Optimization of Stone Cutting Techniques for the Seismic Protection of Archaeological Sites

Since the beginning of civilization, history tells of the movement of art pieces, monuments and manufacts from site to site. The causes are multiple: the displacements due to the "spoils of war", ordered by kings and emperors, the movements caused by the need for reuse, especially in the early Christian period, and so forth. Considerations about the events of the past, yield a possible strategy to transform this concept into a technique for earthquake prevention of archaeological sites. The seismic safety retrofits have often proven to be scarcely effective, because of the difficulties involved in complex sites. The aim of this study is to analyze an "alternative" method of preventing natural disaster like floods, eruption and earthquakes, through the movimentation of the most representative structural elements of archaeological sites by decomposition of the masonry and marbles [1]. The procedure considers a process of "cutting optimization," calibrated on the characteristics of the specific material that has to be cut and then displaced in safer places (i.e., MEP, "manufact evacuation plan"). This process should not create excessive problems to the structure, and aims to reassembly the manufact in contexts able to guarantee safety through advanced earthquake-resistant expedients. From these considerations, the work develops a procedure to safeguard the archaeological site of Pompei (Naples), through an appropriate analysis of representative portions of the site, aimed to a careful handling and to a proper reconstruction in a safe location, from the seismic point of vie

Optical coherence tomography angiography in myopic peripapillary intrachoroidal cavitation complicated by choroidal neovascularization

Purpose: To detect the vessel density (VD) of the radial peripapillary capillary (RPC) in eyes affected by pathological myopia with or without a peripapillary intrachoroidal cavitation (PICC) and in eyes with PICC complicated by choroidal neovascularization (CNV), using optical coherence tomography angiography (OCTA). Methods: We prospectively enrolled highly myopic patients from January 2016 to December 2019 at the Eye Clinic of the University of Naples “Federico II.” We divided included patients into three groups: group 1 including patients with PICC complicated by CNV; group 2 including patients with PICC without complications; group 3 including patients with high myopia without PICC and CNV. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc analysis was used to evaluate differences in VD of radial peripapillary capillary (RPC) in papillary whole, peripapillary regions and its sectors among the three groups. Results: We enrolled 12 highly myopic eyes with PICC complicated by CNV, 21 highly myopic eyes with PICC without CNV and 23 highly myopic eyes without PICC. The myopic eyes with PICC revealed a statistically significant reduction in VD of the RPC comparing to the other groups (p < 0.001), especially in eyes affected by myopic PICC complicated by CNV (p < 0.001). These results were similar analyzing the VD in different sectors of the peripapillary region among the three groups (p < 0.001). Conclusion: OCTA detects the changes in peripapillary vascular density of highly myopic eyes. We demonstrated that the RPC vasculature is significantly influenced by the presence of PICC, especially in myopic eyes developing a CNV

Optical coherence tomography angiography in Tuberous sclerosis complicated with macular choroidal neovascularization

This study describe the optical coherence tomography angiography (OCTA) features of a young patient with Tuberous sclerosis complicated with CNV unilateral macular choroidal neovascularization during the ranibizumab therapy. OCTA scans of macular region of right eye, revealed a dense microvascular network confirming the diagnosis of CNV. After four monthly intravitreal injections, OCTA revealed a decrease of size and activity of CNV. OCTA is a valid, non-invasive, dyeless, and reliable method that could improve the diagnosis and management of CNV in child with Tuberous sclerosis

Seismic assessment and rehabilitation of a historical theatre based on a macro-element strategy

The structural and seismic assessment of the 19th-century Petruzzelli theater in Bari (Italy) is presented. The macro-elements strategy was adopted to dismantle the whole structure in parts. The steel dome was verified through dynamic multi-modal analysis based on finite element model. Each masonry macro-element was firstly verified through a kinematic analysis aiming at excluding local collapse mechanisms. Afterwards, a nonlinear static analysis was carried out in order to evaluate its overall seismic capacity. The effectiveness of linear or nonlinear analyses and of the macro-element strategy compared with other modeling techniques is also discussed. After highlighting the structural deficiencies of the theater, upgrading solutions are proposed with consideration of the safety needs and the architectural preservation requirements based on the historical importance of the buildin

Cannulation of Obscured Papilla Aided By Using a Balloon to Flatten Out Duodenal Folds, in a Patient with Acute Pancreatitis

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Interdisciplinary and International Workshop as Technological Design Method Focused on the European Ods Strategy

The innovative rules of the Europe 2020 Strategy, which follow the Lisbon Strategy (2000) and the Copenhagen Declaration (2002), promote smart and sustainable growth through the promotion of lowpollutant, resource-efficient and effective project strategies for improving human, social and environmental conditions. This paper illustrates the workshop design experience conducted in collaboration between the Escuela Superior de Edificacion (ETSEM) of the Universidad Politecnica de Madrid, the Department of Civil, Building and Environmental Engineering (DICEA) of Università di Napoli "Federico II" and the Department of Architecture and Industrial Design (DADI) of Università della Campania "L. Vanvitelli", focusing on the added value for the three research groups to integrate different teaching methods according that strategies

