Seismic Vulnerability of the Italian Roadway Bridge Stock

This study focuses on the seismic vulnerability evaluation of the Italian roadway bridge stock, within the framework of a Civil Protection sponsored project. A comprehensive database of existing bridges (17,000 bridges with different level of knowledge) was implemented. At the core of the study stands a procedure for automatically carrying out state-of-the-art analytical evaluation of fragility curves for two performance levels – damage and collapse – on an individual bridge basis. A webGIS was developed to handle data and results. The main outputs are maps of bridge seismic risk (from the fragilities and the hazard maps) at the national level and real-time scenario damage-probability maps (from the fragilities and the scenario shake maps). In the latter case the webGIS also performs network analysis to identify routes to be followed by rescue teams. Consistency of the fragility derivation over the entire bridge stock is regarded as a major advantage of the adopted approach

In-stent restenosis of superficial femoral artery: use all arrows in the quiver.

In-stent restenosis (ISR) is a common superficial femoral artery (SFA) stenting complication, occurring in more than one third of patients within 2-3 years after the index procedure. Moreover, there is no standard treatment for ISR, and although many options are available, there is still limited data regarding its optimal management. We report a paradigmatic case report of a patient complaining of symptomatic peripheral arterial disease, underwent multiple endovascular revascularizations for recurrent femoro-popliteal ISR. A step-by-step approach was followed. At the time of the first presentation, the ISR was treated by drug-eluting balloon (DEB) angioplasty. The repeated ISR was treated by laser debulking, achieving a good angiographic result. Finally, after the third repeated restenosis, a combined approach with laser debulking and DEB angioplasty guaranteed a good acute angiographic result. Long-term duplex-scan follow-up demonstrated the good patency of the femoro-popliteal target lesion

Genetic differentiation between insular and continental populations of migratory and resident warblers, the Great Reed Warbler Acrocephalus arundinaceus and the Cetti's Warbler Cettia cetti Journal of Ornithology

[EN] Island populations are frequently smaller than continental populations, have lower genetic diversity, are more inbred and show genetic differentiation from the mainland ones. However, sufficient numbers of immigrants may reduce the differentiation of insular populations and moderate the effects of genetic drift. In this study, we compared insular and continental populations of Cetti¿s Warbler Cettia cetti and Great Reed Warbler Acrocephalus arundinaceus. We assessed the degree of genetic differentiation between insular and continental birds, their demographic history and genetic diversity. We compared the results, taking into account the differences in migration strategy and morphology of the two warblers. We found slightly lower genetic diversity in the insular populations than in the continental birds, possibly because of the lower population size or reduced immigration. The genetic differentiation between island and mainland birds was low, but higher in Cetti¿s Warbler than in the Great Reed Warbler, suggesting differences in the species¿ capability of crossing the sea. We found evidence for a past bottleneck in both the insular and continental populations of Cetti¿s Warbler, while for the Great Reed Warbler we found no signs of past population reductions. A high dispersal capability of the Great Reed Warbler may have allowed high gene flow, which may explain the observed interspecific differences in the demographic history of the Great Reed Warbler and Cetti¿s Warbler.We acknowledge M. Rebassa, H. Rguibi-Idrissi, M. Marin, J. Gomez, Santi, Luis, Kames and family and many others, who have helped us with the fieldwork. We would also like to thank the authorities of the Marjal de Pego-Oliva Natural Park, the S'Albufera de Mallorca Natural Park, the Consejeria de medio Ambiente y Desarrollo Rural de Castilla-La Mancha, the Servei de Conservacio de la Biodiversitat de la Generalitat Valenciana and the Haut Commissariat aux Eaux et Forets et a la lutte contre la desertification de Rabat, Morocco for providing the facilities to work in protected areas and for the relevant permits. We are grateful to M. Serra and the researchers and Ph.D. students of the Laboratory of Evolutionary Ecology (Institute Cavanilles of Biodiversity and Evolutionary Biology University of Valencia), for providing a laboratory for DNA extraction. This study has been partly financed by projects CGL2005-02041/BOS and CGL201021933-0O2-02 of the Spanish Ministry of Science and Innovation and by the University of Oulu. F. Ceresa was supported by an Atraent talent grant from the University of Valencia.Ceresa, F.; Belda, E.; Kvist, L.; Kajanus, M.; Monrós González, JS. (2018). Genetic differentiation between insular and continental populations of migratory and resident warblers, the Great Reed Warbler Acrocephalus arundinaceus and the Cetti's Warbler Cettia cetti Journal of Ornithology. Journal of Ornithology (Online). 159(3):703-712. https://doi.org/10.1007/s10336-018-1543-2S703712159

