4,056 research outputs found
Improved maximum likelihood estimators in a heteroskedastic errors-in-variables model
This paper develops a bias correction scheme for a multivariate
heteroskedastic errors-in-variables model. The applicability of this model is
justified in areas such as astrophysics, epidemiology and analytical chemistry,
where the variables are subject to measurement errors and the variances vary
with the observations. We conduct Monte Carlo simulations to investigate the
performance of the corrected estimators. The numerical results show that the
bias correction scheme yields nearly unbiased estimates. We also give an
application to a real data set.Comment: 12 pages. Statistical Paper
Shaping the Internet: 10 Years of IXP Growth
Over the past decade, IXPs have been playing a key role in enabling interdomain connectivity. Their traffic volumes have grown dramatically and their physical presence has spread throughout the world. While the relevance of IXPs is undeniable, their long-term contribution to the shaping of the current Internet is not fully understood yet. In this paper, we look into the impact on Internet routes of the intense IXP growth over the last decade. We observe that while in general IXPs only have a small effect in path shortening, very large networks do enjoy a clear IXP-enabled path reduction. We also observe a diversion of the routes, away from the central Tier-1 ASes supported by IXPs. Interestingly, we also find that whereas IXP membership has grown, large and central ASes have steadily moved away from public IXP peerings, whereas smaller ones have embraced them. Despite all this changes, we find though that a clear hierarchy remains, with a small group of highly central network
Conformal weights in the Kerr/CFT correspondence
It has been conjectured that a near-extreme Kerr black hole is described by a
2d CFT. Previous work has shown that CFT operators dual to axisymmetric
gravitational perturbations have integer conformal weights. In this paper, we
study the analogous problem in 5d. We consider the most general near-extreme
vacuum black hole with two rotational symmetries. This includes Myers-Perry
black holes, black rings and Kaluza-Klein black holes. We find that operators
dual to gravitational (or electromagnetic or massless scalar field)
perturbations preserving both rotational symmetries have integer conformal
weights, the same for all black holes considered.Comment: 19 page
Impact of mechanical ventilation on the functional status in patients admitted to the intensive care unit
What do -ray bursts look like?
There have been great and rapid progresses in the field of -ray
bursts (denoted as GRBs) since BeppoSAX and other telescopes discovered their
afterglows in 1997. Here, we will first give a brief review on the
observational facts of GRBs and direct understanding from these facts, which
lead to the standard fireball model. The dynamical evolution of the fireball is
discussed, especially a generic model is proposed to describe the whole
dynamical evolution of GRB remnant from highly radiative to adiabatic, and from
ultra-relativistic to non-relativistic phase. Then, Various deviations from the
standard model are discussed to give new information about GRBs and their
environment. In order to relax the energy crisis, the beaming effects and their
possible observational evidences are also discussed in GRB's radiations.Comment: 10 pages, Latex. Invited talk at the Pacific Rim Conference on
Stellar Astrophysics, Hong Kong, China, Aug. 199
The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations
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State of the California current 2012-13: No such thing as an “average” year
This report reviews the state of the California Current System (CCS) between winter 2012 and spring 2013, and includes observations from Washington State to Baja California. During 2012, large-scale climate modes indicated the CCS remained in a cool, productive phase present since 2007. The upwelling season was delayed north of 42°N, but regions to the south, especially 33° to 36°N, experienced average to above average upwelling that persisted throughout the summer. Contrary to the indication of high production suggested by the climate indices, chlorophyll observed from surveys and remote sensing was below average along much of the coast. As well, some members of the forage assemblages along the coast experienced low abundances in 2012 surveys. Specifically, the concentrations of all lifestages observed directly or from egg densities of Pacific sardine, Sardinops sagax, and northern anchovy, Engraulis mordax, were less than previous years’ survey estimates. However, 2013 surveys and observations indicate an increase in abundance of northern anchovy. During winter 2011/2012, the increased presence of northern copepod species off northern California was consistent with stronger southward transport. Krill and small-fraction zooplankton abundances, where examined, were generally above average. North of 42°N, salps returned to typical abundances in 2012 after greater observed concentrations in 2010 and 2011. In contrast, salp abundance off central and southern California increased after a period of southward transport during winter 2011/2012. Reproductive success of piscivorous Brandt’s cormorant, Phalacrocorax penicillatus, was reduced while planktivorous Cassin’s auklet, Ptychoramphus aleuticus was elevated. Differences between the productivity of these two seabirds may be related to the available forage assemblage observed in the surveys. California sea lion pups from San Miguel Island were undernourished resulting in a pup mortality event perhaps in response to changes in forage availability. Limited biological data were available for spring 2013, but strong winter upwelling coastwide indicated an early spring transition, with the strong upwelling persisting into early summer
Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease
Background
Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes.
Methods
We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosis < 60) and 141 non-aggressive (low clinical grade, age of diagnosis ≥60) PrCa cases. We conducted rare variant association analyses at gene and gene set levels using SKAT and Bayesian risk index techniques. GO term enrichment analysis was performed for genes with the highest differential burden of rare disruptive variants.
Results
Protein truncating variants (PTVs) in specific DNA repair genes were significantly overrepresented among patients with the aggressive phenotype, with BRCA2, ATM and NBN the most frequently mutated genes. Differential burden of rare variants was identified between metastatic and non-aggressive cases for several genes implicated in angiogenesis, conferring both deleterious and protective effects.
Conclusions
Inherited PTVs in several DNA repair genes distinguish aggressive from non-aggressive PrCa cases. Furthermore, inherited variants in genes with roles in angiogenesis may be potential predictors for risk of metastases. If validated in a larger dataset, these findings have potential for future clinical application
Evolutionary Analysis of Mitogenomes from Parasitic and Free-Living Flatworms
Copyright: © 2015 Solà et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article
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