The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Objective: To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice.Study design The sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 +/- 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity. Results: In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipoprotein-cholesterol (beta = -5.797 [-11.500 to -0.093]), femoral IMT (beta = 0.062 [0.008-0.116]), and the sum of femoral and carotid IMT (beta = 1.107 [0.223-1.919]), but only in the group without sports participation. Slopes of the crude linear regression were greater in the group without sports participation for femoral IMT (t = 2.621; P = .009) and the sum of femoral and carotid IMT (t = 2.876; P = .004) when compared with the group with sports participation. Conclusion: Independent of body fatness and biological maturation, inflammatory status was related to artery IMT and dyslipidemia in prepubertal adolescents, modulated by sport participation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Sports practice is related to parasympathetic activity in adolescents

AbstractObjectiveTo analyze the relationship among sports practice, physical education class, habitual physical activity and cardiovascular risk in adolescents.MethodsCross-sectional study with 120 schoolchildren (mean: 11.7±0.7 years old), with no regular use of medicines. Sports practice and physical education classes were assessed through face-to-face interview, while habitual physical activity was assessed by pedometers. Bodyweight, height and height-cephalic trunk were used to estimate maturation. The following variables were measured: body fatness, blood pressure, resting heart rate, blood flow velocity, intima-media thickness (carotid and femoral) and heart rate variability (mean between consecutive heartbeats and statistical index in the time domain that show the autonomic parasympathetic nervous system activity root-mean by the square of differences between adjacent normal R-R intervals in a time interval). Statistical treatment used Spearman correlation adjusted by sex, ethnicity, age, body fatness and maturation.ResultsIndependently of potential confounders, sports practice was positively related to autonomic parasympathetic nervous system activity (β=0.039 [0.01; 0.76]). On the other hand, the relationship between sport practice and mean between consecutive heartbeats (β=0,031 [–0.01; 0.07]) was significantly mediated by biological maturation.ConclusionsSport practice was related to higher heart rate variability at rest

Efeito dos hábitos comportamentais e gordura corporal sobre indicadores de risco cardiovasculares entre adolescentes: estudo de coorte de 12 meses

Objectives To analyze, after 12 months, (i) the alterations in the behavioral habits and body fat under some indicators of the cardiovascular risk among adolescents, as well, (ii) if these effects of the behavioral habits and body fat were independents. In addition, from cross-sectional data were analyzed to (i) the relationship between physical activity indicators on some cardiovascular risk outcomes; (ii) the relationship between the frequency of breakfast consumption on cardiovascular risk factors, inflammatory and metabolic markers; (iii) the relationship between parasympathetic indices and resting heart rate with cardiovascular risk markers, and (iv) the relationship between hsCRP and lipid profile, blood flow and blood intima-media thickness between prepubertal adolescents were stratified according to the engagement sports practices.Methods Cohort study of 12 months, carried out in Presidente Prudente city, State of Sao Paulo. The inclusion criteria were: (i) age between 11 and 14 years old; (ii) enrolled in the school unit of elementary education; (iii) absence of any known disease; (iv) without drug consumption. All adolescents participated in each measure: (i) behavioral habits; (ii) body fat; (iii) blood pressure; (iv) heart rate resting; (v) heart rate variability; (vi) intima-media thickness; (vii) anthropometry; (viii) lipid profile; (ix) high sensitivity C reactive protein; (x) eating habits; (xi) blood flow and (xii) biological maturation. The relationship among variables were tested by correlation, and, when necessary, it were made some adjustments. Significant relationships were inserted in the multivariate model (linear regression). Teste t Student and variance analysis (ANOVA one way) established comparison among mean values. Significance statistical (p-valor) lower than 5% were considered statically different. All analyses were performed in the software BioEstat (version 5.0, Tefé, Amazonas). Results In all, 120...Objetivos Analisar, após 12 meses de seguimento, (i) se modificações nos hábitos comportamentais e gordura corporal afetam alguns indicadores de risco cardiovasculares entre adolescentes, bem como, (ii) se estes possíveis efeitos dos hábitos comportamentais e gordura corporal foram independentes entre si. Além disso, a partir de informações transversais foram analisadas a (i) relação entre os indicadores de atividades físicas sobre alguns desfechos cardiovasculares de risco a saúde; (ii) relacionamento entre a frequência do consumo do café da manhã sobre os fatores de risco cardiovasculares, inflamatório e metabólicos; (iii) relacionamento entre índices parassimpáticos e frequência cardíaca de repouso com os marcadores de risco cardiovasculares e, (iv) relacionamento entre PCRus e o perfil lipídico, fluxo sanguíneo e EMI arterial entre adolescentes pré-puberes que foram estratificados de acordo com o engajamento de práticas esportivas. Métodos Estudo de coorte de 12 meses, realizada em Presidente Prudente/SP. Os critérios de inclusão foram: i) idade entre 11 e 14 anos; ii) estar regularmente matriculado e frequentando a unidade escolar de ensino básico; iii) não apresentar nenhum distúrbio clínico ou metabólico conhecido que impeça ou influencie na prática habitual de atividades físicas; iv) não fazer consumo eventual ou regular de medicamento que afete o controle da pressão arterial. Todos os voluntários participaram das seguintes avaliações: (i) indicadores de atividade física; (ii) gordura corporal; (iii) pressão arterial; (iv) frequência cardíaca de repouso; (v) variabilidade da frequência cardíaca; (vi) espessura médio-intimal; (vii) antropometria; (viii) perfil lipídico; (ix) proteína C reativa ultrassensível; (x) hábitos alimentares; (xi) fluxo sanguíneo e (xii) maturação biológica. O relacionamento entre as variáveis foi testado pela correlação, sendo necessário, com subsequentes...Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Sports participation improves metabolic profile in adolescents: ABCD growth study

