Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers. We tested this by inoculating the duodenal wall of mice with α-Syn preformed fibrils. Following inoculation, we observed gastrointestinal deficits and physiological changes to the enteric nervous system. Using the AAV-PHP.S capsid to target the lysosomal enzyme glucocerebrosidase for peripheral gene transfer, we found that α-Syn pathology is reduced due to the increased expression of this protein. Lastly, inoculation of α-Syn fibrils in aged mice, but not younger mice, resulted in progression of α-Syn histopathology to the midbrain and subsequent motor defects. Our results characterize peripheral synucleinopathy in prodromal Parkinson’s disease and explore cellular mechanisms for the gut-to-brain progression of α-Syn pathology

Bragg scattering of Cooper pairs in an ultra-cold Fermi gas

We present a theoretical treatment of Bragg scattering of a degenerate Fermi gas in the weakly interacting BCS regime. Our numerical calculations predict correlated scattering of Cooper pairs into a spherical shell in momentum space. The scattered shell of correlated atoms is centered at half the usual Bragg momentum transfer, and can be clearly distinguished from atoms scattered by the usual single-particle Bragg mechanism. We develop an analytic model that explains key features of the correlated-pair Bragg scattering, and determine the dependence of this scattering on the initial pair correlations in the gas.Comment: Manuscript substantially revised. Version 2 contains a more detailed discussion of the collisional interaction used in our theory, and is based on three-dimensional solution

Nonlinear atom-optical delta-kicked harmonic oscillator using a Bose-Einstein condensate

We experimentally investigate the atom-optical delta-kicked harmonic oscillator for the case of nonlinearity due to collisional interactions present in a Bose-Einstein condensate. A Bose condensate of rubidium atoms tightly confined in a static harmonic magnetic trap is exposed to a one-dimensional optical standing-wave potential that is pulsed on periodically. We focus on the quantum anti-resonance case for which the classical periodic behavior is simple and well understood. We show that after a small number of kicks the dynamics is dominated by dephasing of matter wave interference due to the finite width of the condensate's initial momentum distribution. In addition, we demonstrate that the nonlinear mean-field interaction in a typical harmonically confined Bose condensate is not sufficient to give rise to chaotic behavior.Comment: 4 pages, 3 figure

An Atlas of Spectrophotometric Landolt Standard Stars

We present CCD observations of 102 Landolt standard stars obtained with the R-C spectrograph on the CTIO 1.5 m telescope. Using stellar atmosphere models we have extended the flux points to our six spectrophotometric secondary standards, in both the blue and the red, allowing us to produce flux-calibrated spectra that span a wavelength range from 3050 \AA to 1.1 \micron. Mean differences between UBVRI spectrophotometry computed using Bessell's standard passbands and Landolt's published photometry is found to be 1% or less. Observers in both hemispheres will find these spectra useful for flux-calibrating spectra and through the use of accurately constructed instrumental passbands be able to compute accurate corrections to bring instrumental magnitudes to any desired standard photometric system (S-corrections). In addition, by combining empirical and modeled spectra of the Sun, Sirius and Vega, we calculate and compare synthetic photometry to observed photometry taken from the literature for these three stars.Comment: Added referee's comments, minor corrections, replaced Table 1

An ultraviolet excess in the superluminous supernova Gaia16apd reveals a powerful central engine

Since the discovery of superluminous supernovae (SLSNe) in the last decade, it has been known that these events exhibit bluer spectral energy distributions than other supernova subtypes, with significant output in the ultraviolet. However, the event Gaia16apd seems to outshine even the other SLSNe at rest-frame wavelengths below $\sim 3000$ \AA. Yan et al (2016) have recently presented HST UV spectra and attributed the UV flux to low metallicity and hence reduced line blanketing. Here we present UV and optical light curves over a longer baseline in time, revealing a rapid decline at UV wavelengths despite a typical optical evolution. Combining the published UV spectra with our own optical data, we demonstrate that Gaia16apd has a much hotter continuum than virtually any SLSN at maximum light, but it cools rapidly thereafter and is indistinguishable from the others by $\sim 10$-15 days after peak. Comparing the equivalent widths of UV absorption lines with those of other events, we show that the excess UV continuum is a result of a more powerful central power source, rather than a lack of UV absorption relative to other SLSNe or an additional component from interaction with the surrounding medium. These findings strongly support the central-engine hypothesis for hydrogen-poor SLSNe. An explosion ejecting $M_{\rm ej} = 4 (0.2/\kappa)$ M$_\odot$, where $\kappa$ is the opacity in cm$^2$g$^{-1}$, and forming a magnetar with spin period $P=2$ ms, and $B=2\times10^{14}$ G (lower than other SLSNe with comparable rise-times) can consistently explain the light curve evolution and high temperature at peak. The host metallicity, $Z=0.18$ Z$_\odot$, is comparable to other SLSNe.Comment: Updated to match accepted version (ApJL

