335 research outputs found
From amines to (form)amides: a simple and successful mechanochemical approach
Two easily accessible routes for preparing an array of formylated and acetylated amines under mechanochemical conditions are presented. The two methodologies exhibit complementary features as they enable the derivatization of aliphatic and aromatic amines
STZ-diabetic rat heart maintains developed tension amplitude by increasing sarcomere length and crossbridge density
New Findings: What is the central question of this study? In the papillary muscle from type I diabetic rats, does diabetes-associated altered ventricular function result from changes of acto-myosin interactions and are these modifications attributable to a possible sarcomere rearrangement? What is the main finding and its importance? For the first time, we showed that type-I diabetes altered sarcomeric ultrastructure, as seen by transmission electron microscopy, consistent with physiological parameters. The diabetic condition induced slower timing parameters, which is compatible with a diastolic dysfunction. At the sarcomeric level, augmented β-myosin heavy chain content and increased sarcomere length and crossbridges' number preserve myocardial stroke and could concur to maintain the ejection fraction. Abstract: We investigated whether diabetes-associated altered ventricular function, in a type I diabetes animal model, results from a modification of acto-myosin interactions, through the in vitro recording of left papillary muscle mechanical parameters and examination of sarcomere morphology by transmission electron microscopy (TEM). Experiments were performed on streptozotocin-induced diabetic and age-matched control female Wistar rats. Mechanical isometric and isotonic indexes and timing parameters were determined. Using Huxley's equations, we calculated mechanics, kinetics and energetics of myosin crossbridges. Sarcomere length and A-band length were measured on TEM images. Type I and III collagen and β-myosin heavy chain (MHC) expression were determined by immunoblotting. No variation in resting and developed tension or maximum extent of shortening was evident between groups, but diabetic rats showed lower maximum shortening velocity and prolonged timing parameters. Compared to controls, diabetics also displayed a higher number of crossbridges with lower unitary force. Moreover, no change in type I and III collagen was associated to diabetes, but pathological rats showed a two-fold enhancement of β-MHC content and longer sarcomeres and A-band, detected by ultrastructural morphometry. Overall, these data address whether a preserved systolic function accompanied by an altered diastolic phase results from a recruitment of super-relaxed myosin heads or the phosphorylation of the regulatory light chain site in myosin. Although the early signs of diabetic cardiomyopathy were well expressed, the striking finding of our study was that, in diabetics, sarcomere modification may be a possible compensatory mechanism that preserves systolic function
Numerical analysis of a latent heat thermal energy storage system under partial load operating conditions
One of the features that should be considered when designing a thermal energy storage (TES) system is its behaviour when subjected to non-continuous (partial loads) operating conditions. Indeed, the system performance can be sensibly affected by the partial charging and discharging processes. This topic is analysed in the present study by means of a two-dimensional axisymmetric numerical model implemented in COMSOL Multiphysics. A latent heat TES system consisting of a vertical concentric tube heat exchanger is simulated to investigate the effect of different partial load operating conditions on the system behaviour. The effects of different heat transfer distributions and evolutions of the solid-liquid interface, are evaluated to identify the optimal management criteria of the TES systems. The results showed that partial load strategies allow to achieve a substantial reduction in the duration of the TES (up to 50%) process against a small decrease in stored energy (up 30%). The close correlation between the energy and the duration of the TES cycle is also evaluated during the discharge using detailed maps related to the melting fraction. These maps allow for the evaluation of the most efficient load conditions considering both charging and discharging processes to satisfy a specific energy demand.Simone Arena and Efisio Casti would like to thank the Department of Mechanical, Chemical and Materials Engineering of the University of Cagliari for their founding research grants. The work was partially funded by the Spanish government (ENE2015-64117-C5-1-R (MINECO/FEDER)). The authors would like to thank the Catalan Government for the quality accreditation given to their research group (2014 SGR 123). GREA is certified agent TECNIO in the category of technology developers from the Government of Catalonia. Jaume Gasia would like to thank the Departament d'Universitats, Recerca i Societat de la InformaciĂł de la Generalitat de Catalunya for his research fellowship (2017 FI_B1 00092)
Numerical simulation of a finned-tube LHTES system: influence of the mushy zone constant on the phase change behaviour
This work presents a numerical investigation on latent heat thermal energy storage (LHTES) systems during the phase change process. The numerical analysis, based on the apparent heat capacity formulation, was carried out through a two-dimensional axisymmetric numerical model developed by means of the COMSOL Multiphysics software. A thermal energy storage system based on the configuration of a double tube heat exchanger with finned surfaces was used as an experimental test case and the commercial paraffin RT35 was selected as phase change material (PCM). The influence of the heat transfer by convection, in particular the influence of the term describing the mushy zone in the momentum equation, was investigated during the whole charge and discharge processes. Three different values of the constant Amush, equals to 104, 106 and 108 were selected as well as two different values of the HTF volumetric flow rate were adopted in order to reproduce both laminar and turbulent flow regimes. The results are reported in terms of temperature, melting fraction and phases evolution during the whole melting and solidification processes, and compared to previous experimental tests carried out in the laboratories of the University of Lleida, Spain. A good agreement with the experimental results was obtained showing that the mushy zone constant has a significant influence on the interface shape and motion. The results show that large values of Amush determine an increase of the mushy region reducing the natural convection effects during the charge phase. Thus, the proper evaluation of the mushy zone constant allows providing a deeper understanding of the phase change behaviour, resulting in an important parameter for accurate modelling of LHTES systems.The work was partially funded by the Spanish government (ENE2015-64117-C5-1-R (MINECO/FEDER)). Jaume
Gasia and Prof. Luisa F. Cabeza would like to thank the Catalan Government for the quality accreditation given to
their research group (2014 SGR 123). GREA is certified agent TECNIO in the category of technology developers
from the Government of Catalonia. This project has received funding from the European Commission Seventh
Framework Programme (FP/2007-2013) under Grant agreement NÂş PIRSES-GA-2013-610692 (INNOSTORAGE)
and from the European Union’s Horizon 2020 research and innovation programme under grant agreement No
657466 (INPATH-TES). Jaume Gasia would like to thank the Departament d'Universitats, Recerca i Societat de la
InformaciĂł de la Generalitat de Catalunya for his research fellowship (2017 FI_B1 00092)
Multi-Agent Complex Systems and Many-Body Physics
Multi-agent complex systems comprising populations of decision-making
particles, have many potential applications across the biological,
informational and social sciences. We show that the time-averaged dynamics in
such systems bear a striking resemblance to conventional many-body physics. For
the specific example of the Minority Game, this analogy enables us to obtain
analytic expressions which are in excellent agreement with numerical
simulations.Comment: Accepted for publication in Europhysics Letter
Experimental and numerical research activity on a packed bed TES system
This paper presents the results of experimental and numerical research activities on a packed bed sensible thermal energy storage (TES) system. The TES consists of a cylindrical steel tank filled with small alumina beads and crossed by air used as the heat transfer fluid. Experimental tests were carried out hile varying some operating parameters such as the mass flow rate, the inlet–outlet temperature thresholds and the aspect ratio (length over diameter). Numerical simulations were carried out using a one-dimensional model, specifically developed in the Matlab-Simulink environment and a 2D axisymmetric model based on the ANSYS-Fluent platform. Both models are based on a two-equation transient approach to calculate fluid and solid phase temperatures. Thermodynamic properties were considered to be temperature-dependent and, in the Computational Fluid Dynamics (CFD) model, variable porosity of the bed in the radial direction, thermal losses and the effective conductivity of the alumina beads were also considered. The simulation results of both models were compared to the experimental ones, showing good agreement. The one-dimensional model has the advantage of predicting the axial temperature distribution with a very low computational cost, but it does not allow calculation of the correct energy stored when the temperature distribution is strongly influenced by the wall. To overcome this problem a 2D CFD model was used in this work
SHELF-LIFE OF HALAL FRESH SLICED BEEF AND MINCED MEAT
Microbiological and chemical-physical characterization of Halal beef fresh and minced meat, vacuum-packaged and stored at +2°C and +8°C, were examined, at 0, 7, 14 and 21 days, to evaluate the shelf-life. Lactic Acid Bacteria and Coliforms were higher in samples stored at +8 °C, particularly in minced meat. Pseudomonas were the most prevalent flora in all the products, and the contamination level, above 4 log10 cfu/g, were reached at 7 days in all the samples and was maintained during the study. The shelf-life can be extended reducing the storage temperature (< +2°C), and improving the packaging conditions
Towards Autopoietic Computing
A key challenge in modern computing is to develop systems that address
complex, dynamic problems in a scalable and efficient way, because the
increasing complexity of software makes designing and maintaining efficient and
flexible systems increasingly difficult. Biological systems are thought to
possess robust, scalable processing paradigms that can automatically manage
complex, dynamic problem spaces, possessing several properties that may be
useful in computer systems. The biological properties of self-organisation,
self-replication, self-management, and scalability are addressed in an
interesting way by autopoiesis, a descriptive theory of the cell founded on the
concept of a system's circular organisation to define its boundary with its
environment. In this paper, therefore, we review the main concepts of
autopoiesis and then discuss how they could be related to fundamental concepts
and theories of computation. The paper is conceptual in nature and the emphasis
is on the review of other people's work in this area as part of a longer-term
strategy to develop a formal theory of autopoietic computing.Comment: 10 Pages, 3 figure
Detection of Solar Coronal Mass Ejections from Raw Images with Deep Convolutional Neural Networks
Coronal Mass Ejections (CMEs) are massive releases of plasma from the solar corona. When the charged material is ejected towards the Earth, it can cause geomagnetic storms and severely damage electronic equipment and power grids. Early detection of CMEs is therefore crucial for damage containment. In this paper, we study detection of CMEs from sequential images of the solar corona acquired by a satellite. A low-complexity deep neural network is trained to process the raw images, ideally directly on the satellite, in order to provide early alerts
The Heliospheric Space Weather Center: A novel space weather service
The Heliospheric Space Weather Center project is the result of the synergy between the Aerospace Logistics Technology Engineering Company (ALTEC S.p.A.) and the INAF-Astrophysical Observatory of Torino, both located in Turin, Italy. The main goal of this project is to provide space weather medium and short-term forecast, by combining remote-sensing and in situ open data with novel data analysis technologies, giving to scientists the possibility of designing, implementing, and validating space-weather algorithms using extensive data sets
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