Comparative evaluation of the effects of bimaxillary and mandibular setback surgery on pharyngeal airway space and hyoid bone position in skeletal class III patients

To compare the effects of bimaxillary surgery ( Maxillary advancement and mandibular setback) and mandibular setback surgery (Bilateral Sagittal Split Osteotomy) on the pharyngeal airway space (PAS) and the hyoid bone position in a skeletal class III pat

A retrospective study: twin gestation at tertiary care, maternal and fetal outcome

Background: The objective of our study was to study the maternal and neonatal outcome in twin gestation in a tertiary care center.Methods: A retrospective analysis of 197 twin pregnancies admitted and managed at M S Ramaiah medical college. Parameters in the mother and fetus were studied for any adverse antenatal complications, mode of delivery.Results: Prim gravid patients with twin pregnancy constituted (45.6%). 4.5% of patients had an IVF conception. 45.1% patients were unbooked to our institute, 82% of the unbooked patients presented with preterm labour and preterm premature rupture of membrane. PIH was noted in 32.9% of the patients, premature rupture of membranes (32.9%), Intra- Uterine Death of one fetus (6.09%) and intra uterine growth retardation (2.03%) was the antenatal complications observed. Out of the 197 patients 63 (31.97%) delivered by vaginal route whereas 134 (68.02%) had to undergo cesarean section. Section for the second twin was done in 4(2.03%). The 197 women of twin pregnancy gave birth to 378 live-born babies, 16(9.5%) stillborn and 32 (16.2%) died by the end of seven days due to complications related to prematurity: hyaline membrane disease, hyperbilirubinemia.Conclusions: Early active intervention in twin gestation can reduce the maternal and fetal mortality and morbidity

Amphiphilic Block Copolymers: Application in Gene Delivery and In-vitro Biological Evaluation

Gene therapy holds a great promise in the treatment of acquired genetic disorders such as cancer because it shows fewer side effects compared to chemotherapy. In order for gene therapy to be successful, however, it is crucial to develop efficient and non-toxic gene carriers to overcome poor in vivo stability and low cellular uptake of nucleic acid therapeutic agents. My Master’s thesis research mainly focuses on the development of a new approach exploring a combination of hydrophobic modification with stimuli-responsive degradation (SRD) to synthesize novel amphiphilic block copolymer-based nanocarriers for controlled gene delivery. The block copolymer synthesized by atom transfer radical polymerization is designed with an acid-labile acetal linkage at the block junction and pendant disulfide group in a hydrophobic block. The incorporation of labile linkages enables both dual-location dual-acid/reduction-responsive degradation (DL-DSRD) and in situ disulfide-core-crosslinking. Further, the disulfide pendants integrated as hydrophobic moieties facilitate to condense the nucleic acids into nanometer-sized micelleplexes through electrostatic interaction of pendant dimethylamino groups with the anionic phosphate groups of the nucleic acids. Our results demonstrate that the hydrophobic modification approach through DL-DSRD is a robust platform in the development of gene delivery systems with enhanced colloidal stability, reduced cytotoxicity, and improved gene transfection efficiency. Further, my research is interested in the biological evaluation of delivery nanocarriers to investigate their cellular interactions with various biological systems for tumor-targeted delivery. Four SRD-exhibiting amphiphilic block copolymer micelles were chosen for not only their various chemical compositions but also different positions of labile linkages cleavable in response to acidic pH and glutathione. The results from cytotoxicity and cellular uptake assays reveal that polymer composition and arrangement of monomers play an important role to determine the biological fate of SRD-exhibiting nanocarriers

Role of mini-scleral lens in mucous membrane pemphigoid

This study aims to report the use of mini-scleral contact lens in the management of mucous membrane pemphigoid (MMP) with persistent epithelial defects. A 68-year-old male with a history of ocular pain and declining visual acuity was referred to our clinic with a diagnosis of MMP. His corrected distance visual acuity (CDVA) was 20/200 in the right eye and 20/100 in the left eye. Despite being on lubricants, topical steroids and intravenous cyclophosphamide, the patient developed persistent corneal epithelial defects in both eyes. He was then given a trial of mini-scleral lenses. Within 4 weeks, corneal epithelial defects healed, and at 6 months, the CDVA had improved to 20/50 in the right eye and 20/40 in the left eye. By improving the corneal surface integrity and visual function, mini-scleral lenses can play a role in the visual rehabilitation of patients with MMP

The nomadic Ozurdex®: Anterior migration of the dexamethasone implant and back!

Dexamethasone intravitreal implantation has been used in various retinal and uveal pathologies. Common complications include cataract formation and raised intraocular pressure. Although uncommon, migration of the implant has also been well reported. We describe a case with migration of the implant into the anterior chamber in a patient with a scleral-fixated intraocular lens, which was managed noninvasively by pupillary dilatation and positioning of the patient

A retrospective study: twin gestation at tertiary care, maternal and fetal outcome

Background: The objective of our study was to study the maternal and neonatal outcome in twin gestation in a tertiary care center.Methods: A retrospective analysis of 197 twin pregnancies admitted and managed at M S Ramaiah medical college. Parameters in the mother and fetus were studied for any adverse antenatal complications, mode of delivery.Results: Prim gravid patients with twin pregnancy constituted (45.6%). 4.5% of patients had an IVF conception. 45.1% patients were unbooked to our institute, 82% of the unbooked patients presented with preterm labour and preterm premature rupture of membrane. PIH was noted in 32.9% of the patients, premature rupture of membranes (32.9%), Intra- Uterine Death of one fetus (6.09%) and intra uterine growth retardation (2.03%) was the antenatal complications observed. Out of the 197 patients 63 (31.97%) delivered by vaginal route whereas 134 (68.02%) had to undergo cesarean section. Section for the second twin was done in 4(2.03%). The 197 women of twin pregnancy gave birth to 378 live-born babies, 16(9.5%) stillborn and 32 (16.2%) died by the end of seven days due to complications related to prematurity: hyaline membrane disease, hyperbilirubinemia.Conclusions: Early active intervention in twin gestation can reduce the maternal and fetal mortality and morbidity

Optical Aberrations- A Trigger Factor For Migraine

"Migraine is a neurovascular disorder encompassing a wide clinical spectrum of signs and symptoms. The objective of this study was to evaluate whether aberrations of the eye can be trigger factors for migraine.