To analyze the impact of participation in sports with different cardiorespiratory fitness (CRF) demands on changes in metabolic and cardiovascular markers in adolescents. Longitudinal study with 12 months of follow-up (Analysis of Behaviors of Children During Growth [ABCD Growth Study]). Overall, 184 adolescents (age 15.6 ± 2.1) were classified according to sports participation: non-sport (control), low CRF sports, and high CRF sports. Metabolic outcomes were total cholesterol (TC) and its fractions, triacylglycerol (TG), glucose, insulin levels, and the insulin resistance index. Cardiovascular outcomes were arterial thickness (carotid and femoral [ultrasound]), blood pressure, and resting heart rate. Adolescents engaged in sports classified as high CRF demand presented a significant increase in HDL-c (1.2 mg/dL [95%CI: −0.5 to 3.0]) when compared to the non-sport group (−2.4 mg/dL [95%CI: −4.4 to −0.5]). Regular engagement in high CRF sports was significantly related to changes in TC (β = −0.027 [95%CI: −0.048 to −0.005]), HDL-c (β = 0.009 [95%CI: 0.001 to 0.019]), LDL-c (β = −0.032 [95%CI: −0.049 to −0.016]), and glucose (β = −0.017 [95%CI: −0.025 to −0.008]), while engagement in low CRF sports was related to changes in TG (β = −0.065 [95%CI: −0.112 to −0.019]). No significant relationships for cardiovascular parameters were observed in the low CRF group, but one significant relationship was found between high CRF sports and changes in SBP (β = −0.063 [95%CI: −0.117 to −0.009]). In conclusion, engagement in sports seems to be beneficial for improvements in metabolic and cardiovascular parameters in adolescents, mainly sports with higher CRF demand

Sport-based physical activity recommendations and modifications in C-reactive protein and arterial thickness

We analyzed the effects of 1 year of engagement in >= 300 min/week of organized sports on inflammatory levels and vascular structure in adolescents. The sample was composed of 89 adolescents (11.6 +/- 0.7 years old [43 boys and 46 girls]), stratified according to engagement in >= 300 min/week of sport practice during at least 12 months of follow-up (n = 15, sport practicen = 74, non-sport practice). Arterial thickness (carotid and femoral) was assessed by ultrasound scan, while high sensitive C-reactive protein levels were used to assess inflammatory status. Trunk fatness (densitometry scanner), biological maturation (age at peak height velocity), blood pressure, and skipping breakfast were treated as covariates. Independently of body fatness and biological maturation, the group engaged in sports presented a higher reduction in C-reactive protein (mean difference -1.559 mg/L [95%CI -2.539 to -0.579]) than the non-sport group (mean difference -0.414 mg/L [95%CI -0.846 to 0.017]) (p = 0.040). There was a significant relationship between changes in C-reactive protein and changes in femoral intima-media thickness in the non-sport group (r = 0.311 [95%CI 0.026 to 0.549]). Conclusion: Inflammation decreased in adolescents engaged in organized sports, independently of trunk fatness and biological maturation. Moreover, inflammation was related to arterial thickening only in adolescents not engaged in sports. What is Known: Intima media thickness is a relevant marker of cardiovascular disease in pediatric groups, being affected by obesity and inflammation. The importance of monitoring inflammatory markers from childhood is enhanced by the fact that alterations in these inflammatory markers in early life predict inflammation and alterations in carotid IMT in adulthood. What is New: Anti-inflammatory properties related to physical exercise performed at moderate intensity, on inflammation and alterations in IMT are not clear in pediatric groups. Due to the importance that sport participation has assumed as a promoter of improvements in health and quality of life, it is necessary to understand its potential benefits for cardiovascular health during human growth.Sao Paulo Research Foundation-FAPESPCNPqSao Paulo State Univ, Postgrad Program Movement Sci, UNESP, Rio Claro, BrazilUNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, Roberto Simonsen St 305, BR-19060900 Presidente Prudente, BrazilVrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Dept Occupat Hlth, Amsterdam, NetherlandsUNESP, Dept Phys Educ, Lab Invest Exercise, LIVE, Presidente Prudente, BrazilUniv Fed Sao Paulo, UNIFESP, Postgrad Program Radiol, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Postgrad Program Radiol, Sao Paulo, BrazilFAPESP: 2013/06052-2FAPESP: 2015/04961-0CNPq: 476295/2013-0CNPq: 303725/2014-1Web of Scienc