Efficacy of Three Different Prophylactic Treatments for Postoperative Nausea and Vomiting after Vitrectomy: A Randomized Clinical Trial

Postoperative nausea and vomiting (PONV) after vitreoretinal surgery may potentially be associated with severe complications, such as suprachoroidal hemorrhage. The purpose of the present multicenter clinical trial (NCT02386059) was to assess the efficacy of three different prophylactic treatments for PONV after vitrectomy under local anesthesia. Patients undergoing primary vitrectomy were randomized to the control arm or to one of the treatment arms (4 mg ondansetron, 4 mg dexamethasone, combination of the two drugs). The primary outcome measure was the proportion of complete response (no nausea, no vomiting, no retching, and no use of antiemetic rescue medication) during 24 h after vitrectomy. Secondary outcomes included the severity standardized score of PONV, postoperative pain standardized score, and rate of ocular and non-ocular adverse events. Baseline demographics of the 1287 patients were comparable between the four arms. The combined therapy group showed a statistically significant lower incidence of PONV compared to the placebo and monotherapy (p &lt; 0.001). PONV severity was also reduced in the combination group compared to the others (p &lt; 0.001). Postoperative pain scores and adverse events were comparable among the four groups. Combined therapy with dexamethasone and ondansetron was the most effective treatment for reducing the incidence and severity of PONV in patients undergoing vitrectomy under local anesthesia

Externalities and complementarities in platforms and ecosystems: From structural solutions to endogenous failures

Platforms and ecosystems provide structures for constellations of economic actors to engage and interact as they seek to create and capture value. We consider how the constructs of platforms and ecosystems relate and explore why they have become more ubiquitous by focusing on the nature of their value-add. We propose that they emerge as a response to distinct market failures, which we identify, and we explain which specific externalities they help overcome. We also identify post-hoc endogenous functional and distributional failures that platforms and ecosystems, in turn, generate. We discuss implications for theory and practice

Impact of the COVID-19 Pandemic on Corneal Transplantation: A Report From the Italian Association of Eye Banks

Purpose: To analyze the impact of COVID-19 on Italian corneal transplantation from March-2020 to February 2021 compared to the same timeframe of the 2 previous years, in order to identify potential consequences of a global pandemic on corneal procurement and transplantation services during this time. Methods: This national, multicentric, retrospective cohort study evaluated data collected from 12 (100%) Italian eye banks from March 2020 to February 2021 (Group A). The number of tissues collected, distributed and discarded were compared with the same time-frame of the 2 previous years: 2019 and 2018 (group B and C, respectively). The different type of transplants performed were reported. Data were analyzed using a non-parametric Friedman test. Results: Corneal procurement and the percentage of distributed tissues reduced in 2020 by more than 30 and 15%, respectively, compared to the 2 previous years. During the pandemic corneal transplant surgery showed only a modest drop: the number of the penetrating keratoplasties (PKs) and the anterior lamellar keratoplasties (ALKs) decreased by about 30 and 20% in comparison with groups B and C, respectively; between the Endothelial Keratoplasties (EKs), the Descemet membrane endothelial keratoplasty (DMEK) increased slightly from March 2020 to February 2021. Conclusions: Italy was one of the first countries most affected by the outbreak of COVID-19, and the Italian government adopted severe measures to limit viral transmission. The pandemic generated several implications in corneal transplant activity during the first lockdown. Then an efficacious reaction with constant, vigorous work led to a resumption of transplant surgery to a near-normal standard. The increase of EKs, despite the pandemic, is a sign that the advance in corneal transplantation has gone ahead and it continues to evolve

Surface-enhanced Raman spectroscopy of tears: Toward a diagnostic tool for neurodegenerative disease identification

Significance: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was proposed as a support for diagnosing neurodegenerative pathologies, including different forms of dementia and Alzheimer's disease (AD). In this field, timely and reliable discrimination and diagnosis are critical aspects for choosing a valid medical therapy, and new methods are highly required. Aim: The aim is to evince spectral differences in SERS response of human tears from AD affected, mild cognitive impaired (MCI), and healthy control (Ctr) subjects. Approach: Human tears were characterized by SERS coupled with multivariate data analysis. Thirty-one informed subjects (Ctr, MCI, and AD) were considered. Results: Average SERS spectra from Ctr, MCI, and AD subjects evidenced differences related to lactoferrin and lysozyme protein components. Quantitative changes were also observed by determining the intensity ratio between selected bands. We also constructed a classification model that discriminated among AD, MCI, and Ctr subjects. The model was built using the scores obtained by performing principal component analysis on specific spectral regions (i-PCA). Conclusions: The results are very encouraging with interesting perspectives for medical applications as support of clinical diagnosis and discrimination of AD from other forms of dementia