Maximal Information Coefficient Analysis

Abstract In the domain of the Side Channel Attacks, various statistical tools have succeeded to retrieve a secret key, as the Pearson coefficient or the Mutual Information. In this paper we propose to study the Maximal Information Coefficient (MIC) which is a non-parametric method introduced by Reshef et al. [13] to compare two random variables. The MIC is based on the mutual information but it is easier to implement and is robust to the noise. We show how apply this tool in the particular case of the side channel attacks. As in statistics, benefits only appears with drawbacks, the computing complexity of the MIC is high. Therefore, we propose a way to efficiently compute the MIC. The obtained attack called the Maximal Information Coefficient Analysis is compared to the CPA [3] and the MIA [8]. The results show the interest of this approach when the leakage is noisy and bad modeleled

Study of Deep Learning Techniques for Side-Channel Analysis and Introduction to ASCAD Database

To provide insurance on the resistance of a system against side-channel analysis, several national or private schemes are today promoting an evaluation strategy, common in classical cryptography, which is focussing on the most powerful adversary who may train to learn about the dependency between the device behaviour and the sensitive data values. Several works have shown that this kind of analysis, known as Template Attacks in the side-channel domain, can be rephrased as a classical Machine Learning classification problem with learning phase. Following the current trend in the latter area, recent works have demonstrated that deep learning algorithms were very efficient to conduct security evaluations of embedded systems and had many advantage compared to the other methods. Unfortunately, their hyper-parametrization has often been kept secret by the authors who only discussed on the main design principles and on the attack efficiencies. This is clearly an important limitation of previous works since (1) the latter parametrization is known to be a challenging question in Machine Learning and (2) it does not allow for the reproducibility of the presented results. This paper aims to address theses limitations in several ways. First, completing recent works, we propose a comprehensive study of deep learning algorithms when applied in the context of side-channel analysis and we clarify the links with the classical template attacks. Secondly, we address the question of the choice of the hyper-parameters for the class of multi-layer perceptron networks and convolutional neural networks. Several benchmarks and rationales are given in the context of the analysis of a masked implementation of the AES algorithm. To enable perfect reproducibility of our tests, this work also introduces an open platform including all the sources of the target implementation together with the campaign of electro-magnetic measurements exploited in our benchmarks. This open database, named ASCAD, has been specified to serve as a common basis for further works on this subject. Our work confirms the conclusions made by Cagli et al. at CHES 2017 about the high potential of convolutional neural networks. Interestingly, it shows that the approach followed to design the algorithm VGG-16 used for image recognition seems also to be sound when it comes to fix an architecture for side-channel analysis

Transcriptome of Aphanomyces euteiches: New Oomycete Putative Pathogenicity Factors and Metabolic Pathways

Aphanomyces euteiches is an oomycete pathogen that causes seedling blight and root rot of legumes, such as alfalfa and pea. The genus Aphanomyces is phylogenically distinct from well-studied oomycetes such as Phytophthora sp., and contains species pathogenic on plants and aquatic animals. To provide the first foray into gene diversity of A. euteiches, two cDNA libraries were constructed using mRNA extracted from mycelium grown in an artificial liquid medium or in contact to plant roots. A unigene set of 7,977 sequences was obtained from 18,864 high-quality expressed sequenced tags (ESTs) and characterized for potential functions. Comparisons with oomycete proteomes revealed major differences between the gene content of A. euteiches and those of Phytophthora species, leading to the identification of biosynthetic pathways absent in Phytophthora, of new putative pathogenicity genes and of expansion of gene families encoding extracellular proteins, notably different classes of proteases. Among the genes specific of A. euteiches are members of a new family of extracellular proteins putatively involved in adhesion, containing up to four protein domains similar to fungal cellulose binding domains. Comparison of A. euteiches sequences with proteomes of fully sequenced eukaryotic pathogens, including fungi, apicomplexa and trypanosomatids, allowed the identification of A. euteiches genes with close orthologs in these microorganisms but absent in other oomycetes sequenced so far, notably transporters and non-ribosomal peptide synthetases, and suggests the presence of a defense mechanism against oxidative stress which was initially characterized in the pathogenic trypanosomatids

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Using the Joint Distributions of a Cryptographic Function in Side Channel Analysis

The Side Channel Analysis is now a classic way to retrieve a secret key in the smart-card world. Unfortunately, most of the ensuing attacks require the plaintext or the ciphertext used by the embedded algorithm. In this article, we present a new method for exploiting the leakage of a device without this constraint. Our attack is based on a study of the leakage distribution of internal data of a cryptographic function and can be performed not only at the beginning or the end of the algorithm, but also at every instant that involves the secret key. This paper focuses on the distribution study and the resulting attack. We also propose a way to proceed in a noisy context using smart distances. We validate our proposition by practical results on an AES128 software implemented on a ATMega2561 and on the DPA contest v4