Beam-Material Interaction

Th is paper is motivated by the growing importance of better understanding of the phenomena and consequences of high- intensity energetic particle beam interactions with accelerator, generic target , and detector components. It reviews the principal physical processes of fast-particle interactions with matter, effects in materials under irradiation, materials response, related to component lifetime and performance, simulation techniques, and methods of mitigating the impact of radiation on the components and envir onment in challenging current and future applicationComment: 28 pages, contribution to the 2014 Joint International Accelerator School: Beam Loss and Accelerator Protection, Newport Beach, CA, USA , 5-14 Nov 201

Metacognition and headache: which Is the role in childhood and adolescence?

Headache, in particular migraine, is one of the most frequent neurological symptoms in children and adolescents and it affects about 60% of children and adolescents all over the world. Headache can affect several areas of child’s functioning, such as school, physical activities, peer, and family relationship. The global and severe burden of this disease requires a multidisciplinary strategy and an effective treatment addressed all of the patient’s needs and based on cutting-edge scientific research. In recent years, research has focused on cognitive factors specifically in functions called metacognitive processes. Metacognition can be defined as the knowledge, beliefs, and cognitive processes involved in monitoring, control, and assessment of cognition. Metacognition seems to be closely related to the ability of theory of mind, the ability to infer, and reason about the mental states of other people in order to predict and explain own behavior. Recent studies found a relationship between metacognitive skills and anxiety, depression, motivation, academic performance, human social interactions, and stress symptoms. This relationship is very interesting for headache treatment, because these factors are the most commonly reported triggers in this disorder and there is a high comorbidity with anxiety and depression in children and adolescents with headache. So, headache and these comorbidities, in particular anxiety and depression, may have in common persistent and maladaptive patterns of thinking which are related to maladaptive metacognitive beliefs. Further research should assess metacognitive processes of children and adolescents with headache in order to increase their ability to control their own cognitive processes and consequently monitor factors which may trigger the attacks

Headache and alexithymia in children and adolescents: what Is the connection?

Background: Headache is one of the most common complaints in children and adolescents and comorbidity rates are very high and the major associated diseases are depression, anxiety, atopic disorders, sleep, and behavioral disorders. In recent years, it has been highlighted that difficulties regulating emotions such as alexithymia have also been associated with diagnosis of somatization. Methods: We carried out a mini review analyzing the relation between alexithymia and primary headache (e.g., migraine and tension type headache) in children and adolescents by synthesizing the relevant studies in the literature on PubMed, PsycINFO, and Google Scholar. Search terms were "alexithymia" combined with the "primary headache," "migraine," "tension type headache," "children," and "adolescents." Results: All analyzed studies found higher levels of alexithymia in children and adolescents with headache than control groups but there are different opinions about the relationship between headache and alexithymia. For example, some studies suggest that the association between headache and alexithymia in children may be due to an incomplete development of emotive competency or a general immature cognitive development, instead other studies found a correlation between headache symptoms, insecure attachment, and alexithymia. There seems to be also differences between children with migraine compared to those with tension type headache (TTH). Conclusion: There are some studies on adults suffering from headache or migraine and alexithymia, but there is only a moderate amount of research on pediatric age with different opinions and theories about this relationship. Further studies on children and adolescents are necessary to effectively understand this relationship and to help children to reduce headache and improve emotional consciousness

Don't judge a book by its cover. factitious disorder imposed on children-report on 2 cases

Factitious Disorder Imposed on Another (FDIA), also known as Munchausen Syndrome by Proxy (MSbP) is a very serious form of child abuse. The perpetrator, usually the mother, invents symptoms or causes real ones in order to make her child appear sick. Usually this is due to a maladaptive disorder or to an excessive of attention-seeking on her part. We report here two new cases of FDIA. The first one is a 9-year-old boy with a history of convulsive episodes, reduced verbal production, mild psychomotor disorder and urological problems who underwent several invasive procedures and hospitalizations before a diagnosis of FDIA was made. The second is a 12 year-old girl with headache, abdominal pain, lipothymic episodes, seizures and a gait impairment, who was hospitalized in several hospitals before an FDIA was diagnosed

Hadronic interactions of primary cosmic rays with the FLUKA code

The measured fluxes of secondary particles produced by the interactions of cosmic rays with the astronomical environment represent a powerful tool to infer some properties of primary cosmic rays. In this work we investigate the production of secondary particles in inelastic hadronic interactions between several cosmic rays species of projectiles and different target nuclei of the interstellar medium. The yields of secondary particles have been calculated with the FLUKA simulation package, that provides with very good accuracy the energy distributions of secondary products in a large energy range. An application to the propagation and production of secondaries in the Galaxy is presented.Comment: 8 pages, 4 figures; Contribution to the 34th International Cosmic Ray Conference, July 30 to August 6, The Hague, Netherlands; fixing a typo in the y-axis label of Fig.

Distribution of inorganic and organic nutrients in the South Pacific Ocean – evidence for long-term accumulation of organic matter in nitrogen-depleted waters

