Using Dynamic Neural Networks for Battery State of Charge Estimation in Electric Vehicles

Due to urban pollution, transport electrification is being currently promoted in different countries. Electric Vehicles (EVs) sales are growing all over the world, but there are still some challenges to be solved before a mass adoption of this type of vehicles occurs. One of the main drawbacks of EVs are their limited range, for that reason an accurate estimation of the state-of-charge (SOC) is required. The main contribution of this work is the design of a Nonlinear Autoregressive with External Input (NARX) artificial neural network to estimate the SOC of an EV using real data extracted from the car during its daily trips. The network is trained using voltage, current and four different battery pack temperatures as input and SOC as output. This network has been tested using 54 different real driving cycles, obtaining highly accurate results, with a mean squared error lower than 1e-6 in all situationsThis work has been partially financed by the Spanish Ministry of Economy and Competitiveness within the framework of the project DEMS: “Sistema distribuido de gestión de energía en redes eléctricas inteligentes (TEC2015-66126-R)"

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Impacto de las políticas de autoconsumo y recarga del vehículo eléctrico en comunidades energéticas

Autokontsumoa funtsezko tresna da energia berriztagarriak integratzeko eta energiaren sektorean kontsumitzaileen parte-hartze aktiboa sustatzeko. Horretarako, autokontsumoaren erregulazioa hedatu egin behar da, autokontsumo partekatua, komunitate energetikoak, biltegiratzea eta ibilgailu elektrikoak barne hartuz. Artikulu honetan autokontsumo partekatuko eta ibilgailu elektrikoaren kudeaketako hainbat politika aintzat hartzen dituen erkidego baten kostu energetikoa optimizatzeko arazo bat aurkezten da. Arazoa etxeko bost kontsumitzailek osatutako energia-komunitate bati aplikatzen zaio, ibilgailu elektrikoaren erabilerarako, lan-ordutegi eta eguneko kontsumo desberdinak dituztenean. Emaitzek erakusten dute inplikatutako politikek eragin handiagoa dutela komunitatearen prezioan ibilgailu elektrikoei emandako erabilerak baino.Self-consumption is a key element to integrate renewable energies and foster consumer participation in the energy sector. To expand it, self-consumption regulation needs to incorporate policies such as shared self-consumption, energy communities, storage and electric vehicles. In this article, an optimization problem for the total cost of an energy community considering different self-consumption and electric vehicle management policies is presented. The problem is applied to a set of electric vehicle usage scenarios with diverse work schedules and daily consumptions. Results show that the involved policies have a greater impact on the community’s energy cost than the usage of the electric vehicles.El autoconsumo es una herramienta fundamental para integrar energías renovables y fomentar la participación activa de los consumidores en el sector energético. Para ello, la regulación del autoconsumo debe expandirse, incorporando figuras como el autoconsumo compartido, las comunidades energéticas, el almacenamiento y los vehículos eléctricos. En este artículo se presenta un problema de optimización del coste energético de una comunidad que considera diferentes políticas de autoconsumo compartido y gestión del vehículo eléctrico. El problema se aplica a una comunidad de energía compuesta por cinco consumidores domésticos para escenarios de uso del vehículo eléctrico con diferentes horarios de trabajo y consumos diarios. Los resultados muestran que las políticas involucradas tienen mayor impacto en el precio de la comunidad que el uso dado a los vehículos eléctricos

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele