Effect of turbulence on electron cyclotron current drive and heating in ITER

Non-linear local electromagnetic gyrokinetic turbulence simulations of the ITER standard scenario H-mode are presented for the q=3/2 and q=2 surfaces. The turbulent transport is examined in regions of velocity space characteristic of electrons heated by electron cyclotron waves. Electromagnetic fluctuations and sub-dominant micro-tearing modes are found to contribute significantly to the transport of the accelerated electrons, even though they have only a small impact on the transport of the bulk species. The particle diffusivity for resonant passing electrons is found to be less than 0.15 m^2/s, and their heat conductivity is found to be less than 2 m^2/s. Implications for the broadening of the current drive and energy deposition in ITER are discussed.Comment: Letter, 5 pages, 5 figures, for submission to Nuclear Fusio

Validation of gyrokinetic modelling of light impurity transport including rotation in ASDEX Upgrade

Upgraded spectroscopic hardware and an improved impurity concentration calculation allow accurate determination of boron density in the ASDEX Upgrade tokamak. A database of boron measurements is compared to quasilinear and nonlinear gyrokinetic simulations including Coriolis and centrifugal rotational effects over a range of H-mode plasma regimes. The peaking of the measured boron profiles shows a strong anti-correlation with the plasma rotation gradient, via a relationship explained and reproduced by the theory. It is demonstrated that the rotodiffusive impurity flux driven by the rotation gradient is required for the modelling to reproduce the hollow boron profiles at higher rotation gradients. The nonlinear simulations validate the quasilinear approach, and, with the addition of perpendicular flow shear, demonstrate that each symmetry breaking mechanism that causes momentum transport also couples to rotodiffusion. At lower rotation gradients, the parallel compressive convection is required to match the most peaked boron profiles. The sensitivities of both datasets to possible errors is investigated, and quantitative agreement is found within the estimated uncertainties. The approach used can be considered a template for mitigating uncertainty in quantitative comparisons between simulation and experiment.Comment: 19 pages, 11 figures, accepted in Nuclear Fusio

Expression of inducible heat shock proteins Hsp27 and Hsp70 in the visual pathway of rats subjected to various models of retinal ganglion cell injury

Inducible heat shock proteins (Hsps) are upregulated in the central nervous system in response to a wide variety of injuries. Surprisingly, however, no coherent picture has emerged regarding the magnitude, duration and cellular distribution of inducible Hsps in the visual system following injury to retinal ganglion cells (RGCs). The current study sought, therefore, to achieve the following two objectives. The first aim of this study was to systematically characterise the patterns of Hsp27 and -70 expression in the retina and optic nerve in four discrete models of retinal ganglion cell (RGC) degeneration: axonal injury (ON crush), somato-dendritic injury (NMDA-induced excitotoxicity), chronic hypoperfusion (bilateral occlusion of the carotid arteris) and experimental glaucoma. The second aim was to document Hsp27 and -70 expression in the optic tract, the subcortical retinorecipient areas of the brain, and the visual cortex during Wallerian degeneration of RGC axons. Hsp27 was robustly upregulated in the retina in each injury paradigm, with the chronic models, 2VO and experimental glaucoma, displaying a more persistent Hsp27 transcriptional response than the acute models. Hsp27 expression was always associated with astrocytes and with a subset of RGCs in each of the models excluding NMDA. Hsp27 was present within astrocytes of the optic nerve/optic tract in control rats. During Wallerian degeneration, Hsp27 was upregulated in the optic nerve/optic tract and expressed de novo by astrocytes in the lateral geniculate nucleus and the stratum opticum of the superior colliculus. Conversely, the results of our study indicate Hsp70 was minimally induced in any of the models of injury, either in the retina, or in the optic nerve/optic tract, or in the subcortical, retinorecipient areas of the brain. The findings of the present study augment our understanding of the involvement of Hsp27 and Hsp70 in the response of the visual system to RGC degeneration.Glyn Chidlow, John P. M. Wood, Robert J. Casso

Topological quantum D-branes and wild embeddings from exotic smooth R^4

This is the next step of uncovering the relation between string theory and exotic smooth R^4. Exotic smoothness of R^4 is correlated with D6 brane charges in IIA string theory. We construct wild embeddings of spheres and relate them to a class of topological quantum Dp-branes as well to KK theory. These branes emerge when there are non-trivial NS-NS H-fluxes where the topological classes are determined by wild embeddings S^2 -> S^3. Then wild embeddings of higher dimensional $p$-complexes into S^n correspond to Dp-branes. These wild embeddings as constructed by using gropes are basic objects to understand exotic smoothness as well Casson handles. Next we build C*-algebras corresponding to the embeddings. Finally we consider topological quantum D-branes as those which emerge from wild embeddings in question. We construct an action for these quantum D-branes and show that the classical limit agrees with the Born-Infeld action such that flat branes = usual embeddings.Comment: 18 pages, 1 figur

Equivariant comparison of quantum homogeneous spaces

We prove the deformation invariance of the quantum homogeneous spaces of the q-deformation of simply connected simple compact Lie groups over the Poisson-Lie quantum subgroups, in the equivariant KK-theory with respect to the translation action by maximal tori. This extends a result of Neshveyev-Tuset to the equivariant setting. As applications, we prove the ring isomorphism of the K-group of Gq with respect to the coproduct of C(Gq), and an analogue of the Borsuk-Ulam theorem for quantum spheres.Comment: 21 page

Religious education for spiritual bricoleurs? the perceptions of students in ten Christian-ethos secondary schools in England and Wales

Religious Education (RE) in England and Wales functions within a post-secular culture. In the last fifty years, approaches characterised by academic rigour, impartiality, and professionalism have been prioritised. In this post-secular culture, the notion of bricolage aptly describes how some young people seek meaning, explore the spiritual dimension of life, with fragmented understandings of, experiences and encounters with the religious traditions. This paper draws on data from an empirical research project involving 350 students, to explore why students in ten Christian-ethos secondary schools in England and Wales recognised Religious Education (RE) as a significant contributor to their spiritual development. The analysis is illuminated by employing Roebben's (2009) concept of a narthical learning space (NLS) as the lens with which to examine young people’s experiences. Three aspects of RE are explored: the debating of existential questions; opportunities to theologise and reflect; and encounters with the beliefs, practices, and opinions of others. This article argues that the concept of RE as a narthical learning space alongside the notion of young people as spiritual bricoleurs illuminates how the students in this study interpret the contribution of RE to their spiritual development

Distribution and activity of mitochondrial proteins in vascular and avascular retinas: implications for retinal metabolism

Purpose:Understanding the energetics of retinal neurons and glia is crucial for developing therapies for diseases that feature deficits in nutrient or oxygen availability. Herein, we performed a detailed characterization of the distribution and activity of mitochondrial proteins in the vascularized retinas of rat and marmoset, and the avascular retinas of rabbit and guinea pig. Further, we delineated expression of ubiquitous mitochondrial creatine kinase (uMtCK). Methods:Expression of eight mitochondrial proteins was investigated using Western blotting, single- and double-labeling immunohistochemistry. Activities of cytochrome c oxidase, succinate dehydrgogenase, and isocitrate dehydrogenase were determined by enzyme histochemistry using unfixed tissue sections. Results:In vascularized retinas, immunoreactivities were characterized by strong, punctate labeling in the plexiform layers, photoreceptor inner segments, somas of various cell types, notably retinal ganglion cells (RGCs), and the basolateral surface of the retinal pigment epithelium. In avascular retinas, immunoreactivities featured intense labeling of inner segments, together with weak, but unambiguous, staining of both plexiform layers. RGCs were relatively enriched. In Müller cells of avascular retinas, mitochondria were restricted to scleral-end processes. For each species, enzyme activity assays yielded similar results to the protein distributions. Labeling for uMtCK in vascular and avascular retinas was fundamentally similar, being restricted to neuronal populations, most notably inner segments and RGCs. Of all of the mitochondrial proteins, uMtCK displayed the strongest labeling in avascular retinas. uMtCK was not detectable in Müller cells in any species. Conclusions:The current findings advance our understanding of the metabolic similarities and differences between vascular and avascular retinas.Glyn Chidlow, John P. M. Wood, Paul I. Sia, Robert J. Casso

Definition of glaucoma: clinical and experimental concepts

Glaucoma is a term describing a group of ocular disorders with multi-factorial etiology united by a clinically characteristic intraocular pressure-associated optic neuropathy. It is not a single entity and is sometimes referred to in the plural as the glaucomas. All forms are potentially progressive and can lead to blindness. The diverse conditions that comprise glaucoma are united by a clinically characteristic optic neuropathy: glaucomatous optic neuropathy (GON). Evidence suggests that the primary site of neurological injury is at the optic nerve head. This fact enables the conditions to be grouped, irrespective of the causal mechanism(s). The term experimental glaucoma implies model resemblance to the human condition. We propose that 'experimental glaucoma' be restricted to animal models with demonstrable features of GON and/or evidence of a primary axonopathy at the optic nerve head. A fundamental inadequacy in this framework is any reference to the pathogenesis of GON, which remains unclear.Robert J Casson, Glyn Chidlow, John PM Wood, Jonathan G Crowston, and Ivan Goldber

Performance of Large-Volume Mean-Timed Neutron Counters

This work was supported by the National Science Foundation Grant NSF PHY 78-22774 A02 & A03 and by Indiana Universit