Carga imediata em arcos totais para reabilitação com prótese fixa implanto-suportada: Revisão dos aspetos críticos para o sucesso

Introdução: A carga imediata de implantes dentários para arcos totais nos pacientes edêntulos representa um tratamento com incríveis benefícios psicológicos e de satisfação para o paciente, com taxas de sucesso comparáveis a os outros protocolos de carga implantar (antecipada e diferida). Objetivo: Revisar a literatura e definir os diferentes protocolos de carga imediata em arcadas totais, a fim de estabelecer diretrizes previsíveis para o sucesso clínico em longo prazo. Materiais e métodos: Pesquisa bibliográfica realizada na plataforma eletrónica PUBMED. Diferentes combinações de palavras-chave foram usadas: ((immediate implant) AND (full arch) AND (complete arch) AND (fixed prosthesis)) OR (all-on). Foram selecionados 28 artigos, respeitando os critérios de inclusão e exclusão propostos. Resultados: Um bom resultado pode ser esperado se critérios adequados forem utilizados na avaliação do paciente, na escolha da configuração implantar e na realização do tratamento cirúrgico e protético. Altas taxas de sobrevivência de implantes e das reabilitações, e uma baixa perda óssea marginal são relatadas. Conclusões: A carga imediata em reabilitações totais implanto-suportadas oferece vantagens funcionais e estéticas, melhorando a qualidade de vida do paciente durante o período de osteointegração do implante. No osso maxilar, a disponibilidade na área pré-maxilar e pré-molar é necessária para obter distribuição ântero-posterior suficiente dos implantes e reduzir o comprimento do cantilever. No osso mandibular, a posição/trajetória do nervo alveolar inferior e a quantidade de osso vertical atrás do canal mentoniano ditarão a técnica mais apropriada. A técnica all-on-four é uma opção viável para os dois maxilares, com taxas de sucesso extremamente favoráveis

Skin contamination as pathway for nicotine intoxication in vapers

Growing warnings on health effects related to electronic cigarettes have met inconclusive findings at present. This study analyzed the in vitro percutaneous absorption of nicotine resulting by skin contamination with two e-liquids (refill 1 and 2) containing nicotine at 1.8%. Donor chambers of 6 Franz cells for each refill liquid were filled with 1 mL of nicotine e-liquid for 24 h; at selected intervals, 1.5 mL of the receptor solutions were collected for nicotine concentration analysis by mean gas chromatography\u2013mass spectrometry (LOD: 0.01 \u3bcg/mL). The experiment was repeated removing the nicotine donor solution after 10 min from the application and rinsing the skin surface three times with 3.0 mL of milliQ water. A total of 12 cells with 24 h exposure and 12 cells washed were studied. The mean concentration of nicotine in the receiving phase at the end of the experiment was 54.9 \ub1 29.5 and 30.2 \ub1 18.4 \u3bcg/cm2 for refill 1 and 2 respectively and significantly lower in washed cells (4.7 \ub1 2.4 and 3.5 \ub1 1.3 \u3bcg/cm2). The skin absorption of nicotine can lead to minor health illness in vapers, while caution must be paid to dermal contamination by e liquids in children. The skin cleaning significantly reduced the transdermal absorption kinetic and intradermal deposition of nicotine

Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target.

We reported that the clinical efficacy of dendritic cell-based vaccination is strongly associated with immunologic responses in relapsed B-cell non-Hodgkin lymphoma (B-NHL) patients. We have now investigated whether postvaccination antibodies from responders recognize novel shared NHL-restricted antigens. Immunohistochemistry and flow cytometry showed that they cross-react with allogeneic B-NHLs at significantly higher levels than their matched prevaccination samples or nonresponders' antibodies. Western blot analysis of DOHH-2 lymphoma proteome revealed a sharp band migrating at approximately 100 to 110 kDa only with postvaccine repertoires from responders. Mass spectrometry identified heat shock protein-105 (HSP105) in that molecular weight interval. Flow cytometry and immunohistochemistry disclosed HSP105 on the cell membrane and in the cytoplasm of B-NHL cell lines and 97 diagnostic specimens. A direct correlation between HSP105 expression and lymphoma aggressiveness was also apparent. Treatment of aggressive human B-NHL cell lines with an anti-HSP105 antibody had no direct effects on cell cycle or apoptosis but significantly reduced the tumor burden in xenotransplanted immunodeficient mice. In vivo antilymphoma activity of HSP105 engagement was associated with a significant local increase of Granzyme B(+) killer cells that very likely contributed to the tumor-restricted necrosis. Our study adds HSP105 to the list of nononcogenes that can be exploited as antilymphoma targets