Possible underestimation by sports medicine of the effects of early physical exercise practice on the prevention of diseases in adulthood

In modern society, combatting cardiovascular and metabolic diseases has been highlighted as an urgent global challenge. In recent decades, the scientific literature has identified that behavioral variables (e.g. smoking, unhealthy diet and physical inactivity) are related to the development of these outcomes and, therefore, preventive actions should focus on the promotion of physical exercise practice and a healthy diet, as well as combatting the smoking habit from an early age. The promotion of physical exercise in the general population has been suggested as a relevant goal by significant health organizations around the world. On the other hand, recent literature has indicated that physical exercise performed in early life prevents the development of diabetes mellitus, dyslipidemia and arterial hypertension during adulthood, although this protective effect seems to be independent of the physical activity performed during adulthood. Apparently, the interaction between physical exercise and human growth in early life constitutes an issue which is not completely understood by sports medicine. The aim of the present review was therefore to discuss recent evidence on the effects of physical exercise performed during childhood and adolescence on cardiovascular and metabolic outcomes in adulthood

Effect of concurrent training on risk factors and hepatic steatosis in obese adolescents

OBJETIVOAnalisar os efeitos de 20 semanas de treinamento concorrente sobre as variáveis de composição corporal, perfil lipídico e diagnóstico da esteatose hepática em adolescentes obesos.MÉTODOSRealizou-se um ensaio clínico aberto com 34 adolescentes obesos com idades entre 12 e 15 anos. Foram analisados gordura corporal total e de tronco, colesterol total e suas frações (HDL, LDL e VLDL) e triglicérides, sendo realizado exame de ultrassonografia de abdome superior para diagnosticar esteatose hepática. Os participantes foram submetidos ao treinamento concorrente (associação de treino com pesos e exercício aeróbio) três vezes por semana, com duração de uma hora-aula durante 20 semanas. Para o tratamento estatístico, foram realizados o teste t de Student pareado e a análise de frequência, a fim de verificar as reduções relativa e absoluta do diagnóstico da esteatose hepática, adotando-se p<0,05.RESULTADOSOs adolescentes estudados apresentaram melhoras significativas da composição corporal, com diminuição do percentual de gordura total, da massa gorda total, da gordura de tronco e do aumento da massa magra, além de redução do tamanho dos lóbulos do fígado, dos índices de prevalência da esteatose hepática, do colesterol total e LDL-colesterol.CONCLUSÕESO treinamento concorrente foi efetivo por promover melhorias significativas de variáveis da composição corporal e do perfil lipídico, além de reduzir a prevalência da esteatose hepática.OBJETIVOAnalizar los efectos de 20 semanas de entrenamiento concurrente sobre las variables de composición corporal, perfil lipídico y diagnóstico de la esteatosis hepática en adolescentes obesos.MÉTODOSSe realizó un ensayo clínico abierto con 34 adolescentes obesos con edades entre los 12 y los 15 años (13,7±1,17). Se analizaron grasa corporal total y de tronco, colesterol total y sus fracciones (HDL, LDL y VLDL) y triglicéridos, siendo realizado examen de ultrasonografía abdominal superior para diagnosticar esteatosis hepática. Los participantes fueron sometidos al entrenamiento concurrente (asociación de entrenamiento con pesos y ejercicio aeróbico) tres veces por semana, con duración de una hora clase durante 20 semanas. Para el tratamiento estadístico, se realizaron análisis descriptivo, prueba t de Student pareada y análisis de frecuencia, a fin de verificar las reducciones relativa y absoluta del diagnóstico de la esteatosis hepática, adoptando p<0,05.RESULTADOSLos adolescentes estudiados presentaron mejoras significativas de la composición corporal, con reducción del porcentaje de grasa total, de la masa gorda total, de la grasa de tronco y del aumento de masa magra, además de reducción del tamaño de los lóbulos del hígado, de los índices de prevalencia de la esteatosis hepática, del colesterol total y del LDL-colesterol.CONCLUSIONESEl entrenamiento concurrente fue efectivo por promover mejorías significativas de variables de la composición corporal y del perfil lipídico, además de reducir la prevalencia de la esteatosis hepática.OBJECTIVETo analyze the effects of a 20-week concurrent training on the variables of body composition, lipid profile, and fatty liver diagnosis in obese adolescents.METHODSAn open clinical trial was carried out with 34 obese adolescents aged between 12 and 15 years. Total body fat, trunk fat mass, total cholesterol and its fractions (HDL, LDL and VLDL), and triglycerides were analyzed; an upper abdominal ultrasound was performed in order to diagnose fatty liver. The participants underwent concurrent training (association of weight training with aerobic training) three times per week, lasting one hour for 20 weeks. Statistical analysis included paired Studentâ€(tm)s t-test and frequency analysis in order to verify the relative and absolute reductions of fatty liver diagnosis, being significant p<0.05.RESULTSThe studied adolescents showed statistically significant improvement in body composition, with a decrease of total body fat percentage, total fat mass, trunk fat, and an a increase in the lean body mass. They also presented reduced size of liver lobes, decrease in total cholesterol and in LDL-cholesterol, with a lower prevalence of fatty liver.CONCLUSIONSThe concurrent training was effective for promoting significant improvements in body fat composition and lipid profile variables, besides reducing fatty liver prevalence rate

Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study

Objective: To analyze the association of potential risk factors to health with body fatness and insulin resistance. Baseline measures of the ongoing longitudinal Analysis of Behaviors of Children During (ABCD) Growth Study. Materials and Methods: The sample was composed of 280 adolescents of both sexes (198 boys and 82 girls) aged from 10 to 18 years. Four risk factors were considered, as follows: no sports practice, skipping breakfast, poor sleep quality, and TV viewing. The outcomes considered were insulin resistance (HOMA-IR) and body fatness (densitometer scanner). Age, sex, maturity offset, and ethnicity were treated as covariates. Results: No sports practice and skipping breakfast were associated with higher body fatness (Sports practice: Wald: 8.786; p = 0.003. Breakfast: Wald: 9.364; p = 0.002). Poor sleep quality was related to a greater HOMA-IR index (Wald: 6.013; p = 0.014). Adolescents with &#8805;3 risk factors presented a higher risk of high HOMA-IR (OR = 4.89 (95%CI: 1.61 to 14.84)) than their counterparts with no risk factors. Conclusion: Lifestyle risk factors seem relevant to affect obesity and insulin resistance, while the aggregation of these risk factors affects insulin resistance, independent of adiposity

Treinamento concorrente e o treinamento funcional promovem alterações benéficas na composição corporal e esteatose hepática não alcoólica de jovens obesos

To compare the effect of concurrent and functional exercise training on body composition, lipid profile and non-alcoholic steatohepatitis in obese adolescents. Longitudinal/analytical study by non-random sampling carried out with 49 obese adolescents (n=36 in concurrent and n=13 in functional exercise training). Both protocols had 50% of the session designed to aerobic activities and the other half session to resistance and functional training (activities using self-body weight and dumbbells). Set data had normal distribution and the paired sample t test was applied. Concurrent exercise training decreased low density lipoprotein (-16.45%), total cholesterol (-11.55%), body fatness (-8.52%), trunk fatness (-9.95%) and increased fat free mass (5.05%). On the other hand, functional exercise training decrease body fatness (-4.97%), trunk fatness (-5.11%), intra-abdominal adiposity (-19,9%), increase fat free mass (4.18%) and occurrence of non-alcoholic steatohepatitis (reduction of 76.9%). Concurrent training seems a relevant tool to the treatment of non-alcoholic steatohepatitis in obese adolescents.Comparar o efeito do treinamento concorrente e o treinamento funcional na composição corporal, perfil lipídico e esteatose hepática não alcoólica (EHNA) em adolescentes obesos. Delineamento longitudinal. Amostra de 49 adolescentes obesos (treinamento concorrente[n=36]; treinamento funcional[n=13]). Nos dois tipos de treinamento físico 50% de atividade aeróbia, e 50% resistida. Tais treinamentos se diferem na atividade resistida (concorrente: musculação; funcional: peso do próprio corpo e/ou pesos livres). Dada a normalidade da distribuição, foi empregado Teste t de Student para dados pareados. O treinamento concorrente apresentou redução para variáveis LDL-c(-16,45%), CT(-11,55%), GC(-8,52%) e GT(-9,95%) e aumento na MCM(5,05%). Por outro lado, treinamento funcional apresentou alterações significativas na composição corporal tais como, GC(-4,97%), MCM(4,18%), GT(-5,11%) e GI(-19,90%). O treinamento funcional apresentou diminuição de 76,9% na ocorrência de EHNA, porém, devido a elevada prevalência desta doença, cabe salientar que o treinamento concorrente também foi eficaz para o tratamento da mesma em adolescentes obesos.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES