Occupational Therapy Students\u27 Perceptions of their own Notetaking

Purpose: Notetaking is a critical skill for higher-level thinking and information integration in graduate students, including occupational therapy students. Though there is a growing body of literature about notetaking modalities, strategies utilized, and self-perceptions of skills in college students, studies about occupational therapy (OT) students’ notetaking preferences have been absent from the literature. This study examines how OT students take notes and their perceptions of their notes. Method: This descriptive study of students in a Master of Occupational Therapy program (n=57) completed the Notetaking Abilities and Strategies of University Students (NASUS) questionnaire which captures the constructs of notetaking methods, reasons for taking notes, students’ opinions of their notes, satisfaction with notetaking and usefulness of notes, students’ desires to change their notetaking methods, and organization and review of notes after class. Results: Study found that students utilized both handwritten and digital forms of notetaking, as expected, and took notes in class primarily as a resource to study for assessments and complete assignments as well as to remember information. Overall, students had a moderate degree of confidence and satisfaction with the usefulness of their notes and expressed a desire to improve their notetaking. Conclusions: Understanding the notetaking preferences of OT students can facilitate OT programs’ ability to support these students’ learning

All Work or All Play? The Impact of Cultural and Clinical Activities on Perceived Cultural Sensitivity Development During an Occupational Therapy Service Learning Experience

International service learning experiences provide invaluable opportunities for occupational therapy practitioners and students to practice clinical skills while also being exposed to different cultures and experiences not available in their home country. Studies have shown that clinical activities during international service learning experiences increase students’ cultural awareness and sensitivity, however the effect of cultural activities on students’ development is not known. Over the span of two years, multiple groups of American occupational therapy students traveled to Morocco for a ten day service learning experience and served in a variety of clinical activities across the lifespan and population. Students also participated in cultural and tourist activities for increased exposure to the local culture. This study explored the development of cultural sensitivity through participation in both clinical and cultural activities during the international service learning experience through a quantitative survey (n=22) and qualitative interview (n=17). Participants indicated that both clinical and cultural activities played a role in their self-perceived development of cultural sensitivity on the quantitative survey. Themes identified within the qualitative interview revealed the impactful qualities of various activities, identified as “Authenticity,” “Communication Skills,” “Role of Religion,” and “Exposure to Morocco.” It appears that both kinds of activities play a role in development of cultural sensitivity, and regardless of the activity, authenticity and exposure to the culture along with opportunities to practice communication skills play the largest role in students perceiving a personal increase in cultural awareness and sensitivity while participating in international service learning experiences

Visual Communication Design Collaboration with Occupational Therapy to Create Health Literacy Projects for Community Needs

Low levels of health literacy directly correlate to increased mortality rates, decreased health outcomes and overall poorer quality of life. Many social determinants of health can place someone at a higher risk of low health literacy and the negative consequences of decreased skills in this area. Health literacy is a complex task that requires a multi-modal approach and interventions within a variety of spheres of influence in someone’s life. To address this issue in underinvested communities within their own city, teams of Visual Communication Design and Occupational Therapy students, with the support of their faculty and a librarian, worked together to identify a population of interest and pertinent health-related concerns. The result was an interdisciplinary team of students who utilised aspects of the Social Ecology Theory to create solutions and systems that utilised printed and digital modalities at the individual and community levels. This case study offers a model for interdisciplinary collaboration to address health literacy and improve the health outcomes of the population concerned

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Integrated genomic characterization of pancreatic ductal adenocarcinoma

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies