From the Field into the Lab: Useful Approaches to Selecting Species Based on Local Knowledge

Ethnopharmacological field studies are indispensable for identifying plants that can be selected for their pharmacological effects and chemical composition. Although the subjective interpretation of results by the researcher is crucial, quantitative data analysis is a useful tool to identify the most promising pharmacological plants. It has been stated that such semi-quantitative information increases the likelihood of finding promising ethnopharmacological leads, but so far no critical review has assessed what standards best meet the requirements of biomedical research. Systematic database searches using SCOPUS, Science Direct, Web of Knowledge, Science Citation Index, and Medline with the keywords “ethnobotany,” “ethnopharmacology,” “index,” and “consensus” in research from the last 5 years form the basis of the current analysis, which identifies particularly useful tools like factor of informant consensus, fidelity level, use-value, and relative importance. A key feature for further field studies is that they should provide clear information on a range of topics like; detailed data of the importance of these resources within a culture, data of the uses of the species, how and where the plants are collected, drying and storage processes, preparation method, used doses, and administration. In addition, they must include a collection of records about how the people feel after the plant use, disappearance of specific symptoms and possible side effects

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Mesoamerica is well known for the Mayan civilization, which flourished in this region during pre-Columbian times and made use of plant diversity for medicinal purposes. Currently, there are 21 Mayan ethnic groups in Guatemala, including the Q'eqchi'. The use of medicinal plants is still prevalent among them, they have been an important medicinal source for the population. The present study aims to compile traditional knowledge of the use of medicinal plants from three Q'eqchi' communities in Alta Verapaz, Guatemala and identify the important medicinal plants that are currently being used to treat relevant diseases. The study also aims to determine the relative importance of the identified species to propose new species for further pharmacological studies. Based on the cultural richness and the low level of perturbation of the vegetation, we selected the Q'eqchi' communities of Sanimtaqá, Santo Domingo de las Cuevas, and Chirrepec in Alta Verapaz, Guatemala. There, semi-structured interviews were conducted between June 2013 and December 2014 with common people. Plant-related questions and certain sociocultural contexts of the informants were included. Herbarium specimens for identification were collected with the help of the informants in their gardens with people from each community. The data were analyzed in two forms, the first non-quantitative based on the interpretation of the interviews (emic concepts of diseases) the second by following quantitative methods: informant consensus factor (Fic), Friedman's fidelity index (Fl), and use-reports (Ur). A total of 169 interviews were conducted. One hundred thirty-seven species of plants with medicinal uses were identified, which were described 2,055 times. These species belong to 59 families and 117 genera. Gastrointestinal conditions and pain/fever had the highest number of plant species uses for treatment. The main gastrointestinal conditions included diarrhea (Nume'sa'), stomach pain and worms (Luqum), while the pain/fever classification included headaches (rail jolom), and fevers (Tiq'). The most important cultural condition is called Chaquiq'yaj, the symptoms of the disease; diarrhea, vomiting, fever, lack of appetite, and thirst could be associated with a gastrointestinal. Conclusions: After analyzing the data, we can conclude that; Ageratina ligustrina, Catopheria chiapensis, Baccharis inamoena, Peperomia maculosa, Baccharis salicina, Clinopodium brownei, Calea integrifolia, and Smallanthus maculatus var. maculatus are the most culturally relevant species

Editorial: Neglected diseases in Africa: a challenge for medicinal plants research

No Abstract Available Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 213 – 21

Hypoglycemic effect of Acosmium panamense bark on streptozotocin diabetic rats

The hypoglycemic effects of water and butanolic extracts prepared from the bark of Acosmium panamense (Fabaceae) were studied in diabetic rats (streptozotocin (STZ)-induced). Oral application of water extracts at doses of 20 and 200 mg/kg and of butanol extracts at doses of 20 and 100 mg/kg significantly lowered the plasma glucose levels in diabetic rats within 3 h. Glibenclamide was used as reference and showed similar hypoglycemic effect like the extracts. Three structurally new compounds were isolated from the plant and shown to be the main constituents in both extracts. (C) 2003 Elsevier Ireland Ltd. All rights reserved

Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats

The hypoglycemic effects of water and butanolic extracts prepared from leaves of Cecropia obtusifolia (Cecropiaceae) were examined in streptozotocin induced diabetic rats. A single oral administration of a water extract at doses of 90 and 150 mg/kg and of a butanol extract at doses of 9 and 15 mg/kg significantly (P < 0.05) lowered the plasma glucose levels in diabetic rats after 3 h administration. Glibenclamide was used as reference and showed similar hypoglycemic effect to the tested extracts at a dose of 3 mg/kg. The flavone, isoorientin and 3-caffeoylquinic acid (chLorogenic acid), were isolated as the important constituents of the plant and were identified as the main constituents in both extracts, too. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved

Pyrrolizidine alkaloids from Ageratum houstonianum Mill

Four pyrrolizidine alkaloids (PA) were isolated from Ageratum houstonianum and their structures elucidated by spectroscopical methods. Besides the already known lycopsamine three new PA were found. Their structures are the 2S-2-hydroxy-2,3-dimethylbutanoyl-O-9 as well as the O-7 esters of retronecine and the O-9 derivative of heliotridine. (C) 2001 Elsevier Science Ltd. All rights reserved

Mexican plants with hypoglycaemic effect used in the treatment of diabetes

Diabetes mellitus is a syndrome which affects more and more people in all countries over the world. In México, it is commonly treated with herbal extracts. Such treatment may be of considerable benefit especially during the early stages of the illness. In this review, we discuss species commonly used in México in the treatment of diabetes. A total of 306 species have records of a popular use in the treatment of this syndrome in México. Seven of these species – Cecropia obtusifolia Bertol. (Cecropiaceae), Equisetum myriochaetum Schlecht & Cham (Equisetaceae), Acosmium panamense (Benth.) Yacolev (Fabaceae), Cucurbita ficifolia Bouché (Cucurbitaceae), Agarista mexicana (Hemsl.) Judd. (Ericaeae), Brickellia veronicaefolia (Kunth) A. Gray (Asteraceae), Parmentiera aculeata (Kunth) Seem. (Bignoniaceae) – are discussed in greater detail, highlighting our current knowledge about these botanicals, but also the enormous gaps in our knowledge, most notably as it relates to the species’ toxicology, the pharmacokinetics of its active constituents and their metabolism