International audienceThe BIOSOPE cruise of the RV Atalante was devoted to study the biogeochemical properties in the South Pacific between the Marquesas Islands (141° W–8° S) and the Chilean upwelling (73° W–34° S). The 8000 km cruise had the opportunity to encounter different trophic situations, and especially strong oligotrophic conditions in the Central South Pacific Gyre (SPG, between 123° W and 101° W). In this isolated region, nitrate was undetectable between surface and 160–180 m, while regenerated nitrogen (nitrite and ammonium) only revealed some traces (-1), even in the subsurface maximum. Integrated nitrate over the photic layer, which reached 165 m, was close to zero. In spite of this severe nitrogen-depletion, phosphate was always present at significant concentrations (˜0.1 µmoles l-1), while silicate maintained at low but classical oceanic levels (˜1 µmoles l-1). In contrast, the Marquesas region (MAR) at west and Chilean upwelling (UPW) at east were characterized by large nutrient contents one hundred to one thousand fold higher than in the SPG. Distribution of surface chlorophyll concentration reflected this gradient of nitrate availability. The lowest value (0.023 nmoles l-1) was measured in the centre of the SPG, where integrated chlorophyll over the photic layer was very weak (˜10 mg m-2), since a great part (up to 50%) of the deep chlorophyll maximum (DCM) was located below the 1% light. But, because of the relative high concentration encountered in the DCM (0.2 µg l-1), chlorophyll a content over the photic layer varied much less (by a factor 2 to 5) than the nitrate content. In contrast to chlorophyll a, integrated content of particulate organic matter (POM) remained more or less constant along the investigated area (500 mmoles m-2, 60 mmoles m-2 and 3.5 mmoles m-2 for particulate organic carbon, particulate organic nitrogen and particulate organic phosphorus, respectively), except in the upwelling where values were two fold higher. Extensive comparison has shown that glass fiber GF/F filters efficiency collected particulate chlorophyll, while a significant fraction of POM (up to 50%) passed trough this filter and was retained by 0.2 µm Teflon membrane. The most striking feature was the large accumulation of dissolved organic matter (DOM) in the SPG relative to surrounding waters, especially dissolved organic carbon (DOC) where concentrations were at levels rarely measured in oceanic waters (>100 µmoles l-1). Due to this large pool of DOM over the whole photic layer of the SPG, integrated values followed an opposite geographical pattern than this of inorganic nutrients with a large accumulation within the centre of the SPG. While suspended particulate matter in the mixed layer had C/N ratio largely conform to Redfield stoichiometry (C/N˜6.6), marked deviations were observed in this excess DOM (C/N˜16 to 23). The existence of C-rich dissolved organic matter is recognized as a feature typical of oligotrophic waters, requiring the over consumption of carbon. Thus, in spite of strong nitrate-depletion leading to low chlorophyll biomass, the closed ecosystem of the SPG can produce a large amount of carbon. The implications of this finding are discussed, the conclusion being that, due to the lack of seasonal vertical mixing and weak lateral advection, the dissolved organic carbon biologically produced can be accumulated and stored in the photic layer for a very long period

Energy deposition studies for the High-Luminosity Large Hadron Collider inner triplet magnets

A detailed model of the High Luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the FLUKA and MARS15 codes. In the optimized configuration, the peak power density averaged over the magnet inner cable width is safely below the quench limit. For the integrated luminosity of 3000 fb-1, the peak dose in the innermost magnet insulator ranges from 20 to 35 MGy. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. In general, FLUKA and MARS results are in a very good agreement.Comment: 24 p

Energy Deposition Studies for the Hi-Lumi LHC Inner Triplet Magnets

A detailed model of the High Luminosity LHC inner triplet region with new large-aperture Nb3Sn magnets, field maps, corrector packages, and segmented tungsten inner absorbers was built and implemented into the FLUKA and MARS15 codes. In the optimized configuration, the peak power density averaged over the magnet inner cable width is safely below the quench limit. For the integrated luminosity of 3000 fb -1, the peak dose in the innermost magnet insulator ranges from 20 to 35 MGy. Dynamic heat loads to the triplet magnet cold mass are calculated to evaluate the cryogenic capability. In general, FLUKA and MARS results are in a very good agreement.Comment: 4 pp. Presented paper at the 5th International Particle Accelerator Conference, June 15 -20, 2014, Dresden, German

Related RNAs in lepidopteran cells after in vitro infection with Hyposoter didymator virus define a new polydnavirus gene family

In the present study, we describe the isolation and the characterization of three different Hyposoter didymator virus (HdV) lepidopteran host-expressed genes, the products of which might interfere with the host physiology during parasitism. In this report, we study the expression of HdV genes in Sf9 cells infected with HdV since results indicate that the Sf9 model mimics to some extent the in vivo model and may be utilized to study expression of HdV genes in lepidopteran host cells. This system allowed us to isolate three HdV-specific cDNAs, termed M24, M27, and M40. cDNA nucleotide sequence analysis demonstrated significant regions of homology. The three cDNAs displayed repeated sequences arranged in tandem array that might have evolved through domain duplication. Similar to other previously described polydnavirus host-expressed genes, two intron positions have been found in the M24 leader region. The cDNAs corresponded to RNAs of 1.6, 1.6, and 2.3 kb that are also detected in parasitized Spodoptera littoralis larvae. They are encoded by different genes likely located on different HdV DNA molecules. Corresponding RNAs are detected early postinfection and remain detectable for at least 10 days postinfection. They encode secreted glycine- and proline-rich proteins. An antiserum raised against a baculovirus recombinant M24-encoded protein detected similar proteins in the culture medium of infected lepidopteran cells and in parasitized host hemolymph. We propose that the three cloned genes belong to an HdV gene family specifically expressed in parasitized lepidopteran hosts, (C) 1999 Academic Press

One Click to Suicide: First Amendment Case Law and its Applicability to Cyberspace

Thesis advisor: Dale HerbeckWebsites counseling dangerous activity such as suicide represent uncharted legal territory. To date, most legal scholarship regarding these sites considers whether they incite imminent lawless action. As an alternative to incitement, this paper argues that these websites are more productively characterized as instruction manuals that aid and abet unlawful activity. In support of this approach, this paper proposes a three-tiered legal test for distinguishing between protected and unprotected instruction manuals under the First Amendment.Thesis (BA) — Boston College, 2010.Submitted to: Boston College. College of Arts and Sciences.Discipline: Communication Honors Program.Discipline: Communication