Infrared thermography to assess proliferation and involution of infantile hemangiomas: A prospective cohort study

IMPORTANCE Infantile hemangiomas (IHs) are common benign tumors of infancy that have the potential to interfere with vital organ function and cause permanent disfigurement. Currently, few objective and validated measures exist to assess IHs. Copyright 2014 American Medical Association. All rights reserved

Classic Kaposi's sarcoma treated with topical 0.5% timolol gel

Kaposi’s sarcoma (KS) is an angioproliferative disorder closely associated with human herpesvirus type 8. Classic KS is found mainly in elderly males, with lesions beginning slowly and insidiously on the distal lower extremities and occasionally on the hands. Although the disease is very rarely responsible for the death of the patient, there might be complications such as ulceration, bleeding and pain in nodules on pressure areas requiring treatment (1). To date, a uniformly effective and low-risk treatment for KS has not been found, so therapeutic recommendations must be individualized

Resolution of Conjunctival Sessile Hemangioma With Topical Timolol

PURPOSE: To report a single case of acquired sessile hemangioma of the conjunctiva which resolved after treatment with topical timolol. METHODS: Case report and literature review. RESULTS: A 77-year old African-American woman developed an acquired sessile hemangioma of the conjunctiva of the right eye. She was followed for primary open-angle glaucoma, and the lesion was monitored for 12 months without change. Topical timolol-dorzolamide was then added to her glaucoma medication regimen twice daily. On follow-up examination 6 months later, the lesion had completely resolved. CONCLUSION: In this case report, an acquired sessile hemangioma of the conjunctiva resolved with topical timolol therapy

Effect of Transition Metal Fragments on the Reverse Fritsch–Buttenberg–Wiechell Type Ring Contraction Reaction of Metallabenzynes to Metal–Carbene Complexes

Metallabenzynes (<b>1M</b>), contrary to their organic analogues, benzynes, undergo ring-contraction to metal–carbene complexes (<b>2M</b>) via a reverse Fritsch–Buttenberg–Wiechell (FBW) type rearrangement. A detailed computational quantum mechanical study has been carried out to understand the effect of different third row transition metal fragments (ML₂L′₂; M = W, Re, Os, Ir, Pt; L/L′ = PH₃, Cl, CO) on the stability of metallabenzynes and their reactivity toward reverse FBW type rearrangement. Our results indicate that the late transition metal fragments Ir­(PH₃)­Cl₃ and PtCl₄ prefer 16 VE metal–carbene complex (<b>2M</b>), while the middle transition metal fragments W­(PH₃)₄, Re­(PH₃)₃Cl, and Os­(PH₃)₂Cl₂ prefer metallabenzyne (<b>1M</b>). This can be attributed to the reduced overlap between the transition metal fragment ML₂L′₂ and organic fragment C₅H₄ in metallabenzyne <b>1M</b> when M changes from W to Pt. Furthermore, the presence of a π-accepting ligand CO on the metal fragment makes the conversion of <b>1M</b> to <b>2M</b> more feasible