Financiación de las universidades: la experiencia italiana en contexto europeo

Los autores ofrecen un sucinto informe actualizado de la financiación de las universidades en Italia. No muy distante ni muy distinto del caso español, contribuye a la meditación comparativa

Manage with care: the frailty of self-connections in the European airport network

AbstractThis study evaluates the attractiveness of self-hubbing in terms of the (a) symmetry of itineraries and the consequences for passengers in the case of missed flights. We compute the most attractive European origin-destination (O-D) pairs through self-connection and evaluate their robustness by estimating the expected delays relative to connecting times and the travel options available when a connection is missed.Results show that the potential of self-connecting markets is reduced when accounting for asymmetrical travel options and the consequences for travelers in the case of missed flights. In terms of frequencies, self-connecting passengers are, on average, found to have fewer alternatives to complete a given O-D pair than in the case of alliance-based connections (− 33%). Our findings moderate the confidence of past evidence on self-hubbing in light of the concrete reliability of self-connections for passengers. The itinerary choice made by passengers inevitably depends on the evaluation of travel quality attributes related to the (a) symmetry of the itineraries and the costs incurred through missed connections

Universities' attractiveness to students: The Darwinism effect

AbstractDue to significant government cuts to Higher Education funding in Southern European systems, their already underfunded universities were forced to increasingly compete for students as sources of additional revenue. Concurrently, families and students that continued to afford participation in Higher Education became more selective when choosing a university, realising the riskier investment that Higher Education participation had become. Through a competing destinations model and relying on all Italian private and public universities, this study finds that the competition forces characterising universities' attractiveness over the last decade have changed since the financial crisis of 2008. In a context of lower demand for Higher Education, the competition for students grew and universities in close proximity were better prepared to face the new challenges, leading to the growth of Higher Education clusters

Universities’ responses to crises : the influence of competition and reputation on tuition fees

Author's accepted manuscript.Available from 10/11/2021.This is a post-peer-review, pre-copyedit version of an article published in Higher Education. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10734-020-00622-2.acceptedVersio

Cardiovascular Imaging and Theranostics in Cardiovascular Pharmacotherapy

Imaging plays a pivotal role in the diagnostic and prognostic assessment of cardiovascular diseases. During the past two decades, there has been an expansion of the available imaging techniques, some of which are now part of routine clinical practice. Cardiovascular imaging of atherosclerosis is a useful instrument, and it can corroborate and expand pathophysiological evidence on cardiovascular disease, providing proof of concept for medical therapy and can predict its responsiveness, and it may be able to be used as surrogate endpoints for clinical trials. Theranostics is an emerging therapy that combines imaging and therapeutic functions, using imaging-based therapeutic delivery systems. Theranostics could partially overcome current imaging limitations and translate experimental evidence and large-scale trials assessing clinical endpoints, rationalising cardiovascular drug development and paving the way to personalised medicine. The medical community cannot overlook the use of cardiovascular imaging as a complementary and supportive adjunct to trials investigating clinical endpoints, which remain the mainstay for investigating the efficacy and safety of cardiovascular pharmacotherapy

Using citation metrics as part of academic recruitment decisions leads to an increase in self-citations

The use of citation metrics in academic hiring and promotion decisions was intended as a response to important and legitimate concerns over the meritocracy of recruitment procedures. However, evidence suggests that doing so distorts scientists' behaviour and increases the risk that these measures become unreliable. Marco Seeber, Mattia Cattaneo, Michele Meoli and Paolo Malighetti investigated the use of citation metrics within the Italian higher education system and found that scientists responded to a new regulation linking career advancement to metric scores by increasingly citing their own work. Policymakers should take note and use bibliometric tools as a means of informing rather than determining evaluations, as advocated by initiatives such as DORA and the Leiden Manifesto

Manage with care: the frailty of self-connections in the European airport network

