belgian multicenter study. Data on pituitary disease were compared with those from 110 non-MEN1 patients with pituitary adenomas, matched for age, year of diagnosis, and follow-up period. Genetic analysis of the MEN1 gene was performed in 197 of the MEN1 patients. In our MEN1 series, pituitary disease occurred in 136 of 324 (42%), less frequently than hyperparathyroidism (95%, P < 0.001) and endocrine enteropancreatic tumors (54%, P < 0.01). Mean age of onset of pituitary tumors was 38.0 +/- 15.3 yr (range, 12-83 yr). Pituitary disease was associated with hyperparathyroidism in 90%. of cases, with enteropancreatic tumors in 47%, with adrenal tumors in 16%, and with thoracic neuroendocrine tumors in 4%. Pituitary disease was the initial lesion of MEN1 in 17% of all MEN1 patients. MEN1 pituitary adenomas were significantly more frequent in women than in men (50% vs. 31%,P < 0.001). Among the 136 pituitary adenomas, there were 85 prolactinomas and 12 GH-secreting, 6 ACTH-secreting, 13 cosecreting, and 20 nonsecreting tumors. Eighty-five percent of MEN1-related pituitary lesions were macroadenomas (vs. 42% in non-MEN1 patients, P < 0.001), including 32% of invasive cases. Among secreting adenomas, hormonal hypersecretion was normalized, after treatment, in only 42% (vs. 90% in non-MEN1 patients, P < 0.001), with a median follow-up of 11.4 yr. No correlation was found between the type of MEN1 germ-line mutation and the presence or absence of pituitary adenoma. Our study, based on a large group of MEN1 patients, shows that pituitary adenomas occur in 42% of the cases and are characterized by a larger size and a more aggressive presentation than without MEN1

First Results of Mg I (3p <SUP>1</SUP>P<SUB>1</SUB>-4d <SUP>1</SUP>D<SUB>2</SUB>) Line Linear Impact Polarization during the Solar Flare on 2001 June 15

International audienceThe results of the analysis of the first spectropolarimetric observations of the 3p 1P1-4d 1D2 Mg I line at 5528.4 Å made during a solar flare are presented in this paper. The line is found to be polarized with a polarization degree at the line center that reaches up to 3% and a direction of polarization nearly parallel to the local transverse magnetic field. After eliminating scattering, the Zeeman effect, and the intensity gradient as possible origins of the observed polarization, this polarization is interpreted as due either to a low-energy proton beam or to the return current associated with electron beams

Sleeping arrangements and mass distribution of bed nets in six districts in central and northern Mozambique

OBJECTIVE: Universal coverage with insecticide-treated bed nets is a cornerstone of modern malaria control. Mozambique has developed a novel bed net allocation strategy, where the number of bed nets allocated per household is calculated on the basis of household composition and assumptions about who sleeps with whom. We set out to evaluate the performance of the novel allocation strategy. METHODS: 1,994 households were visited during household surveys following two universal coverage bed net distribution campaigns in Sofala and Nampula Provinces in 2010-2013. Each sleeping space was observed for the presence of a bed net, and the sleeping patterns for each household were recorded. The observed coverage and efficiency were compared to a simulated coverage and efficiency had conventional allocation strategies been used. A composite indicator, the product of coverage and efficiency, was calculated. Observed sleeping patterns were compared with the sleeping pattern assumptions. RESULTS: In households reached by the campaign, 93% (95% CI: 93-94%) of sleeping spaces in Sofala and 84% (82-86%) in Nampula were covered by campaign bed nets. The achieved efficiency was high, with 92% (91-93%) of distributed bed nets in Sofala and 93% (91-95%) in Nampula covering a sleeping space. Using the composite indicator, the novel allocation strategy outperformed all conventional strategies in Sofala and was tied for best in Nampula. The sleeping pattern assumptions were completely satisfied in 66% of households in Sofala and 56% of households in Nampula. The most common violation of the sleeping pattern assumptions was that male children 3-10 years of age tended not to share sleeping spaces with female children 3-10 or 10-16 years of age. CONCLUSIONS: The sleeping pattern assumptions underlying the novel bed net allocation strategy are generally valid, and net allocation using these assumptions can achieve high coverage and compare favorably with conventional allocation strategies. This article is protected by copyright. All rights reserved

GRAVL: a new satellite mission concept aiming to detect earthquakes with a magnitude of 6.5 Mw and higher

Data from the US and German Gravity Recovery And Climate Experiment (GRACE) showed indications of pre-, co-, and post-seismic mass redistributions associated with earthquakes down to a magnitude of 8.3 Mw. These demonstrated state-of-the-art capabilities in obtaining high spatial resolution space-based gravimetry, and helped to improve understanding of mantle rheology, potentially even providing a route to developing early warning capabilities for future seismic events. We describe a new mission concept, GRAvity observations by Vertical Laser ranging (GRAVL), which aims to extend the earthquake detection limit down to magnitude 6.5 Mw, significantly increasing the number of observable events. GRAVL directly measures the radial component of the acceleration vector via “high-low” inter-satellite laser ranging, increasing gravity field sensitivity. A constellation of Low-Earth Orbit (LEO) satellites act as test masses, equipped with reflectors and high precision accelerometers to account for non-gravitational forces. Two or more larger satellites are placed above these, in Geostationary or Medium Earth Orbit (GEO / MEO), and measure the distance to the LEO satellites via time-of-flight measurement of a laser pulse. To do this, the GEO/MEO spacecraft are each equipped with a laser, telescope and detector, and additionally require highly accurate timing systems to enable ranging accuracy down to sub-micron precision. To detect co-seismic mass redistribution events of the desired magnitude, we determine a gravity field measurement requirement of order 0.1 µGal at a spatial resolution of approximately 100 km over a 3-day revisit interval. These are challenging requirements, and we will discuss possible approaches to achieving them. The GRAVL mission concept was developed during the FFG/ESA Alpbach Summer School 2019 by a team of science and engineering students, and further refined using the Concurrent Engineering approach during the Post-Alpbach Summer School Event at ESA Academy's Training and Learning Facility at ESEC-Galaxia in Belgium