173 research outputs found

    Genetic Variants For Head Size Share Genes and Pathways With Cancer

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    The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer

    Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

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    Brouwer et al. present preclinical evidence in support of a COVID-19 vaccine candidate, designed as a self-assembling two-component protein nanoparticle displaying multiple copies of the SARS-CoV-2 spike protein, which induces strong neutralizing antibody responses and protects from high-dose SARS-CoV-2 challenge.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication i

    Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

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    A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

    stairs and fire

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    Comentarios sobre “La Costa Rica cafetalera en contexto comparado”, de Lowell Gudmundson

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    Análisis del trabajo de Lowell Gudmunson a la luz de la historia del café en Colombia. Se hace referencia a cuatro aspectos: 1) los orígenes de la pequeña propiedad en la producción cafetalera colombiana; 2) los sistemas de trabajo; 3) el conflicto social en las regiones cafetaleras; y 4) la significación económica, social y política del pequeño caficultor, en la óptica de los investigadores colombianistas

    Comentarios sobre “La Costa Rica precafetalera en el contexto comparado”, de Lowell Gudmunson

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    ResumenAnálisis del trabajo de Lowell Gudmunson a la luz de la historia del café en Colombia. Se hace referencia a cuatro aspectos: 1) los orígenes de la pequeña propiedad en la producción cafetalera colombiana; 2) los sistemas de trabajo; 3) el conflicto social en las regiones cafetaleras; y 4) la significación económica, social y política del pequeño caficultor, en la óptica de los investigadores colombianistas

    Arnaud Tellier, Expériences traumatiques et écriture, Paris, Anthropos Economica, 1998.

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    Le Grand-Sébille Catherine. Arnaud Tellier, Expériences traumatiques et écriture, Paris, Anthropos Economica, 1998. In: Gradhiva : revue d'histoire et d'archives de l'anthropologie, n°26, 1999. Dossier : Ernesto de Martino. pp. 129-130

    Naissances marquées, rituels manqués

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    Le Grand-Sébille Catherine. Naissances marquées, rituels manqués. In: Gradhiva : revue d'histoire et d'archives de l'anthropologie, n°19, 1996. Dossier : Naître en marge. pp. 77-84

    Etude de la dynamique de différents liquides surfondus par diffusion de la lumière à température et pression variables

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    PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

    La conciliation de la vie professionnelle et familiale (une réalité à mieux prendre en compte)

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    LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF
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