Medical-grade silicone coated with rhamnolipid R89 is effective against Staphylococcus spp. Biofilms

Staphylococcus aureus and Staphylococcus epidermidis are considered two of the most important pathogens, and their biofilms frequently cause device-associated infections. Microbial biosurfactants recently emerged as a new generation of anti-adhesive and anti-biofilm agents for coating implantable devices to preserve biocompatibility. In this study, R89 biosurfactant (R89BS) was evaluated as an anti-biofilm coating on medical-grade silicone. R89BS is composed of homologues of the mono- (75%) and di-rhamnolipid (25%) families, as evidenced by mass spectrometry analysis. The antimicrobial activity against Staphylococcus spp. planktonic and sessile cells was evaluated by microdilution and metabolic activity assays. R89BS inhibited S. aureus and S. epidermidis growth with minimal inhibitory concentrations (MIC99) of 0.06 and 0.12 mg/mL, respectively and dispersed their pre-formed biofilms up to 93%. Silicone elastomeric discs (SEDs) coated by R89BS simple adsorption significantly counteracted Staphylococcus spp. biofilm formation, in terms of both built-up biomass (up to 60% inhibition at 72 h) and cell metabolic activity (up to 68% inhibition at 72 h). SEM analysis revealed significant inhibition of the amount of biofilm-covered surface. No cytotoxic effect on eukaryotic cells was detected at concentrations up to 0.2 mg/mL. R89BS-coated SEDs satisfy biocompatibility requirements for leaching products. Results indicate that rhamnolipid coatings are effective anti-biofilm treatments and represent a promising strategy for the prevention of infection associated with implantable devices

Performance of ALICE pixel prototypes in high energy beams

The two innermost layers of the ALICE inner tracking system are instrumented with silicon pixel detectors. Single chip assembly prototypes of the ALICE pixels have been tested in high energy particle beams at the CERN SPS. Detection efficiency and spatial precision have been studied as a function of the threshold and the track incidence angle. The experimental method, data analysis and main results are presented.Comment: 10 pages, 9 figures, contribution to PIX2005 Workshop, Bonn (Germany), 5-8 September 200

Beam Test Performance and Simulation of Prototypes for the ALICE Silicon Pixel Detector

The silicon pixel detector (SPD) of the ALICE experiment in preparation at the Large Hadron Collider (LHC) at CERN is designed to provide the precise vertex reconstruction needed for measuring heavy flavor production in heavy ion collisions at very high energies and high multiplicity. The SPD forms the innermost part of the Inner Tracking System (ITS) which also includes silicon drift and silicon strip detectors. Single assembly prototypes of the ALICE SPD have been tested at the CERN SPS using high energy proton/pion beams in 2002 and 2003. We report on the experimental determination of the spatial precision. We also report on the first combined beam test with prototypes of the other ITS silicon detector technologies at the CERN SPS in November 2004. The issue of SPD simulation is briefly discussed.Comment: 4 pages, 5 figures, prepared for proceedings of 7th International Position Sensitive Detectors Conference, Liverpool, Sept. 200

The Reliability of Anamnestic Data in the Management of Clostridium Tetani Infection in Elderly

Background: Tetanus infection remains a significant complication of wounds. Because most tetanus treatment guidelines rely on anamnestic data collected directly from patients, the congruence between anamnesis and laboratory evidence must be verified, especially in the elderly population. Aim: Assess, in both the geriatric population (>65) and the non-geriatric one, the reliability of anamnestic data for managing patients with tetanus-risk wounds, identified categories of populations most exposed to non-vaccination coverage, and assessed the agreement of the Tetanos Quick Stick (TQS) results with the therapy performed (administration of tetanus vaccine or immunoglobulin). Methods: In this retrospective single-center observational study, patients were asked their immunization status against tetanus vaccination. The decision to administer a vaccine or immunoglobulin was therefore clinical and based on anamnestic criteria. The TQS test was then given to patients who were unaware of their immunity status. Patients who thought they knew it but were not sure were given the TQS test to determine whether the anamnestic collection was supported by the test. The TQS test results were compared with the anamnestic data. Results: Most patients, geriatric and not geriatric, did not know their immune status. Among those who reported knowing their immune status, there was no agreement between the vaccine coverage declared by patients and the TQS test results (p < 0.001), mainly in geriatric patients but also in the control group. Elderly and women had significantly lower positive TQS test results (p < 0.001). There was a statistically significant discrepancy (p < 0.001) between the therapy based on anamnestic data and the TQS test results. Conclusion: The reliability of anamnestic data for the management of patients with tetanus-risk wounds is low and decreases with age, becoming minimal in geriatric patients. Elderly and women are less likely to have an effective vaccination status against tetanus

Trauma coagulopathy and its outcomes

Background and Objectives: Trauma coagulopathy begins at the moment of trauma. This study investigated whether coagulopathy upon arrival in the emergency room (ER) is correlated with increased hemotransfusion requirement, more hemodynamic instability, more severe anatomical damage, a greater need for hospitalization, and hospitalization in the intensive care unit (ICU). We also analyzed whether trauma coagulopathy is correlated with unfavorable indices, such as acidemia, lactate increase, and base excess (BE) increase. Material and Methods: We conducted a prospective, monocentric, observational study of all patients (n = 503) referred to the Department of Emergency and Acceptance, IRCCS Fondazione Policlinico San Matteo, Pavia, for major trauma from 1 January 2018 to 30 January 2019. Results: Of the 503 patients, 204 had trauma coagulopathy (group 1), whereas 299 patients (group 2) did not. Group 1 had a higher hemotransfusion rate than group 2. In group 1, 15% of patients showed hemodynamic instability compared with only 8% of group 2. The shock index (SI) distribution was worse in group 1 than in group 2. Group 1 was more often hypotensive, tachycardic, and with low oxygen saturation, and had a more severe injury severity score than group 2. In addition, 47% of group 1 had three or more body districts involved compared with 23% of group 2. The hospitalization rate was higher in group 1 than in group 2 (76% vs. 58%). The length of hospitalization was >10 days for 45% of group 1 compared with 28% of group 2. The hospitalization rate in the ICU was higher in group 1 than in group 2 (22% vs. 14.8%). The average duration of ICU hospitalization was longer in group 1 than in group 2 (12.5 vs. 9.78 days). Mortality was higher in group 1 than in group 2 (3.92% vs. 0.98%). Group 1 more often had acidemia and high lactates than group 2. Group 1 also more often had BE <−6. Conclusions: Trauma coagulopathy patients, upon arrival in the ER, have greater hemotransfusion (p = 0.016) requirements and need hospitalization (p = 0.032) more frequently than patients without trauma coagulopathy. Trauma coagulopathy seems to be more present in patients with a higher injury severity score (ISS) (p = 0.000) and a greater number of anatomical districts involved (p = 0.000). Head trauma (p = 0.000) and abdominal trauma (p = 0.057) seem related to the development of trauma coagulopathy. Males seem more exposed than females in developing trauma coagulopathy (p = 0.018). Upon arrival in the ER, the presence of tachycardia or alteration of SI and its derivatives can allow early detection of patients with trauma coagulopathy