High order three part split symplectic integrators: Efficient techniques for the long time simulation of the disordered discrete nonlinear Schroedinger equation

While symplectic integration methods based on operator splitting are well established in many branches of science, high order methods for Hamiltonian systems that split in more than two parts have not been studied in great detail. Here, we present several high order symplectic integrators for Hamiltonian systems that can be split in exactly three integrable parts. We apply these techniques, as a practical case, for the integration of the disordered, discrete nonlinear Schroedinger equation (DDNLS) and compare their efficiencies. Three part split algorithms provide effective means to numerically study the asymptotic behavior of wave packet spreading in the DDNLS - a hotly debated subject in current scientific literature.Comment: 5 Figures, Physics Letters A (accepted

Probing the local dynamics of periodic orbits by the generalized alignment index (GALI) method

As originally formulated, the Generalized Alignment Index (GALI) method of chaos detection has so far been applied to distinguish quasiperiodic from chaotic motion in conservative nonlinear dynamical systems. In this paper we extend its realm of applicability by using it to investigate the local dynamics of periodic orbits. We show theoretically and verify numerically that for stable periodic orbits the GALIs tend to zero following particular power laws for Hamiltonian flows, while they fluctuate around non-zero values for symplectic maps. By comparison, the GALIs of unstable periodic orbits tend exponentially to zero, both for flows and maps. We also apply the GALIs for investigating the dynamics in the neighborhood of periodic orbits, and show that for chaotic solutions influenced by the homoclinic tangle of unstable periodic orbits, the GALIs can exhibit a remarkable oscillatory behavior during which their amplitudes change by many orders of magnitude. Finally, we use the GALI method to elucidate further the connection between the dynamics of Hamiltonian flows and symplectic maps. In particular, we show that, using for the computation of GALIs the components of deviation vectors orthogonal to the direction of motion, the indices of stable periodic orbits behave for flows as they do for maps.Comment: 17 pages, 9 figures (accepted for publication in Int. J. of Bifurcation and Chaos

Numerical integration of variational equations

We present and compare different numerical schemes for the integration of the variational equations of autonomous Hamiltonian systems whose kinetic energy is quadratic in the generalized momenta and whose potential is a function of the generalized positions. We apply these techniques to Hamiltonian systems of various degrees of freedom, and investigate their efficiency in accurately reproducing well-known properties of chaos indicators like the Lyapunov Characteristic Exponents (LCEs) and the Generalized Alignment Indices (GALIs). We find that the best numerical performance is exhibited by the \textit{`tangent map (TM) method'}, a scheme based on symplectic integration techniques which proves to be optimal in speed and accuracy. According to this method, a symplectic integrator is used to approximate the solution of the Hamilton's equations of motion by the repeated action of a symplectic map $S$, while the corresponding tangent map $TS$, is used for the integration of the variational equations. A simple and systematic technique to construct $TS$ is also presented.Comment: 27 pages, 11 figures, to appear in Phys. Rev.

High order three part split symplectic integrators: Efficient techniques for the long time simulation of the disordered discrete nonlinear Schrödinger equation

While symplectic integration methods based on operator splitting are well established in many branches of science, high order methods for Hamiltonian systems that split in more than two parts have not been studied in great detail. Here, we present several high order symplectic integrators for Hamiltonian systems that can be split in exactly three integrable parts. We apply these techniques, as a practical case, for the integration of the disordered, discrete nonlinear Schrödinger equation (DDNLS) and compare their efficiencies. Three part split algorithms provide effective means to numerically study the asymptotic behavior of wave packet spreading in the DDNLS – a hotly debated subject in current scientific literature

Nuclear receptors in vascular biology

Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate, cholesterol, and xenobiotic drug metabolism, inflammation, cell differentiation and development, including vascular development. The nuclear receptor family is one of the most important groups of signaling molecules in the body and as such represent some of the most important established and emerging clinical and therapeutic targets. This review will highlight some of the recent trends in nuclear receptor biology related to vascular biology

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

Radiation-induced midbrain fibrosarcoma is a rare, highly aggressive tumor, which is associated with poor prognosis. We present the case of a 48-year old man with brainstem fibrosarcoma 20 years following radiation therapy received for a pituitary tumor. We discuss this case in the context of the diagnostic criteria for these tumors, and previous reports of secondary and primary sarcomas of the central nervous system