Time Dilation from Spectral Feature Age Measurements of Type Ia Supernovae

We have developed a quantitative, empirical method for estimating the age of Type Ia supernovae (SNe Ia) from a single spectral epoch. The technique examines the goodness of fit of spectral features as a function of the temporal evolution of a large database of SNe Ia spectral features. When a SN Ia spectrum with good signal-to-noise ratio over the rest frame range 3800 to 6800 A is available, the precision of a spectral feature age (SFA) is (1-sigma) ~ 1.4 days. SFA estimates are made for two spectral epochs of SN 1996bj (z=0.574) to measure the rate of aging at high redshift. In the 10.05 days which elapsed between spectral observations, SN 1996bj aged 3.35 $\pm$ 3.2 days, consistent with the 6.38 days of aging expected in an expanding Universe and inconsistent with no time dilation at the 96.4 % confidence level. The precision to which individual features constrain the supernova age has implications for the source of inhomogeneities among SNe Ia.Comment: 14 pages (LaTex), 7 postscript figures to Appear in the Astronomical Journa

Multi-color Optical and NIR Light Curves of 64 Stripped-Envelope Core-Collapse Supernovae

We present a densely-sampled, homogeneous set of light curves of 64 low redshift (z < 0.05) stripped-envelope supernovae (SN of type IIb, Ib, Ic and Ic-bl). These data were obtained between 2001 and 2009 at the Fred L. Whipple Observatory (FLWO) on Mt. Hopkins in Arizona, with the optical FLWO 1.2-m and the near-infrared PAIRITEL 1.3-m telescopes. Our dataset consists of 4543 optical photometric measurements on 61 SN, including a combination of UBVRI, UBVr'i', and u'BVr'i', and 2142 JHKs near-infrared measurements on 25 SN. This sample constitutes the most extensive multi-color data set of stripped-envelope SN to date. Our photometry is based on template-subtracted images to eliminate any potential host galaxy light contamination. This work presents these photometric data, compares them with data in the literature, and estimates basic statistical quantities: date of maximum, color, and photometric properties. We identify promising color trends that may permit the identification of stripped-envelope SN subtypes from their photometry alone. Many of these SN were observed spectroscopically by the CfA SN group, and the spectra are presented in a companion paper (Modjaz et al. 2014). A thorough exploration that combines the CfA photometry and spectroscopy of stripped-envelope core-collapse SN will be presented in a follow-up paper.Comment: 26 pages, 17 figures, 8 tables. Revised version resubmitted to ApJ Supplements after referee report. Additional online material is available through http://cosmo.nyu.edu/SNYU

Optical Spectra of 73 Stripped-Envelope Core-Collapse Supernovae

We present 645 optical spectra of 73 supernovae (SNe) of Types IIb, Ib, Ic, and broad-lined Ic. All of these types are attributed to the core collapse of massive stars, with varying degrees of intact H and He envelopes before explosion. The SNe in our sample have a mean redshift = 4200 km/s. Most of these spectra were gathered at the Harvard-Smithsonian Center for Astrophysics (CfA) between 2004 and 2009. For 53 SNe, these are the first published spectra. The data coverage range from mere identification (1-3 spectra) for a few SNe to extensive series of observations (10-30 spectra) that trace the spectral evolution for others, with an average of 9 spectra per SN. For 44 SNe of the 73 SNe presented here, we have well-determined dates of maximum light to determine the phase of each spectrum. Our sample constitutes the most extensive spectral library of stripped-envelope SNe to date. We provide very early coverage (as early as 30 days before V-band max) for photospheric spectra, as well as late-time nebular coverage when the innermost regions of the SNe are visible (as late as 2 years after explosion, while for SN1993J, we have data as late as 11.6 years). This data set has homogeneous observations and reductions that allow us to study the spectroscopic diversity of these classes of stripped SNe and to compare these to SNe associated with gamma-ray bursts. We undertake these matters in follow-up papers.Comment: Published by the Astronomical Journal in May 2015. All spectra are publicly available at the CfA SN archive: http://www.cfa.harvard.edu/supernova/SNarchive.html . A companion paper on constructing SNID templates based on these spectra is by Liu & Modjaz (2014) and the resulting SNID templates are available from the NYU website: http://cosmo.nyu.edu/SNYU/spectra

Analytic Inversion of Emission Lines of Arbitrary Optical Depth for the Structure of Supernova Ejecta

We derive a method for inverting emission line profiles formed in supernova ejecta. The derivation assumes spherical symmetry and homologous expansion (i.e., $v(r) \propto r$), is analytic, and even takes account of occultation by a pseudo-photosphere. Previous inversion methods have been developed which are restricted to optically thin lines, but the particular case of homologous expansion permits an analytic result for lines of {\it arbitrary} optical depth. In fact, we show that the quantity that is generically retrieved is the run of line intensity $I_\lambda$ with radius in the ejecta. This result is quite general, and so could be applied to resonance lines, recombination lines, etc. As a specific example, we show how to derive the run of (Sobolev) optical depth $\tau_\lambda$ with radius in the case of a pure resonance scattering emission line.Comment: 6 pages, no figures, to appear in Astrophysical Journal Letters, requires aaspp4.sty to late