Dynamics of dual film formation in boundary lubrication of steels part II. Chemical analyses

Effective "breaking-in" of lubricated steel surfaces has been found to be due primarily to the rate of growth of "protective" films of oxides and compounds derived from the lubricant. The protection afforded by the films is strongly dependent on lubricant chemistry, steel composition, original surface roughness and the load/speed sequence or history in the early stages of sliding. Given the great number of variables involved it is not possible to follow more than a few of the chemical changes on surfaces using the electron, ion and X-ray column analytical instruments at the end of experiments. Ellipsometry was therefore used to monitor the formation and loss of dual protective films in real time, and detailed chemical analysis was done at various stages to calibrate the ellipsometer. This work is reported in three interlinking parts: I, Functional Nature and Mechanical Properties; II, Chemical Analyses; III, Real-time Monitoring with Ellipsometry.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29174/1/0000220.pd

Dynamics of dual film formation in boundary lubrication of steels part III. Real time monitoring with ellipsometry

Effective "breaking-in" of lubricated steel surfaces has been found to be due primarily to the rate of growth of "protective" films of oxides and compounds derived from the lubricant. The protection afforded by the films is strongly dependent on lubricant chemistry, steel composition, original surface roughness and the load/speed sequence or history in the early stages of sliding. Given the great number of variables involved it is not possible to follow more than a few of the chemical changes on surfaces using the electron, ion and X-ray column analytical instruments at the end of experiments. Ellipsometry was therefore used to monitor the formation and loss of dual protective films in real time, and detailed chemical analysis was done at various stages to calibrate the ellipsometer. This work is reported in three interlinking parts: I, functional nature and mechanical properties; II, chemical analyses; III, real-time monitoring with ellipsometry.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29175/1/0000221.pd

An optimized resilient advance bandwidth scheduling for media delivery services

Part 3: Evaluation and Experimental Study of Rich Network ServicesInternational audienceIn IP-based media delivery services, we often deal with predictable network load and traffic, making it beneficial to use advance reservations even when network failure occurs. In such a network, to offer reliable reservations, fault-tolerance related features should be incorporated in the advance reservation system. In this paper, we propose an optimized protection mechanism in which backup paths are selected in advance to protect the transfers when any failure happens in the network. Using a shared backup path protection, the proposed approach minimizes the backup capacity of the requests while guaranteeing 100% single link failure recovery. We have evaluated the quality and complexity of our proposed solution and the impact of different percentages of backup demands and timeslot sizes have been investigated in depth. The presented approach has been compared to our previously-designed algorithm as a baseline. Our simulation results reveal a noticeable improvement in request acceptance rate, up to 9.2%. Moreover, with fine-grained timeslot sizes and under limited network capacity, the time complexity of the proposed solution is up to 14% lower

Non-invasive brain stimulation techniques for the improvement of upper limb motor function and performance in activities of daily living after stroke: a systematic review and network meta-analysis

Objective: To compare the efficacy of non-invasive brain stimulation (NiBS) such as transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), theta-burst stimulation (TBS), and transcutaneous vagus nerve stimulation (taVNS) in upper limb stroke rehabilitation. Data sources: PubMed, Web of Science, and Cochrane databases were searched from January 2010 to June 2022. Data selection: Randomized controlled trials (RCT's) assessing the effects of "tDCS", "rTMS", "TBS", or "taVNS" on upper limb motor function and performance in activities of daily livings (ADLs) after stroke. Data extraction: Data were extracted by 2 independent reviewers. Risk of bias were was evaluated with the Cochrane Risk of Bias tool. Data synthesis: 87 RCTs with 3750 participants were included. Pairwise meta-analysis showed that all NiBS except continuous TBS (cTBS) and cathodal tDCS were significantly more efficacious than sham stimulation for motor function (Standard Meand Differerence (SMD) range 0.42 to 1.20) whereas taVNS, anodal tDCS, and both low and high frequency rTMS were significantly more efficacious than sham stimulation for ADLs (SMD range 0.54 to 0.99). NMA showed that taVNS was more effective than cTBS (SMD:1.00;95%CI(0.02 to 2.02), cathodal tDCS (SMD:1.07;95%CI(0.21 to 1.92) and Physical rehabilitation alone (SMD:1.46;95%CI(0.59 to 2.33)) for improving motor function. P-score found that taVNS is best ranked treatment in improving motor function (SMD: 1.20;95%CI(0.46 to 1.95) and ADLs (SMD:1.20;95%CI(0.45 to 1.94) after stroke. After taVNS, excitatory stimulation protocols (intermittent TBS, anodal tDCS and HF-rTMS) are most effective in improving motor function and ADLs after acute/sub-acute (SMD range 0.53 to 1.63) and chronic stroke (SMD range 0.39 to 1.16). Conclusions: Evidence suggests that excitatory stimulation protocols are the most promising intervention in improving upper limb motor function and performance in ADLs. taVNS appeared to be a promising intervention for stroke patients, but further large RCTs are required to confirm its relative superiority

Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours

Background: The human death-associated protein 3 (hDAP3) is a GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function.Methods: A search through publicly available microarray data sets showed 337 genes potentially coregulated with the DAP3 gene. The promoter sequences of these 337 genes and 70 out of 85 mitochondrial ribosome genes were analysed in silico with the DAP3 gene promoter sequence. The mitochondrial role of DAP3 was also investigated in the thyroid tumours presenting various mitochondrial contents. Results: The study revealed nine transcription factors presenting enriched motifs for these gene promoters, five of which are implicated in cellular growth (ELK1, ELK4, RUNX1, HOX11-CTF1, TAL1-ternary complex factor 3) and four in mitochondrial biogenesis (nuclear respiratory factor-1 (NRF-1), GABPA, PPARG-RXRA and estrogen-related receptor alpha (ESRRA)). An independent microarray data set showed the overexpression of ELK1, RUNX1 and ESRRA in the thyroid oncocytic tumours. Exploring the thyroid tumours, we found that DAP3 mRNA and protein expression is upregulated in tumours presenting a mitochondrial biogenesis compared with the normal tissue. ELK1 and ESRRA were also showed upregulated with DAP3. Conclusion: ELK1 and ESRRA may be considered as potential regulators of the DAP3 gene expression. DAP3 may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis

Advancement in the pressureless sintering of CP titanium using high-frequency induction heating

High-frequency induction heating is applied as an alternative heating source for pressureless sintering of commercially pure Ti powders, aiming to intensify the sintering process. The effects of the process parameters on the properties of the sintered material are systematically studied. The initial powder compact density is the most influential parameter permitting sintered structures with highly porous to almost fully dense appearance. Short heating time combined with sintering to temperatures just above the β-transus resulted in a strong diffusion bonding between the Ti powder particles, and grain growth is observed at the former boundaries of the neighboring powder particles. The dimpled appearance of the fracture surface at those regions confirmed the strong metallic interparticle bonding. Tensile properties comparable to those of Ti-Grade 3 and Ti-Grade 4 are achieved, which also demonstrates the efficiency of the induction sintering process. A mechanism explaining the fast and efficient sintering is proposed. The process has the added advantage of minimizing the oxygen pickup

Cloud computing: survey on energy efficiency

International audienceCloud computing is today’s most emphasized Information and Communications Technology (ICT) paradigm that is directly or indirectly used by almost every online user. However, such great significance comes with the support of a great infrastructure that includes large data centers comprising thousands of server units and other supporting equipment. Their share in power consumption generates between 1.1% and 1.5% of the total electricity use worldwide and is projected to rise even more. Such alarming numbers demand rethinking the energy efficiency of such infrastructures. However, before making any changes to infrastructure, an analysis of the current status is required. In this article, we perform a comprehensive analysis of an infrastructure supporting the cloud computing paradigm with regards to energy efficiency. First, we define a systematic approach for analyzing the energy efficiency of most important data center domains, including server and network equipment, as well as cloud management systems and appliances consisting of a software utilized by end users. Second, we utilize this approach for analyzing available scientific and industrial literature on state-of-the-art practices in data centers and their equipment. Finally, we extract existing challenges and highlight future research directions

Total and corrected antioxidant capacity in hemodialyzed patients

BACKGROUND: Oxidative stress may play a critical role in the vascular disease of end stage renal failure and hemodialysis patients. Studies, analyzing either discrete analytes and antioxidant substances, or the integrated total antioxidant activity of human plasma during hemodialysis, give contradictory results. METHODS: Recently, we have introduced a new automated method for the determination of Total Antioxidant Capacity (TAC) of human plasma. We have serially measured TAC and corrected TAC (cTAC: after subtraction of the interactions due to endogenous uric acid, bilirubin and albumin) in 10 patients before the onset of the dialysis session, 10 min, 30 min, 1 h, 2 h and 3 h into the procedure and after completion of the session. RESULTS: Our results indicate that TAC decreases, reaching minimum levels at 2 h. However, corrected TAC increases with t(1/2 )of about 30 min. We then repeated the measurements in 65 patients undergoing dialysis with different filters (36 patients with ethylene vinyl alcohol copolymer resin filter -Eval-, 23 patients with two polysulfone filters -10 with F6 and 13 with PSN140-, and 6 patients with hemophan filters). Three specimens were collected (0, 30, 240 min). The results of this second group confirm our initial results, while no significant difference was observed using either filter. CONCLUSIONS: Our results are discussed under the point of view of possible mechanisms of modification of endogenous antioxidants, and the interaction of lipid- and water-soluble antioxidants