Tissue Tropism and Target Cells of NSs-Deleted Rift Valley Fever Virus in Live Immunodeficient Mice

Rift Valley fever, caused by a member of the Bunyaviridae family, has spread during recent years to most sub-Saharan African countries, in Egypt and in the Arabian peninsula. The virus can be transmitted by insect vectors or by direct contacts with infectious tissues. The analysis of virus replication and dissemination in laboratory animals has been hampered by the need to euthanize sufficient numbers of animals and to assay appropriate organs at various time points after infection to evaluate the viral replication. By following the bioluminescence and fluorescence of Rift Valley fever viruses expressing light reporters, we were able to track the real-time dissemination of the viruses in live immunodeficient mice. We showed that the first infected organs were the thymus, spleen and liver, but the liver rapidly became the main location of viral replication. Phagocytes also appeared as important targets, and their systemic depletion by use of clodronate liposomes decreased the number of viruses in the blood, delayed the viral dissemination and prolonged the survival of the infected mice

A Purity Monitoring System for the H1 Liquid Argon Calorimeter

The ionization probes used for monitoring the liquid argon purity in the H1 calorimeter are described and results of their operation in tests at CERN and during the period 1992 to the end of 1998 at HERA are given. The high sensitivity of the charge measurements leads to refined charge collection models, and to the observation of a variation of the ionization yield of our electron sources with temperature.Comment: 26 pages, 14 figure

Revue des Revues

Gareau Jean-François, Bodeau Pierre, Canal Grégory, De Frouville Olivier, Eisemann Pierre Michel, Guillot Philippe, Henchoz Alain-Denis, Kohen Marcelo G., Mbengue Makana Moïse, Pellet Alain, Renaut Céline. Revue des Revues. In: Annuaire français de droit international, volume 48, 2002. pp. 908-944

Revue des Revues

Gareau Jean-François, Bodeau Pierre, Canal Grégory, De Frouville Olivier, Eisemann Pierre Michel, Guillot Philippe, Henchoz Alain-Denis, Kohen Marcelo G., Mbengue Makana Moïse, Pellet Alain, Renaut Céline. Revue des Revues. In: Annuaire français de droit international, volume 48, 2002. pp. 908-944

Revue des Revues

Gareau Jean-François, Canal Grégory, De Frouville Olivier, Desgagné Richard, Eisemann Pierre Michel, Guillot Philippe, Henchoz Alain-Denis, Kohen Marcelo G., Mbengue Makana Moïse, Nesi Giuseppe, Pellet Alain, Quéguiner Jean-François, Renaut Céline, Tavernier Paul, Villalpando Santiago. Revue des Revues. In: Annuaire français de droit international, volume 47, 2001. pp. 707-769

Revue des Revues

Gareau Jean-François, Canal Grégory, De Frouville Olivier, Desgagné Richard, Eisemann Pierre Michel, Guillot Philippe, Henchoz Alain-Denis, Kohen Marcelo G., Mbengue Makana Moïse, Nesi Giuseppe, Pellet Alain, Quéguiner Jean-François, Renaut Céline, Tavernier Paul, Villalpando Santiago. Revue des Revues. In: Annuaire français de droit international, volume 47, 2001. pp. 707-769

Revue des revues

Boisson de Chazournes Laurence, Gareau Jean-François, Barbier Sandrine, Benlolo Myriam, Bodeau-Livinec Pierre, Capette Isabelle, Canal Grégory, Darribehaude François, Desgagné Richard, Eisemann Pierre Michel, Frouville Olivier de, Guillot Philippe Ch.-A., Henchoz Alain-Denis, Kohen Marcelo G., Pellet Alain, Quéguiner Jean-François, Renaut Céline, Tavernier Paul, Villalpando Santiago. Revue des revues. In: Annuaire français de droit international, volume 46, 2000. pp. 940-991