Intelligent recruitment: how to identify, select, and retain talents from around the world using artificial intelligence.

This research analyzes how digital technologies contribute to improving the successive stages of the recruitment process: identifying, selecting, and retaining talented people. E-recruitment is an emerging and polymorphous phenomenon that starts with identification of candidates on social networks, continues through gamification of recruitment and job interviews with chatbots, and ends by matching a candidate and a job using artificial intelligence. These technologies are particularly useful for social businesses looking to recruit not only skilled people, but above all employees who have behaviors and values that match their mission. The methodology is based on grounded theory, participant observation, and qualitative data collection. A multiple case study is designed to analyze, compare, and combine several technologies dedicated to recruitment: (1) a social network with LinkedIn, (2) a MOOC with Udacity, (3) a serious game called Reveal from L'Oréal, (4) a chatbot called Ari from TextRecruit, and (5) a massive data analysis matching system with Randstad.tech. The discussion examines the respective performance and limits of these tools and their convergence via a progressive integration that leads to an uberization of recruitment. Managerial recommendations are formulated to support recruiters in their adoption of e-recruitment

Why do sustainable mergers fail to manage entrepreneurship?

9 p.This paper proposes a conceptual model using four failed mergers (Federated -Fingerhut, KCPL and Western Resources, Daimler–Chrysler and Alcatel–Lucent) and distinguishes two types of dimensions: type of failure (tangible and intangible) and degree of failure (fixable and unfixable). Using case studies as a research strategy and focusing on the Alcatel–Lucent merger, as an example of an idiosyncratic type of “merger of equals”, the model identifies the entrepreneurial conflict variable as a missed step for obtaining a sustainable merger process over time

Mindfulness "effects on undergraduates" perception of self-knowledges and stress levels

In this study, mindfulness was applied in the university to help students reach a higher self-knowledge and reduce stress levels. The general goals are for students to identify their role in every situation and moment of their everyday routine and to teach them how to control their emotions, thus increasing their motivation and tolerance to frustration. The sample consisted of 64 students of Business Administration and International Business degrees. The method involved multiple sessions and exercises that took place for eight weeks. Using data from an initial questionnaire and a final, long-term questionnaire, this study assesses stress determinants. The conclusions indicate that participants' stress levels are up to 15% lower, and they feel more relaxed. Mindfulness is an additional tool for self-knowledge acquisition that increases motivation and enables analysis of the environment through a more objective viewpoint

Mindfulness as an entrepreneurship tool for improving the working environment and self-awareness

This paper presents how to implement a program with an Intrapreneurship methodology such as Mindfulness which develops the emotional intelligence. The objective is for workers to acquire role self-awareness using Mindfulness, and to improve the working environment. The results obtained after analysing quantitative variables are presented for a sample of 76 professionals working in nursing homes for the elderly after a Mindfulness and Emotional Management program for 8 weeks. The before and after step in the FFMQ questionnaire is used to examine how it acts as a measurement model for obtaining a report composed of 39 items, which measures the general tendency towards Mindfulness, based on five skills. The results show improvements in all the dimensions, and particularly in Observing, Acting with Self-Awareness and Nonjudging. In conclusion, the workers' social well-being improved after the program was implemented, thereby contributing to the improvement of their relationships with their colleagues

Developing management skills through experiential learning: the effectiveness of outdoor training and mindfulness

The primary goal of this study is to develop a tool to measure the personal and interpersonal skills of individuals who participate in experiential learning based on outdoor training and mindfulness sessions. This paper presents the results of an application of this method to a sample of 97 participants (49 employees and 48 master’s and undergraduate students). Using competency questionnaires, participants were evaluated by managers and tutors. Participants were assessed individually. The following competencies were analysed: teamwork, communication, leadership, motivation, stress tolerance, organisation and planning, responsibility, and analysis, resolution and anticipation of problems. The results show that students and employees require further development in terms of their leadership, teamwork, responsibility and stress tolerance. Teamwork should be promoted. Individuals should be encouraged to delegate and accept opinions, ideas and criticism from other team members. It is important to identify the leader and the followers. This requires all individuals to accept their roles and responsibilities by taking charge of their actions. For the sample of workers, the manager’s evaluations were consistently less positive than the evaluations by the workers themselves

