Solar cooling: a case study

Throughout the years various methods for heat prevention and indoor temperatures control in the summer have been used. The alternative cooling strategies are based on various passive and low energy cooling technologies for protection of the buildings via design measures or special components to moderate the thermal gains, or to reject the excess heat to the ambient environment. All these techniques aim to reduce summer cooling loads and electricity demand for air conditioning. During the summer the demand for electricity increases because of the extensive use of heating ventilation air conditioning (HVAC) systems, which increase the peak electric load, causing major problems in the electric supply. The energy shortage is worse during ‘dry’ years because of the inability of the hydroelectric power stations to function and cover part of the peak load. The use of solar energy to drive cooling cycles for space conditioning of most buildings is an attractive concept, since the cooling load coincides generally with solar energy availability and therefore cooling requirements of a building are roughly in phase with the solar incidence. Solar cooling systems have the advantage of using absolutely harmless working fluids such as water, or solutions of certain salts. They are energy efficient and environmentally safe. The purpose of this paper is to describe a Solar Cooling System to be installed on the roof of a building in Rome, the headquarters of the State Monopoly. The medium size power plant is composed of the following components: − Solar Collectors; − Thermal Storage Tank; − Absorption Chiller; The plant design is based on a dynamic simulation in TRNSYS, a dynamic simulation tool used by engineers all over the world to make energy calculations in a transient state

Bioclimatic design, assisted by numerical simulation in a transient state

The bioclimatic design aims to realize designing, localizative technological, plant-engineering choices, in order to have a housing model that satisfies comfort requisites through microclimate passive control and the control of the energy for heating plants. The study in this field is booming and, thanks to fast and effective calculation systems, the researchers can achieve reliable outcomes in reasonable times. Starting by a good thermal-energetic design and a bit of intuition, the bioclimatic design issue has been tackled scientifically and sistematically. So, we reached spe-cific and general conclusions useful to quantify and select the most used technics in this field. Our work doesn’t aim at a strict demonstration but at a study through which verify, understand and in-crease the knowledge of thermal-energetic phenomenon of building-environmental interaction. Many of the simulations in transient state have been made on matters we considered the most influential on the global behaviours of residential buildings. The matters on which we focused are: thermal cover (ther-mal insulation and inertia), glazed surfaces, screenings (static and mobile), in direct geothermal energy, vent (natural and artificial, diurnal and nocturnal). All this work has the aim to create the right balance between naatural cooling and heating during a while year, in order to guarantee thermal comfort to residents, thereby decreasing to a minimum the use of plants during the summer and the winter. The consequent designing-technical choices come from scrupulous interpretation of the outcomes, achieved by extrapolating from generic treatment the compatibility with the climatic conditions. In this per-spective, the authors, with the research, are using their knowledges to get innovative outcomes and integrate the research with empirical matters. residential buildings. The matters on which we focused are: thermal cover (ther-mal insulation and inertia), glazed surfaces, screenings (static and mobile), in direct geothermal energy, vent (natural and artificial, diurnal and nocturnal). All this work has the aim to create the right balance between naatural cooling and heating during a while year, in order to guarantee thermal comfort to residents, thereby decreasing to a minimum the use of plants during the summer and the winter. The consequent designing-technical choices come from scrupulous interpretation of the outcomes, achieved by extrapolating from generic treatment the compatibility with the climatic conditions. In this per-spective, the authors, with the research, are using their knowledges to get innovative outcomes and integrate the research with empirical matters

A systematic comparison of protocols for recovery of high-quality rna from human islets extracted by laser capture microdissection

The isolation of high-quality RNA from endocrine pancreas sections represents a consider-able challenge largely due to the high ribonuclease levels. Laser capture microdissection (LCM) of mammalian islets, in association with RNA extraction protocols, has emerged as a feasible approach to characterizing their genetic and proteomic profiles. However, a validated protocol to obtain high-quality RNA from LCM-derived human pancreas specimens that is appropriate for next-generation sequencing analysis is still lacking. In this study, we applied four methods (Picopure extraction kit, Qiazol protocol, Qiazol + Clean-up kit, and RNeasy Microkit + Carrier) to extract RNA from human islets obtained from both non-diabetic individuals and patients with type 2 diabetes who had undergone partial pancreatectomy, as well as handpicked islets from both non-diabetic and diabetic organ donors. The yield and purity of total RNA were determined by 260/280 absorbance using Nanodrop 100 and the RNA integrity number with a bioanalyzer. The results indicated that among the four methods, the RNeasy MicroKit + Carrier (Qiagen) provides the highest yield and purity

COMPARATIVE ANALYSIS OF TECHNICAL, ECONOMICAL AND ENVIRONMENTAL FEASIBILITY OF COGENERATION PLANT USING WOOD BIOMASS

After having identified, in a previous work [6], the possible sites for the location of a new cogeneration plant using wood biomass in the Mountain Community of Carnia, Friuli Venezia Giulia Region (Italy), the technical and economic feasibility and environmental sustainability of such a system has been carried out in order to evaluate the feasibility of the proposed solution

