A Theoretical Investigation of the Geometries, Vibrational Frequencies, and Binding Energies of Several Mixed Alkali Halide Dimers

Results are presented from ab initio calculations on several mixed alkali halide dimers made up of Li, Na, F, and Cl. All of the dimers are investigated at the restricted Hartree–Fock level to provide ab initio estimates of geometries, vibrational frequencies, and binding energies. The dimer LiNaF2 is then treated using a variety of basis sets at the Hartree–Fock level, as well as at correlated levels (second‐order Møller–Plesset and coupled‐cluster singles and doubles) to examine the sensitivity of the calculations to use of higher levels of theory. The results are then compared to the experimental data available for the LiNaF2 molecule, previous theoretical results for the monomers, and recent semiempirical calculations on the mixed dimers

The Neutral Gas Dynamics of the Nearby Magellanic Irregular Galaxy UGCA 105

We present new low-resolution HI spectral line imaging, obtained with the Karl G. Jansky Very Large Array (JVLA), of the star-forming Magellanic irregular galaxy UGCA 105. This nearby (D = 3.39+/-0.25 Mpc), low mass [M_HI=(4.3+/-0.5)x10^8 Solar masses] system harbors a large neutral gas disk (HI radius ~7.2 kpc at the N_HI=10^20 cm^-2 level) that is roughly twice as large as the stellar disk at the B-band R_25 isophote. We explore the neutral gas dynamics of this system, fitting tilted ring models in order to extract a well-sampled rotation curve. The rotation velocity rises in the inner disk, flattens at 72+/-3 km/s, and remains flat to the last measured point of the disk (~7.5 kpc). The dynamical mass of UGCA 105 at this outermost point, (9+/-2)x10^9 Solar masses, is ~10 times as large as the luminous baryonic components (neutral atomic gas and stars). The proximity and favorable inclination (55 degrees) of UGCA 105 make it a promising target for high-resolution studies of both star formation and rotational dynamics in a nearby low-mass galaxy.Comment: The Astronomical Journal, in pres

A comparison between Asian and Australasia backpackers using cultural consensus analysis

This study tests the differences in the shared understanding of the backpacker cultural domain between two groups: backpackers from Australasia and backpackers from Asian countries. A total of 256 backpackers responded to a questionnaire administered in Kuala Lumpur, Bangkok and Krabi Province (Thailand). Cultural consensus analysis (CCA) guided the data analysis, to identify the shared values and the differences in the backpacker culture of the two groups. The findings revealed that while the two groups share some of the backpacker cultural values, some other values are distinctively different from one another. The study provides the first empirical evidence of the differences in backpacking culture between the two groups using CCA. Based on the study findings, we propose some marketing and managerial implications

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response