Participación en la Primera Competencia Nacional de Vivienda Sustentable Resistente a Fenómenos Naturales para Estudiantes de Arquitectura

En este reporte se presentará el proceso que llevamos a cabo para la realización de nuestro proyecto como participantes en la primera competencia nacional de vivienda sustentable resistente a fenómenos naturales para estudiantes de arquitectura, desde el análisis que llevamos a cabo para escoger una locación y sus fenómenos naturales, así como los materiales y el diseño necesarios para cumplir con los requisitos que el concurso nos pedía

Core set of the International Classification of Functioning for spinal cord injury: instrument construction and validation

The research aimed to describe the instrument development and validation process based on the brief Core Set of the International Classification of Functioning, Disability and Health for individuals with Acute Spinal Cord Injury. In the methodological study, an instrument was developed to evaluate the functionality of individuals with acute traumatic spinal cord injury. The face and content validation of the instrument was performed by an expert committee, understanding the steps recommended in the literature. As part of this process, a pretest was performed with 10 individuals with acute traumatic spinal cord injury with up to 6 months of injury. In the results, in most items of the instrument, participants made suggestions to modify technical terms, to be replaced or reformulated for better understanding by the target audience. For data analysis the minimum agreement established was 80%. In conclusion, the contribution of the study refers to the possibility of using an innovative tool by the multidisciplinary team in clinical practice.Objetivo: Descrever o processo de desenvolvimento e validação do instrumento baseado no Core Set resumido da Classificação Internacional da Funcionalidade, Incapacidade e Saúde para indivíduos com lesão medular aguda. Método: No estudo metodológico foi desenvolvido um instrumento para avaliação da funcionalidade de indivíduos com lesão medular aguda traumática. A validação de face e conteúdo do instrumento foi realizada por um comitê de especialistas, compreendendo as etapas preconizadas na literatura. Como parte desse processo, foi realizado o pré-teste, com 10 indivíduos com lesão medular aguda traumática, com até 6 meses de lesão. Resultados: Na maioria dos itens do instrumento, os participantes fizeram sugestões que visavam à modificação de termos técnicos, para serem substituídos ou reformulados para melhor compreensão pelo público alvo. Para a análise de dados o mínimo de concordância estabelecido foi de 80%. Conclusão: A contribuição do estudo refere-se à possibilidade de utilizar uma ferramenta inovadora pela equipe multidisciplinar na prática clínica

Intervención con madera en la cubierta del nuevo edificio de Arte y Cultura

En este reporte, se presentará el proceso que se llevó a cabo en la segunda parte de este PAP. Trabajamos en conjunto con el departamento de encargados de construcción en ITESO para proponer una versión del nuevo edificio de arte y cultura hecho con madera. Nuestro equipo trabajó el tema de la cubierta, con los planos que nos proporcionaron se vio la manera de reemplazar o mejorar el diente de sierra que se tenía propuesto, utilizando como material, la madera

SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and prognosis of disease severity outcome. Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, it is still unclear whether direct SARS-CoV-2 infection of immune cells could also play a role in this scenario by harboring viral replication. We found that monocytes, as well as both B and T lymphocytes, were susceptible to SARS-CoV-2 infection in vitro, accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis. In addition, flow cytometry and immunofluorescence analysis revealed that SARS-CoV-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019 (COVID-19) patients. The rates of SARS-CoV-2-infected monocytes in peripheral blood mononuclear cells from COVID-19 patients increased over time from symptom onset, with SARS-CoV-2-positive monocytes, B cells, and CD4+ T lymphocytes also detected in postmortem lung tissue. These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in COVID-19 patients might have important implications for disease pathogenesis and progression, immune dysfunction, and virus spread within the host