Algunas consideraciones sobre los alcances y limitaciones metodológicas del cuerpo conceptual marxista para explicar el voto popular en las elecciones presidenciales 2015 en Argentina

El presente trabajo tiene como objetivo contribuir a la discusión sobre las limitaciones que se presentan para poder comprender la coyuntura política actual, utilizando como disparador una reflexión hipotética sobre las condiciones de posibilidad del análisis de las últimas elecciones presidenciales argentinas de noviembre de 2015. En particular reflexionaremos a partir de algunos conceptos teóricos desarrollados por el marxismo heterodoxo. La situación sociopolítica actual que advierte el avance del neoliberalismo en Latinoamérica, en cada formación social con su especificidad, impone a la agenda de las ciencias sociales la necesidad de discutir de qué modo y con cuáles herramientas metodológicas podríamos obtener hoy la materia prima que nos permita dar cuenta de la especificidad de las formaciones sociales concretas, de modo tal, de alimentar los conceptos mediante los cuales pretendemos reflexionar sobre ellas. Nuestra reflexión está encuadrada dentro de las categorías del cuerpo conceptual althusseriano como así también de los aportes centrales con los que N. Poulantzas contribuye a la teoría del Estado en el marxismo, sin dejar de lado a intelectuales ineludibles de la región como A. García Linera, en tanto rescata la importancia de Poulantzas para pensar los procesos políticos en las periferias.Fil: Castagnolo, Héctor D.. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y SocialesFil: Gelman, Mariela. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociale

Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria

A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid

Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure‐based virtual screening approach using the ZIKV NS5‐MTase. A novel series of molecules with a carbazoyl‐aryl‐urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23–48 μM. In addition, carbazoyl‐aryl‐ureas also proved to inhibit ZIKV replication activity at micromolar concentration

The ALTCRISS project on board the International Space Station

The Altcriss project aims to perform a long term survey of the radiation environment on board the International Space Station. Measurements are being performed with active and passive devices in different locations and orientations of the Russian segment of the station. The goal is to perform a detailed evaluation of the differences in particle fluence and nuclear composition due to different shielding material and attitude of the station. The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also placed in the same location of Sileye-3 detector. Polyethylene shielding is periodically interposed in front of the detectors to evaluate the effectiveness of shielding on the nuclear component of the cosmic radiation. The project was submitted to ESA in reply to the AO in the Life and Physical Science of 2004 and data taking began in December 2005. Dosimeters and data cards are rotated every six months: up to now three launches of dosimeters and data cards have been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research http://dx.doi.org/10.1016/j.asr.2007.04.03

Flight results on Marangoni flow instability in liquid bridges

This paper reports on the results of the experiment PULSAR (Pulsating and Rotating Instabilities in Oscillatory Marangoni Flows), performed on the MAXUS 3 Sounding Rocket launched last November from the Swedish base in Kiruna. Aim of the experiment was the study of the oscillatory Marangoni convection in a cylindrical liquid bridge of silicone oil with kinematic viscosity of 5cSt. The experiment was motivated by preliminary on-ground numerical simulations and microscale experimental studies, that have pointed out that the oscillatory Marangoni instability appears at the beginning in the form of a pulsating regime, caused by a hydro-thermal standing wave, and then it turns to a rotating regime, caused by a traveling wave. The height of the bridge was equal to the disk diameter (20mm), and the imposed temperature difference was 15K during the first 460 s and 20K in the second part of the experiment, until the end of the microgravity period. The analysis of the temperature profiles, measured by thermocouples located near the disks at the same radial and axial coordinate but at different azimuthal coordinates (shifted at 90°), and the surface temperature distribution, measured by an infrared thermocamera, show that a pulsating and a mixed pulsating-rotating regimes have been established during the experiment. Unfortunately during the flight the accelerations level caused by two centrifuges with some biological samples in an adjacent module were above the expected values, so that disturbing g-jitter were encountered at different times during the microgravity mission. The effecst are clearly visible and the numerical simulations had to make different assumptions to correlate the experimental results

Assessing the impact of partitioning on optimal installation of control valves for leakage minimization in WDNs

This paper aims to assess the impact of partitioning on optimal installation of control valves for leakage minimization in water distribution networks (WDNs). The methodology used includes two main elements. The first element is a deterministic algorithm operating through the sequential addition of control valves, producing a Pareto front of optimal solutions in the trade-off between number of control valves installed and daily leakage volume, to be both minimized. The second element is a WDN partitioning algorithm based on the minimization of the transport function, for the partitioning of the WDN into a number of partitions equal to the number of WDN sources. The methodology is applied to two Italian WDNs with different characteristics. Due to variations in flow distribution induced by the partitioning, the valve locations optimally selected in the partitioned WDN prove slightly different from those in the unpartitioned WDN. Furthermore, the number of control valves being the same, better leakage reduction effects (up to 8%) are obtained in the partitioned WDN

Enantioselective synthesis of 1-aryl-2-propenylamines: a new approach to a stereoselective synthesis of the Taxol® side chain.

A variety of substituted 1-aryl-2-propenylamines of high enantiomeric purity were prepared via lipase-catalysed resolution of the corresponding racemates. (R)-1-Phenyl-2-propenylamine was further synthesised into (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoic acid methyl ester, the side chain of Taxol®