Distribution of the Dirac modes in QCD

It was established that distribution of the near-zero modes of the Dirac operator is consistent with the Chiral Random Matrix Theory (CRMT) and can be considered as a consequence of spontaneous breaking of chiral symmetry (SBCS) in QCD. The higher-lying modes of the Dirac operator carry information about confinement physics and are not affected by SBCS. We study distributions of the near-zero and higher-lying modes of the overlap Dirac operator within $N_F = 2$ dynamical simulations. We find that distributions of both near-zero and higher-lying modes are the same and follow the Gaussian Unitary Ensemble of Random Matrix Theory. This means that randomness, while consistent with SBCS, is not a consequence of SBCS and is related to some more general property of QCD in confinement regime.Comment: Contribution to Lattice 2017 proceedings, 18-24 June, 2017, Granada, Spai

Endoscopic Third Ventriculostomy Training to Treat Spina Bifida Related Hydrocephalus in Africa: A Literature Review

Undergraduate Theoretica

Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

Alternative pre-mRNA splicing (AS) is a major mechanism that allows proteomic variability in eukaryotic cells. However, many AS events result in mRNAs containing a premature termination codon, which are degraded by nonsense-mediated mRNA decay (NMD) pathway. We have previously demonstrated that human rpL3 autoregulates its expression through the association of AS with NMD. In fact, overexpression of rpL3 promotes downregulation of canonical splicing and upregulation of alternative splicing that produces an NMD-targeted mRNA isoform. The result of these events is a decreased production of rpL3. We have also identified heterogeneous nuclear ribonucleoprotein (hnRNP) H1 as a splicing factor involved in the regulation of rpL3 alternative splicing and identified its regulatory cis-elements within intron 3 transcript. Here, we report that NPM and KHSRP are two newly identified proteins involved in the regulation of rpL3 gene expression via AS-NMD. We demonstrate that hnRNP H1, KHSRP and NPM can be found associated, and present also in ribonucleoproteins (RNPs) including rpL3 and intron 3 RNA in vivo, and describe protein-protein and RNA-protein interactions. Moreover, our data provide an insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene

Fit of different linear models to the lactation curve of Italian water buffalo

Mathematical modelling of lactation curve by suitable functions of time, widely used in the dairy cattle industry, can represent also for buffaloes a fundamental tool for management and breeding decision, where average curves are considered, and for genetic evaluation by random regression models, where individual patterns are fitted. Average lactation curves of Italian Buffalo cows have been fitted with good results (Catillo et al., 2002) whereas there is a lack of information on individual fitting.Aim of the present work is to check performances of some of the most currently used empirical models in fitting both average and individual lactation curves of Italian water buffaloes

Post-transcriptional regulatory strategies and extraribosomal functions of human rpL3

Comprensione del ruolo di alcuni putativi interattori proteici di rpL3 e del suo trascritto primario identificati mediante spettrometria di massa sui prodotti di esperimenti di “GST Pull Down” e “RNA Pull Down”, quali hnRNP H1, NPM e KHSRP, nella regolazione post-trascrizionale del gene di rpL3

On SU(2)CSSU(2)_{CS}-like groups and invariance of the fermionic action in QCD

In this work, we introduce some new $U(1)$ symmetry groups of the free fermionic action in euclidean space-time, which are a consequence of parity and time-reversal symmetries. Afterwards, we discuss how the introduction of a gauge interaction affects the invariance of the action, with special reference to QCD. Moreover, inspired by recent QCD lattice results of \textit{Glozman et al.}, in which an interesting and unexpected symmetry group has been observed, namely $SU(2)_{CS}$ (that contains $U(1)_A$ as subgroup), we build other $SU(2)_{CS}$-like groups in euclidean space-time using the previous introduced $U(1)$ groups. Finally we argue about the possible invariance of the fermionic action with respect these new $SU(2)_{CS}$-like groups and its consequence on the hadron temporal correlators.Comment: 21 pages + appendice