12 research outputs found
Predetermination of Performance Parameters of 3-phase Induction Motor using Numerical Technique Tools
The Circle Diagram was used in past for the performance evaluation of 3-phase induction motor under different load conditions. But, now it is not preferred due to availability of programs for detailed analysis. The per-phase equivalent circuit is also not that suitable to estimate the dynamic performance. In this paper, a method is suggested to determine the performance using dq-model. The objective of this paper is to describe modelling in terms of dq variables. The analysis under steady state condition is done using numerical technique tools. The numerical tools such as Gauss-Seidel and Successive Relaxation methods are used and the results are compared with that obtained from the experiment conducted in the laboratory. The comparison of results confirms the validity as well as the accuracy of the proposed methods, as yet another approach to predetermine the performance
Rural Load Management Using Information Technology
The mismatch between the generation and demand for electrical power is increasing at an alarming rate. This is mainly due shortage of conventional resources, use of appropriate technology for alternate energy sources and lack of awareness about energy conservation. Power supply to domestic, commercial and industrial consumers is a difficult task to the utilities controlled by the government. In rural India, irrigation pump sets are the major loads. The technical aptitude, attitude and co operation of the consumers helps a lot in energy management. The strategic power supply is affected if the consumers are not complying with the norms. A strategy is framed to provide power to domestic appliances around the clock and agricultural consumers on time division basis. But the local technicians play a corruptive role to violate this which is leading to overloading/failure of the distribution transformers frequently. Here, an attempt is made to devise a method to overcome the problem of agricultural consumers who are getting power on time division basis. A control unit is installed at each distribution station to automatically monitor and control the power supply to domestic and agricultural consumers as per the pre defined schedule. This paper explains the use of electronics and information technology in rural areas for better management of the power supply and consumption. The unauthorized connection leading to failure of distribution transformers is also taken care
Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein. Medicinal chemistry optimization led to improvements in potency and solubility. Indole amide 3 represents a novel uncompetitive inhibitor with excellent physical and pharmaceutical properties that can be used as a starting point for drug discovery efforts
Power Quality Issues In Indian Power Distribution Utilities And Feasible Solutions
Abstract: One important contributing factor to India's slow pace of development in general and relatively poor industrial growth in particular is the poor quality and reliability of the electrical power. Earlier, the consumers of electrical energy were mere acceptors. Interruptions and other voltage disturbances were part of the deal. But today, electric power is viewed as a product with certain characteristics which can be measured, predicted, guaranteed, improved, etc. which has become an integral part of our life. This paper gives insights on different Power Quality (PQ) problems experienced by the Indian electricity consumers, and the reasons for those problems. This paper proposes feasible solutions to assist in employing or implementing appropriate mitigation techniques with an optimism of an improvement in the field scenario as more and more investments are proposed in Generation, Transmission and Distribution Sectors, and stringent codes and standards are being imposed for those who do not maintain minimum PQ level in the field
A Novel method of Starting Induction Motor - A Comparative Study
Polyphase induction motor, when started from rest with full voltage impressed, the starting current is 5 to 8 or more times the rated current. The large line current drawn by such a motor is objectionable because of the possible sharp drop in voltage of the supply circuit and undesired effects upon other connected loads/devices. Accordingly it is customary to start such motors at reduced voltage by using auto transformers, star delta starters etc. This paper deals with a new approach to start poly phase induction motors without using any primary voltage compensators thereby limiting the inrush of starting current. The rotor of the motor is driven at suitable speed in the specified direction of rotation by using crank driving mechanism. Then te rated voltage is applied to the motor. This is enunciated using a case study on a 3- phase, 5hp, NGEF make motor with oscillographic records obtained from the experimentation and is compared with the various starting techniques. Keywords: Induction motor, starter, inrush current, voltage dip, new approachDOI: http://dx.doi.org/10.11591/ijpeds.v1i1.7
Rural Load Management using Information Technology
The mismatch between the generation and demand for electrical power is increasing at an alarming rate. This is mainly due shortage of conventional resources, use of appropriate technology for alternate energy sources and lack of awareness about energy conservation. Power supply to domestic, commercial and industrial consumers is a difficult task to the utilities controlled by the government. In rural India, irrigation pump sets are the major loads. The technical aptitude, attitude and co operation of the consumers helps a lot in energy management. The strategic power supply is affected if the consumers are not complying with the norms. A strategy is framed to provide power to domestic appliances around the clock and agricultural consumers on time division basis. But the local technicians play a corruptive role to violate this which is leading to overloading/failure of the distribution transformers frequently. Here, an attempt is made to devise a method to overcome the problem of agricultural consumers who are getting power on time division basis. A control unit is installed at each distribution station to automatically monitor and control the power supply to domestic and agricultural consumers as per the pre defined schedule. This paper explains the use of electronics and information technology in rural areas for better management of the power supply and consumption. The unauthorized connection leading to failure of distribution transformers is also taken care
Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells
Gamendazole was recently identified as an orally active antispermatogenic compound with antifertility effects. The cellular mechanism(s) through which these effects occur and the molecular target(s) of gamendazole action are currently unknown. Gamendazole was recently designed as a potent orally active antispermatogenic male contraceptive agent. Here, we report the identification of binding targets and propose a testable mechanism of action for this antispermatogenic agent. Both HSP90AB1 (previously known as HSP90beta [heat shock 90-kDa protein 1, beta]) and EEF1A1 (previously known as eEF1A [eukaryotic translation elongation factor 1 alpha 1]) were identified as binding targets by biotinylated gamendazole (BT-GMZ) affinity purification from testis, Sertoli cells, and ID8 ovarian cancer cells; identification was confirmed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and Western blot analysis. BT-GMZ bound to purified yeast HSP82 (homologue to mammalian HSP90AB1) and EEF1A1, but not to TEF3 or HBS1, and was competed by unlabeled gamendazole. However, gamendazole did not inhibit nucleotide binding by EEF1A1. Gamendazole binding to purified Saccharomyces cerevisiae HSP82 inhibited luciferase refolding and was not competed by the HSP90 drugs geldanamycin or novobiocin analogue, KU-1. Gamendazole elicited degradation of the HSP90-dependent client proteins AKT1 and ERBB2 and had an antiproliferative effect in MCF-7 cells without inducing HSP90. These data suggest that gamendazole may represent a new class of selective HSP90AB1 and EEF1A1 inhibitors. Testis gene microarray analysis from gamendazole-treated rats showed a marked, rapid increase in three interleukin 1 genes and Nfkbia (NF-kappaB inhibitor alpha) 4 h after oral administration. A spike in II1a transcription was confirmed by RT-PCR in primary Sertoli cells 60 min after exposure to 100 nM gamendazole, demonstrating that Sertoli cells are a target. AKT1, NFKB, and interleukin 1 are known regulators of the Sertoli cell-spermatid junctional complexes. A current model for gamendazole action posits that this pathway links interaction with HSP90AB1 and EEF1A1 to the loss of spermatids and resulting infertility