1,180 research outputs found
Traumatic vertebral artery dissection presenting with incomplete congruous homonymous quadrantanopia
Accumulation of heavy metals in food web components across a gradient of lakes
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109770/1/lno20004571525.pd
Methylmercury in marine ecosystems : spatial patterns and processes of production, bioaccumulation, and biomagnification
Author Posting. © International Association for Ecology and Health, 2008. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in EcoHealth 5 (2008): 399-408, doi:10.1007/s10393-008-0201-1.The spatial variation of MeHg production, bioaccumulation and biomagnification in marine food
webs is poorly characterized but critical to understanding the links between sources and higher
trophic levels such as fish that are ultimately vectors of human and wildlife exposure. This paper
discusses both large and local scale processes controlling Hg supply, methylation,
bioaccumulation and transfer in marine ecosystems. While global estimates of Hg supply suggest
important open ocean reservoirs of MeHg, only coastal processes and food webs are known
sources of MeHg production, bioaccumulation, and bioadvection. The patterns observed to date
suggest that not all sources and biotic receptors are spatially linked and that physical and
ecological processes are important in transferring MeHg from source regions to bioaccumulation
in marine food webs and from lower to higher trophic levels.Supported by NIH Grant
Number P42 ESO7373 from the NIEHS, SERDP funds from the Department of Defense, the
ESSRF (Environmental Science Strategic Research Fund) DFO, Canada, Woods Hole Sea Grant,
Woods Hole Coastal Ocean Institute, National Science Foundation, and RI-INBRE Grant #P20RR016457 from NCRR, NIH
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Meeting Report: Methylmercury in Marine EcosystemsâFrom Sources to Seafood Consumers
Mercury and other contaminants in coastal and open-ocean ecosystems are an issue of great concern globally and in the United States, where consumption of marine fish and shellfish is a major route of human exposure to methylmercury (MeHg). A recent National Institute of Environmental Health SciencesâSuperfund Basic Research Program workshop titled âFate and Bioavailability of Mercury in Aquatic Ecosystems and Effects on Human Exposure,â convened by the Dartmouth Toxic Metals Research Program on 15â16 November 2006 in Durham, New Hampshire, brought together human health experts, marine scientists, and ecotoxicologists to encourage cross-disciplinary discussion between ecosystem and human health scientists and to articulate research and monitoring priorities to better understand how marine food webs have become contaminated with MeHg. Although human health effects of Hg contamination were a major theme, the workshop also explored effects on marine biota. The workgroup focused on three major topics: a) the biogeochemical cycling of Hg in marine ecosystems, b) the trophic transfer and bioaccumulation of MeHg in marine food webs, and c) human exposure to Hg from marine fish and shellfish consumption. The group concluded that current understanding of Hg in marine ecosystems across a range of habitats, chemical conditions, and ocean basins is severely data limited. An integrated research and monitoring program is needed to link the processes and mechanisms of MeHg production, bioaccumulation, and transfer with MeHg exposure in humans
Sources to Seafood: Mercury Pollution in the Marine Environment
In 2010, the Toxic Metals Superfund Research Program at Dartmouth College brought together a group of 50 scientists and policy stakeholders to form C-MERC, the Coastal and Marine Mercury Ecosystem Research Collaborative. The goal was to review current knowledgeâand knowledge gapsârelating to a global environmental health problem, mercury contamination of the worldâs marine fish. C-MERC participants attended two workshops over a two-year period, and in 2012 C-MERC authors published a series of peer-reviewed papers in the journals Environmental Health Perspectives and Environmental Research that elucidated key processes related to the inputs, cycling, and uptake of mercury in marine ecosystems, effects on human health, and policy implications. This report synthesizes the knowledge from these papers in an effort to summarize the science relevant to policies being considered at regional, national, and global levels.
The Dartmouth Toxic Metals Superfund Research Program uses an interdisciplinary approach to investigate the ways that arsenic and mercury in the environment affect ecosystems and human health. Arsenic and mercury are commonly found in Superfund sites around the U.S. as well as other areas that result in exposures to certain communities. The Research Translation Core of the program communicates program science to government partners, non-governmental organizations, health care providers and associations, universities and the lay community, and facilitates the use of its research for the protection of public health. The Research Translation Core organized the C-MERC effort.
The Superfund Research Program of the National Institute of Environmental Health Sciences supports a network of university programs that investigate the complex health and environmental issues associated with contaminants found at the nationâs hazardous waste sites. The Program coordinates with the Environmental Protection Agency and the Agency for Toxic Substances and Disease Registry of the Centers for Disease Control and Prevention, federal entities charged with management of environmental and human health hazards associated with toxic substances
Patients' knowledge and perception on optic neuritis management before and after an information session
<p>Abstract</p> <p>Background</p> <p>Patients' understanding of their condition affect the choice of treatment. The aim of this study is to evaluate patients' understanding and treatment preferences before and after an information session on the treatment of acute optic neuritis.</p> <p>Methods</p> <p>Participants were asked to complete a questionnaire consisting of 14 questions before and after an information session presented by a neuro-ophthalmologist. The information session highlighted the treatment options and the treatment effects based on the Optic Neuritis Treatment Trial in plain patient language. The information session stressed the finding that high dose intravenous steroid therapy accelerated visual recovery but does not change final vision and that treatment with oral prednisone alone resulted in a higher incidence of recurrent optic neuritis.</p> <p>Results</p> <p>Before the information session, 23 (85%) participants knew that there was treatment available for ON and this increased to 27 (100%) after the information session. There were no significantly change in patients knowledge of symptoms of ON and purpose of treatment before and after the information session. Before the information session, 4 (14%) respondents reported they would like to be treated by oral steroid alone in the event of an optic neuritis and 5 (19%) did not respond. After the education session, only 1 patient (4%) indicated they would undergo treatment with oral steroid alone but 25 (92%) indicated they would undergo treatment with intravenous steroid treatment, alone or in combination with oral treatment. Results indicated that there were significant differences in the numbers of participants selecting that they would undergo treatment with a steroid injection (n = 22, p = 0.016).</p> <p>Conclusions</p> <p>In this study, patients have shown good understanding of the symptoms and signs of optic neuritis. The finding that significant increases in the likelihood of patients engaging in best practice can be achieved with an information session is very important. This suggests that patient knowledge of available treatments and outcomes can play an important role in implementing and adopting guideline recommendations.</p
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