The cosmic ray primary composition in the "knee" region through the EAS electromagnetic and muon measurements at EAS-TOP

Abstract The evolution of the cosmic ray primary composition in the energy range 10 6 –10 7 GeV (i.e. the "knee" region) is studied by means of the e.m. and muon data of the Extensive Air Shower EAS-TOP array (Campo Imperatore, National Gran Sasso Laboratories). The measurement is performed through: (a) the correlated muon number ( N μ ) and shower size ( N e ) spectra, and (b) the evolution of the average muon numbers and their distributions as a function of the shower size. From analysis (a) the dominance of helium primaries at the knee, and therefore the possibility that the knee itself is due to a break in their energy spectrum (at E k He =(3.5±0.3)×10 6 GeV) are deduced. Concerning analysis (b), the measurement accuracies allow the classification in terms of three mass groups: light (p,He), intermediate (CNO), and heavy (Fe). At primary energies E 0 ≈10 6 GeV the results are consistent with the extrapolations of the data from direct experiments. In the knee region the obtained evolution of the energy spectra leads to: (i) an average steep spectrum of the light mass group ( γ p,He >3.1), (ii) a spectrum of the intermediate mass group harder than the one of the light component ( γ CNO ≃2.75, possibly bending at E k CNO ≈(6–7)×10 6 GeV), (iii) a constant slope for the spectrum of the heavy primaries ( γ Fe ≃2.3–2.7) consistent with the direct measurements. In the investigated energy range, the average primary mass increases from 〈ln A 〉=1.6–1.9 at E 0 ≃1.5×10 6 GeV to 〈ln A 〉=2.8–3.1 at E 0 ≃1.5×10 7 GeV. The result supports the standard acceleration and propagation models of galactic cosmic rays that predict rigidity dependent cut-offs for the primary spectra of the different nuclei. The uncertainties connected to the hadronic interaction model (QGSJET in CORSIKA) used for the interpretation are discussed

Toxicity of some insecticides to Tetranychus urticae, Neoseiulus californicus and Tydeus californicus

The spider mite Tetranychus urticae, the predatory mite Neoseiulus californicus and the unspecialised feeder Tydeus californicus are frequently encountered on vegetables. The direct and residual effects of six insecticides recommended for the control of aphids, whiteflies and thrips in vegetable crops were evaluated on these mite species in the laboratory. Pesticide effects was often favourable towards T. urticae and unfavourable towards N. californicus and T. californicus. Rotenone was more toxic to eggs than females of T. urticae, and was highly toxic to N. californicus and T. californicus. Pyrethrins and imidacloprid increased T. urticae fecundity but decreased fecundity of N. californicus. Beauveria bassiana was not toxic to T. urticae and T. californicus, but induced high mortality in the progeny of N. californicus. Azadirachtin and pymetrozine were the least toxic to T. urticae and N. californicus, but affected T. californicus progeny. Implications of this study for IPM tactics are discussed

The impact of eriophyoids on crops: recent issues on Aculus schlechtendali, Calepitrimerus vitis and Aculops lycopersici.

The nature of the damage caused by eriophyoid mites and the assessment of yield losses still require detailed studies. Three eriophyoid mites frequently reported in recent research are here considered: the apple rust mite, Aculus schlechtendali and the grape rust mite, Calepitrimerus vitis colonise temperate fruits, while Aculops lycopersici affects vegetables. The damage assessment related to the apple rust mite has been evaluated on different apple varieties. Some factors affecting the spread and economic importance of the grape rust mite have been discussed. The difficulty in controlling the tomato russet mite by chemicals enhances the interest in biological control agents