Difusión del paisaje y del patrimonio rural de la obras públicas a través de las nuevas tecnologías

El estudio del paisaje y del patrimonio de obras públicas, relativamente reciente en España, ha adolecido de adecuados cauces para la transferencia de ese conocimiento. El proyecto piloto de la Red Rural Nacional denominado Valoración del Patrimonio Rural de la Obra Pública (VAPROP), que lleva a cabo la Fundación Miguel Aguiló, ha desarrollado aplicaciones móviles para permitir a los usuarios acceder a contenidos ordenados y de alta calidad, aplicaciones que también establecen cauces para la respuesta de los usuarios, lo que sirve para ampliar, mejorar y validar la información contenida. La difusión apoyada en las TIC es una más entre las acciones llevadas a cabo por el proyecto, y desde su lanzamiento al público general se ha constatado un creciente interés por el uso de esta herramienta que permite a cada usuario la configuración de un itinerario personalizado, lo que posibilita la planificación del recorrido. Durante el mismo es posible la localización precisa, el acceso a información rigurosa y la observación de obras públicas de alto interés patrimonial insertas en su territorio

Mobile Applications, Geolocation and Information Technologies for the Study and Communication of the Heritage Value of Public Works

Public works’ relationship with the landscape should be among the factors addressed in heritage studies. Their association with place defines their purpose while contributing to the construction of the cultural landscape. Unawareness of the existence of public works is their most powerful enemy. Inventorying and cataloguing are therefore imperative in any study of these assets. The research described here drew from information technologies to develop cost-free mobile apps in an innovative approach to dissemination with the aim to enhance public awareness of and esteem for such elements. The applications described, which are all author-developed and designed to promote Spain’s heritage public works, address the heritage value of rural public works (VAPROP_Rutas), geolocation of the built heritage (GEOPACK), heritage public works on the River Duero (PHDuero), major works of engineering (GOING) and geolocation of Eduardo Torroja’s public works (underway). All these applications build on the geo-positioning features of mobile handsets and are characterised by simple and intuitive interfaces for ready accessibility by the public at large. Users may participate in the experience by entering useful information, new content and suggestions. These apps deploy the latest technologies to enhance the understanding and appreciation of civil works by explaining their territorial, social and cultural significance

Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis

Altres ajuts: Agaur SGR468 to M.A.M-R. A.P.-G. is supported by a 'Doctorats Industrials' predoctoral fellowship (AGAUR). H.H. is a Miguel Servet (CP14/00229) researcher funded by the Spanish Institute of Health Carlos III (ISCIII)Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) of CCCTC-binding factor (CTCF) and meiotic cohesins, coupled with confocal and super-resolution microscopy. Spermatogonia presents well-defined compartment patterns and topological domains. However, chromosome occupancy and compartmentalization are highly re-arranged during prophase I, with cohesins bound to active promoters in DNA loops out of the chromosomal axes. Compartment patterns re-emerge in round spermatids, where cohesin occupancy correlates with transcriptional activity of key developmental genes. The compact sperm genome contains compartments with actively transcribed genes but no fine-scale topological domains, concomitant with the presence of protamines. Overall, we demonstrate how genome-wide cohesin occupancy and transcriptional activity is associated with three-dimensional (3D) remodeling during spermatogenesis, ultimately reprogramming the genome for the next generation

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)