Mohs micrographic surgery: a study of 83 cases Cirurgia micrográfica de Mohs: estudo de 83 casos

BACKGROUND: Mohs micrographic surgery can achieve high cure rates in the treatment of skin cancer and remove a minimum of healthy tissue. OBJECTIVES: To characterize patients undergoing Mohs micrographic surgery and study issues related to the number of surgical stages. METHODS: A descriptive, retrospective, cross-sectional study was conducted in a micrographic surgery reference center for the period of 2004 to 2010. Data was collected from medical records of 79 patients (83 surgeries). RESULTS: We studied 43 women and 36 men. The mean age was 57.5 ± 14,6 years. Skin types II and III were the most frequent, accounting for 41% and 36.1%, respectively. The most frequent tumor was the basal cell carcinoma (89.1%), and the solid subtype was the most common (44.6%), followed by sclerodermiform histological subtype (32%).The most frequent location was the nasal region (44.6%). The large majority of the operated tumors were recurrent lesions (72.7%). Half of the tumors measured 2 cm or more. In 68.7% of the cases two or more surgical stages were necessary for the removal of the tumors. The observation period was 2 or more years in 75% of the tumors. There was 01 post-Mohs recurrence and 02 patients had metastases during the observation period (both with squamous cell carcinoma). CONCLUSION: The findings coincide with those of the literature, recurrent tumors and tumors larger than 2cm needed more surgical stages for their removal, although there was no statistic difference (p=0,12 and 0,44 respectively).<br>FUNDAMENTOS: A cirurgia micrográfica de Mohs é capaz de alcançar altas taxas de cura no tratamento do câncer de pele e remover o mínimo possível de tecido saudável. OBJETIVOS: caracterizar os pacientes submetidos à cirurgia micrográgica de Mohs e estudar aspectos relacionados ao número de fases cirúrgicas. MÉTODOS: trata-se de estudo observacional, transversal e descritivo realizado em serviço de referência para cirurgia micrográfica no período de 2004 a 2010. Foram revisados os prontuários de 79 pacientes (83 cirurgias). RESULTADOS: Foram avaliados 43 mulheres e 36 homens. A média de idade foi 57,5 ± 14,6 anos. Os fototipos II e III foram os mais frequentes, respondendo por 41% e 36,1% respectivamente. O tumor mais freqüente foi o carcinoma basocelular (89,1%), sendo o subtipo sólido o mais frequente (44,6%), seguido pelo esclerodermiforme (32%). A localização mais freqüente foi a nasal (44,6%). A grande maioria dos tumores operados eram recidivados (72,7%). Metade dos tumores mediam 2 cm ou mais. Foram necessárias duas ou mais fases cirúrgicas em 68,7% dos tumores para sua remoção. O tempo de acompanhamento foi igual ou superior a 2 anos em 75%. Houve 01 recidiva pós-Mohs e 02 pacientes apresentaram metástases durante o estudo (ambos carcinomas espinocelulares). CONCLUSÕES: Os achados coincidem com os da literatura, sendo que tumores recidivados e maiores que 2cm necessitaram de mais fases cirúrgicas para sua completa remoção, apesar de não haver diferença estatística (p=0,12 e 0,44, respectivamente)

Development of a core outcome set for cutaneous squamous cell carcinoma trials: identification of core domains and outcomes

BackgroundThe lack of uniformity in the outcomes reported in clinical studies of the treatment of cutaneous squamous cell carcinoma (cSCC) complicates efforts to compare treatment effectiveness across trials.ObjectivesTo develop a core outcome set (COS), a minimum set of agreed-upon outcomes to be measured in all clinical trials of a given disease or outcome, for the treatment of cSCC.MethodsOne hundred and nine outcomes were identified via a systematic literature review and interviews with 28 stakeholders. After consolidation of this long list, 55 candidate outcomes were rated by 19 physician and 10 patient stakeholders, in two rounds of Delphi exercises. Outcomes scored 'critically important' (score of 7, 8 or 9) by ≥ 70% of patients and ≥ 70% of physicians were provisionally included. At the consensus meeting, after discussion and voting of 44 international experts and patients, the provisional list was reduced to a final core set, for which consensus was achieved among all meeting participants.ResultsA core set of seven outcomes was finalized at the consensus meeting: (i) serious or persistent adverse events, (ii) patient-reported quality of life, (iii) complete response, (iv) partial response, (v) recurrence-free survival, (vi) progression-free survival and (vii) disease-specific survival.ConclusionsIn order to increase the comparability of results across trials and to reduce selective reporting bias, cSCC researchers should consider reporting these core outcomes. Further work needs to be performed to identify the measures that should be reported for each of these outcomes

Bilateral patterns and motor function of the extralaryngeal branching of the recurrent laryngeal nerve

Purpose To evaluate the bilateral patterns and motor function of the extralaryngeal branches (ELB) of the recurrent laryngeal nerve(RLN)