Human Illnesses Caused by Opisthorchis felineus Flukes, Italy

We report 2 outbreaks of Opisthorchis felineus infection caused by the consumption of tench filets (Tinca tinca) from a lake in Italy. Of the 22 infected persons, 10 (45.4%) were asymptomatic. When present, symptoms (fever, nausea, abdominal pain, and myalgias) were mild. Eosinophilia occurred in all infected persons

Treatment of olecranon fractures in childhood: A systematic review

Background: Literature over the last 20 years provides evidence for a surgical treatment of displaced olecranon fractures in children, this is usually obtained with commonly proposed methods, although there is no general agreement about the best recommended technique. Aim: Identifying the best surgical technique in displaced olecranon fractures in children and the role of associated fractures in the prognosis of these lesions, by analyzing the most relevant studies on this topic. Methods: A literature search was performed in MEDLINE database and Scopus database. Articles reporting clinical outcomes of pediatric patients affected by olecranon fractures treated surgically were identified. Results: The initial search produced 111 studies, with 8 fulfilling the eligibility criteria of our study. Selected articles (2002–2022) included 122 patients overall. Conclusion: Displaced olecranon fractures, occurring during skeletal growth and surgically treated, generally have good results, although we are unable to recommend the best surgical treatment based on our review. In most cases, they are intra-articular fractures; thus, the overall goal is to get an anatomic reduction that in some cases cannot be obtained by percutaneous techniques. Tension band suture is the preferred device, although it is not recommended in adolescence for the high risk of fixation failure. Associated lesions may affect results

Tuberculosis and migrants in the local health unit of Viterbo

Tuberculosis is still considered a worldwide health problem. In recent years, the stable decrease of tuberculosis notification in Europe is probably due to a particular underlying epidemiological trend: increase of tuberculosis notification in foreign born people living in low endemic countries, and a proportional decrease in the native population. This trend exists also in Italy, where tuberculosis incidence is low (5.2/100.000 inhabitants). Considering the high number of migrants in Viterbo Province after the humanitarian operation“Mare Nostrum”, we analyzed the local health unit (ASL) database to calculate tuberculosis notifications in this area. During the period 2013-2014, Viterbo Province data were similar to European data. Data on age, gender, and nationality are provided and discussed. It is noteworthy the identification of two cases in Nigerian patients that triggered a difficult epidemiological investigation due to the high number of people (migrants, social and healthcare workers) with whom they came into contact (174) and the problems in locating migrants moved to other Italian regions, thus highlighting the need for a constantly updated record of the migrant-hosting facilities

Prevalence of HDV infection in Central Italy has remained stable across the last two decades with dominance of sub-genotypes 1 and characterized by elevated viral replication

Background: HDV-prevalence in Italy and its fluctuations over-time are controversial. Furthermore, an extensive characterization of HDV-infected patients is still missing. Methods: The rate of HDV-seroprevalence and HDV-chronicity was assessed in 1,579 HBsAg+patients collected from 2005 to 2022 in Central-Italy. Results: 45.3% of HBsAg+patients received HDV-screening with an increasing temporal-trend: 15.6% (2005-2010), 45.0% (2011-2014), 49.4% (2015-2018), 71.8% (2019-2022). By multivariable-model, factors correlated with the lack of HDV-screening were ALT<2ULN and previous time-windows (P<0.002). Furthermore, 13.4% of HDV-screened patients resulted anti-HDV+ with a stable temporal trend. Among them, 80.8% had detectable HDV-RNA (median[IQR]:4.6[3.6-5.6]logcopies/ml) with altered ALT in 89.3% (median[IQR]:92[62-177]U/L). Anti-HDV+ patients from Eastern/South-eastern Europe were younger than Italians (44[37-54] vs 53[47-62]years, P<0.0001), less frequently NUC-treated (58.5% vs 80%, P=0.026) with higher HDV-RNA (4.8[3.6-5.8] vs 3.9[1.4-4.9]logcopies/ml, P=0.016) and HBsAg (9,461[4,159-24,532] vs 4,447[737-13,336]IU/ml, P=0.032). Phylogenetic-analysis revealed the circulation of HDV subgenotype-1e (47.4%) and -1c (52.6%). Notably, subgenotype-1e correlated with higher ALT than 1c (168[89-190] vs 58[54-88]U/l, P=0.015) despite comparable HDV-RNA. Conclusion: HDV-screening awareness is increasing over-time even if some gaps persist to achieve HDV-screening in all HBsAg+patients. HDV prevalence in tertiary-care centers tends to scarcely decline in native/non-native patients. Detection of subgenotypes, triggering variable inflammatory stimuli, supports the need to expand HDV molecular characterization

Awareness, discussion and non-prescribed use of HIV pre-exposure prophylaxis among persons living with HIV/AIDS in Italy: a Nationwide, cross-sectional study among patients on antiretrovirals and their treating HIV physicians

Background: Before Pre-Exposure Prophylaxis (PrEP) was officially recommended and made available, a few surveys among gay and bisexual men, and persons living with HIV/AIDS (PLWHA), identified an informal use of antiretrovirals (ARVs) for PrEP among HIV-negative individuals. Before PrEP availability in Italy, we aimed to assess whether PLWHA in Italy shared their ARVs with HIV-negative individuals, whether they knew people who were on PrEP, and describe the level of awareness and discussion on this preventive measure among them and people in their close circle. Methods: Two anonymous questionnaires investigating personal characteristics and PrEP awareness, knowledge, and experience were proposed to HIV specialists and their patients on ARVs in a one-week, cross-sectional survey (December 2013-January 2014). Among PLWHA, a Multivariable Logistic Regression analysis was conducted to identify factors associated with PrEP discussion with peers (close circle and/or HIV associations), and experience (use in close circle and/or personal ARV sharing). Results: Eighty-seven specialists in 31 representative Infectious Diseases departments administered the questionnaire to 1405 PLWHA. Among specialists, 98% reported awareness, 65% knew the dosage schedule, and 14% had previously suggested or prescribed PrEP. Among PLWHA, 45.6% were somehow aware, discussed or had direct or indirect experience of PrEP: 38% "had heard" of PrEP, 24% were aware of studies in HIV-negative individuals demonstrating a risk reduction through the use of ARVs, 22% had discussed PrEP, 12% with peers; 9% reported PrEP use in close circle and 1% personal ARV sharing. Factors predictive of either PrEP discussion with peers or experience differed between men and women, but across all genders were mainly related to having access to information, with HIV association membership being the strongest predictor. Conclusions: At a time and place where there were neither official information nor proposals or interventions to guide public policies on PrEP in Italy, a significant number of PLWHA were aware of it, and approximately 10% reported PrEP use in their close circle, although they rarely shared their ARVs with uninfected people for this purpose. Official policies and PrEP availability, along with implementation programs, could avoid risks from uncontrolled PrEP procurement and self-administration practices