This study evaluates the attractiveness of self-hubbing in terms of the (a) symmetry of itineraries and the consequences for passengers in the case of missed flights. We compute the most attractive European origin-destination (O-D) pairs through self-connection and evaluate their robustness by estimating the expected delays relative to connecting times and the travel options available when a connection is missed. Results show that the potential of self-connecting markets is reduced when accounting for asymmetrical travel options and the consequences for travelers in the case of missed flights. In terms of frequencies, self-connecting passengers are, on average, found to have fewer alternatives to complete a given O-D pair than in the case of alliance-based connections (− 33%). Our findings moderate the confidence of past evidence on self-hubbing in light of the concrete reliability of self-connections for passengers. The itinerary choice made by passengers inevitably depends on the evaluation of travel quality attributes related to the (a) symmetry of the itineraries and the costs incurred through missed connections. Document type: Articl

Data on consistency among different methods to assess atherosclerotic plaque echogenicity on standard ultrasound and intraplaque neovascularization on contrast-enhanced ultrasound imaging in human carotid artery

AbstractHere we provide the correlation among different carotid ultrasound (US) variables to assess echogenicity n standard carotid US and to assess intraplaque neovascularization on contrast enhanced US. We recruited 45 consecutive subjects with an asymptomatic≥50% carotid artery stenosis. Carotid plaque echogenicity at standard US was visually graded according to Gray–Weale classification (GW) and measured by the greyscale median (GSM), a semi-automated computerized measurement performed by Adobe Photoshop®. On CEUS imaging IPNV was graded according to the visual appearance of contrast within the plaque according to three different methods: CEUS_A (1=absent; 2=present); CEUS_B a three-point scale (increasing IPNV from 1 to 3); CEUS_C a four-point scale (increasing IPNV from 0 to 3). We have also implemented a new simple quantification method derived from region of interest (ROI) signal intensity ratio as assessed by QLAB software. Further information is available in “Contrast-enhanced ultrasound imaging of intraplaque neovascularization and its correlation to plaque echogenicity in human carotid arteries atherosclerosis (M. Cattaneo, D. Staub, A.P. Porretta, J.M. Gallino, P. Santini, C. Limoni et al., 2016) [1]

Intractable coronary fibromuscular dysplasia leading to end‐stage heart failure and fatal heart transplantation

Coronary fibromuscular dysplasia is uncommon, and even rarer its unstable and recurrent course. We present the unique case of a 52-year-old woman who underwent in total 12 coronary angiographies and three percutaneous coronary intervention within 24 months because of repetitive acute coronary syndromes due to refractory spasm, dissection, restenosis all leading to end-stage heart failure, and heart transplantation. The patient died 12 days after the heart transplantation complicated by intraoperative acute thrombotic occlusion of left anterior descending artery of the graft despite normal pretransplant coronary angiography. Autopsy of the recipient heart confirmed coronary fibromuscular dysplasia with massive intimal hyperplasia and restenosis

Improved Prognostic Prediction in Never-Smoker Lung Cancer Patients by Integration of a Systemic Inflammation Marker with Tumor Immune Contexture Analysis

Almost 25% of lung cancers (LCs) occur in never-smokers. LC inflammatory profile, based on plasma C-reactive protein levels (CRP), predicts mortality, independently by smoking-status. We hypothesized that: CRP could be associated with tumor immune contexture (TIC) in never-smokers and both these two parameters may improve their prognosis. Sixty-eight never-smokers LC patients with high or low CRP were selected. The programmed cell death protein 1 (PD-1) and its ligand (PD-L1), the human leukocyte antigens (HLA-DR and HLA-I), CD8, CD4, CD3, CD33, CD163, and CD68 were evaluated by immunohistochemistry on surgical samples given TIC evaluation. The classification model based on TIC scores was generated by Classification and Regression Tree analysis. Tumor mutational burden was evaluated by targeted next-generation sequencing. Exclusively high CRP (H-CRP) subset showed PD-L1 expression in 35% of LC as well as lower HLA-I and HLA-DR in their stromal cells. CD3, CD4, CD8, HLA-I, HLA-DR tumor cells staining were associated with a "low inflammatory profile" subset. CRP and LC immune profiles drive clinical outcome: 5-year survival 88% against 8% was associated with low and high-risk profiles (p< 0.0001). Clinical outcome prediction in never-smoker LC patients may be improved by both CRP and tumor immune contexture evaluation