COMPARATIVE ANALYSIS OF TECHNICAL, ECONOMICAL AND ENVIRONMENTAL FEASIBILITY OF COGENERATION PLANT USING WOOD BIOMASS

After having identified, in a previous work [6], the possible sites for the location of a new cogeneration plant using wood biomass in the Mountain Community of Carnia, Friuli Venezia Giulia Region (Italy), the technical and economic feasibility and environmental sustainability of such a system has been carried out in order to evaluate the feasibility of the proposed solution

Sotagliflozin, the first dual SGLT inhibitor. Current outlook and perspectives

Sotagliflozin is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D). Sotagliflozin inhibits renal sodium-glucose co-transporter 2 (determining significant excretion of glucose in the urine, in the same way as other, already available SGLT-2 selective inhibitors) and intestinal SGLT-1, delaying glucose absorption and therefore reducing post prandial glucose. Well-designed clinical trials, have shown that sotagliflozin (as monotherapy or add-on therapy to other anti-hyperglycemic agents) improves glycated hemoglobin in adults with T2D, with beneficial effects on bodyweight and blood pressure. Similar results have been obtained in adults with T1D treated with either continuous subcutaneous insulin infusion or multiple daily insulin injections, even after insulin optimization. A still ongoing phase 3 study is currently evaluating the effect of sotagliflozin on cardiovascular outcomes (ClinicalTrials.gov NCT03315143). In this review we illustrate the advantages and disadvantages of dual SGLT 2/1 inhibition, in order to better characterize and investigate its mechanisms of action and potentialities

Effect of Vitamin D Supplementation on Obesity-Induced Insulin Resistance: A Double-Blind, Randomized, Placebo-Controlled Trial

Objective: The aim was to investigate whether vitamin D supplementation, combined with a hypocaloric diet, could have an independent effect on insulin sensitivity in subjects with both overweight and hypovitaminosis D. Changes from baseline in anthropometric parameters, body composition, glucose tolerance, and insulin secretion were considered as secondary outcomes. Methods: Eighteen volunteers who were nondiabetic and vitamin D deficient and had BMI > 25 kg/m2 were randomized (1:1) in a double-blind manner to a hypocaloric diet + either oral cholecalciferol at 25,000 IU/wk or placebo for 3 months. Hyperinsulinemic-euglycemic clamp to measure insulin sensitivity was performed at baseline and after intervention. Results: Body weight in both groups decreased significantly (−7.5% in the vitamin D group and −10% in the placebo group; P < 0.05 for both), with no between-group differences. Serum 25-hydroxyvitamin D levels in the vitamin D group increased considerably (from 36.7 ± 13.2 nmol/L to 74.8 ± 18.7 nmol/L; P < 0.001). Insulin sensitivity in the vitamin D group improved (from 4.6 ± 2.0 to 6.9 ± 3.3 mg·kg−1·min−1; P < 0.001), whereas no changes were observed in the placebo group (from 4.9 ± 1.1 to 5.1 ± 0.3 mg·kg−1·min−1; P = 0.84). Conclusions: Cholecalciferol supplementation, combined with a weight loss program, significantly improves insulin sensitivity in healthy subjects with obesity and might represent a personalized approach for insulin-resistant subjects with obesity

Increased Beta Cell Workload Modulates Proinsulin/Insulin Ratio in Humans

Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing, or be secondary to increased demand on \u3b2-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between relative hyperproinsulinemia and increased secretory demand is to study the dynamic changes in proinsulin to insulin ratio after partial pancreatectomy, a model of acute increased beta cell workload on the remaining pancreas. To pursue this aim, non-diabetic patients, scheduled for partial pancreatectomy, underwent 4-hour mixed meal tests and hyperinsulinemic euglycemic clamps before and after surgery. Following acute beta cell mass reduction, no changes were observed in fasting proinsulin to insulin ratio, while fold change in proinsulin to insulin ratio significantly increased over time after the meal. Further, our data demonstrate that whole-body insulin resistance is associated with underlying defects in proinsulin secretion, which become detectable only in the presence of increased insulin secretion demand

Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes

BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of β cell mass. There is a long-standing debate as to the relative contribution of these factors to clinically manifesting β cell dysfunction. The aim of this study was to verify the acute effect of one of these factors, the reduction of β cell mass, on the subsequent development of hyperglycemia. METHODS. To pursue this aim, nondiabetic patients, scheduled for identical pancreaticoduodenectomy surgery, underwent oral glucose tolerance tests (OGTT) and hyperglycemic clamp (HC) procedures, followed by arginine stimulation before and after surgery. Based on postsurgery OGTT, subjects were divided into 3 groups depending on glucose tolerance: normal glucose tolerance (post-NGT), impaired glucose tolerance (post-IGT), or having diabetes mellitus (post-DM). RESULTS. At baseline, the 3 groups showed similar fasting glucose and insulin levels; however, examining the various parameters, we found that reduced first-phase insulin secretion, reduced glucose sensitivity, and rate sensitivity were predictors of eventual postsurgery development of IGT and diabetes. CONCLUSION. Despite comparable functional mass and fasting glucose and insulin levels at baseline and the very same 50% mass reduction, only reduced first-phase insulin secretion and glucose sensitivity predicted the appearance of hyperglycemia. These functional alterations could be pivotal to the pathogenesis of type 2 diabetes (T2DM)