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors

Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. Methods: Here, we systematically evaluated the expression levels (by quantitative-PCR) of key ghrelin system components of in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) and normal tissues (NT; n = 14). Then, we analyzed their putative associations with clinical-histological characteristics. Results: The results indicate that ghrelin and its receptor GHSR1a are present in a high proportion of normal tissues, while the enzyme ghrelin-O-acyltransferase (GOAT) and the splicing variants In1-ghrelin and GHSR1b were present in a lower proportion of normal tissues. In contrast, all ghrelin system components were present in a high proportion of tumor and NTA tissues. GOAT was significantly overexpressed (by quantitative-PCR (qPCR)) in tumor samples compared to NTA, while a trend was found for ghrelin, In1-ghrelin and GHSR1a. In addition, expression of these components displayed significant correlations with key clinical parameters. The marked overexpression of GOAT in tumor samples compared to NTA regions was confirmed by IHC, revealing that this enzyme is particularly overexpressed in gastrointestinal NETs, where it is directly correlated with tumor diameter. Conclusions: These results provide novel information on the presence and potential pathophysiological implications of the ghrelin system components in GEP-NETs, wherein GOAT might represent a novel diagnostic biomarker

Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer

Certain components of the somatostatin-system play relevant roles in Prostate Cancer (PCa), whose most aggressive phenotype (Castration-Resistant-PCa (CRPC)) remains lethal nowadays. However, neuronostatin and the G protein-coupled receptor 107 (GPR107), two novel members of the somatostatin-system, have not been explored yet in PCa. Consequently, we investigated the pathophysiological role of NST/GPR107-system in PCa. GPR107 expression was analyzed in well-characterized PCa patient′s cohorts, and functional/mechanistic assays were performed in response to GPR107-silencing and NST-treatment in PCa cells (androgen-dependent (AD: LNCaP) and androgen-independent (AI: 22Rv1/PC-3), which are cell models of hormone-sensitive and CRPC, respectively), and normal prostate cells (RWPE-1 cell-line). GPR107 was overexpressed in PCa and associated with key clinical parameters (e.g., advance stage of PCa, presence of vascular invasion and metastasis). Furthermore, GPR107-silencing inhibited proliferation/migration rates in AI-PCa-cells and altered key genes and oncogenic signaling-pathways involved in PCa aggressiveness (i.e., KI67/CDKN2D/MMP9/PRPF40A, SST5TMD4/AR-v7/In1-ghrelin/EZH2 splicing-variants and AKT-signaling). Interestingly, NST treatment inhibited proliferation/migration only in AI-PCa cells and evoked an identical molecular response than GPR107-silencing. Finally, NST decreased GPR107 expression exclusively in AI-PCa-cells, suggesting that part of the specific antitumor effects of NST could be mediated through a GPR107-downregulation. Altogether, NST/GPR107-system could represent a valuable diagnostic and prognostic tool and a promising novel therapeutic target for PCa and CRPC

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pathophysiological role in PCa. We analysed urine/plasma levels of GOAT in a cohort of 993 patients. In vitro (i.e., cell-proliferation) and in vivo (tumor-growth in a xenograft-model) approaches were performed in response to the modulation of GOAT expression/activity in PCa cells. Our results demonstrate that plasma and urine GOAT levels were significantly elevated in PCa patients compared to controls. Remarkably, GOAT significantly outperformed PSA in the diagnosis of PCa and significant PCa in patients with PSA levels ranging from 3 to 10 ng/mL (the so-called PSA grey-zone). Additionally, urine GOAT levels were associated to clinical (e.g., Gleason-score, PSA levels) and molecular (e.g., CDK2/CDK6/CDKN2A expression) aggressiveness parameters. Indeed, GOAT overexpression increased, while its silencing/blockade decreased cell-proliferation in PCa cells. Moreover, xenograft tumors derived from GOAT-overexpressing PCa (DU145) cells were significantly higher than those derived from the mock-overexpressing cells. Altogether, our results demonstrate that GOAT could be used as a diagnostic and aggressiveness marker in urine and a therapeutic target in PCa

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the expression/secretion profile of EN2 in five independent samples cohorts from PCa patients and controls (prostate tissues and/or urine) to determine its utility as a PCa biomarker; and 2) the functional role of EN2 in normal (RWPE1) and tumor (LNCaP/22Rv1/PC3) prostate cells to explore its potential value as therapeutic target. EN2 was overexpressed in our two cohorts of PCa tissues compared to control and in tumor cell lines compared with normal-like prostate cells. This profile was corroborated in silico in three independent data sets [The Cancer Genome Atlas(TCGA)/Memorial Sloan Kettering Cancer Center (MSKCC)/Grasso]. Consistently, urine EN2 levels were elevated and enabled discrimination between PCa and control patients. EN2 treatment increased cell proliferation in LNCaP/22Rv1/PC3 cells, migration in RWPE1/PC3 cells, and PSA secretion in LNCaP cells. These effects were associated, at least in the androgen-sensitive LNCaP cells, with increased AKT and androgen-receptor phosphorylation levels and with modulation of key cancer-associated genes. Consistently, EN2 treatment also regulated androgen-receptor activity (full-length and splicing variants) in androgen-sensitive 22Rv1 cells. Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa