Coupled rotor/airframe vibration analysis program manual manual. Volume 1: User's and programmer's instructions

user instruction and software descriptions for the base program of the coupled rotor/airframe vibration analysis are provided. The functional capabilities and procedures for running the program are provided. Interfaces with external programs are discussed. The procedure of synthesizing a dynamic system and the various solution methods are described. Input data and output results are presented. Detailed information is provided on the program structure. Sample test case results for five representative dynamic configurations are provided and discussed. System response are plotted to demonstrate the plots capabilities available. Instructions to install and execute SIMVIB on the CDC computer system are provided

Coupled rotor/airframe vibration analysis

A coupled rotor/airframe vibration analysis developed as a design tool for predicting helicopter vibrations and a research tool to quantify the effects of structural properties, aerodynamic interactions, and vibration reduction devices on vehicle vibration levels is described. The analysis consists of a base program utilizing an impedance matching technique to represent the coupled rotor/airframe dynamics of the system supported by inputs from several external programs supplying sophisticated rotor and airframe aerodynamic and structural dynamic representation. The theoretical background, computer program capabilities and limited correlation results are presented in this report. Correlation results using scale model wind tunnel results show that the analysis can adequately predict trends of vibration variations with airspeed and higher harmonic control effects. Predictions of absolute values of vibration levels were found to be very sensitive to modal characteristics and results were not representative of measured values

Clinical outcome of latissimus dorsi tendon transfer and partial cuff repair in irreparable postero-superior rotator cuff tear

Background and purpose Irreparable rotator cuff tears are a common cause of pain in adult population, requiring in many cases a surgical treatment. Possible alternatives are debridement, partial repair, muscle transfers and joint replacement. We evaluated two groups of patients with irreparable rotator cuff tear treated surgically: one group received an arthroscopic-assisted latissimus dorsi tendon transfer (LDTT), and the other an arthroscopic rotator cuff partial repair. Aim of our study was to compare clinical results and quality of life in two groups of patients with massive irreparable rotator cuff tear: one receiving an arthroscopic LDTT and the other receiving an arthroscopic rotator cuff partial repair. Methods Forty patients were assigned to two groups: 20 patients to group TT treated with LDTT and 20 patients to group PR treated with a partial repair. The average follow-up duration was 2.8 years (1\u20135, SD 3). Pre- and postoperative modified UCLA shoulder score, ROM, measurement of the strength and the rotator cuff quality of life (RC-QOL) were used to asses the outcome. Results LDTT showed significative improvements when compared to partial repair in UCLA score results, strength and RC-QOL questionnaire. No differences were found between the groups in pain relief. Conclusion Both techniques are effective in reducing patients\u2019 symptoms. We believe that in younger, high-demanding patients with no or mild osteoarthritis, the LDTT represents a valid treatment option with better modified UCLA score improvement and strength at our follow-up

Envisioning happy places for all : a systematic review of the impact of transformations in the urban environment on the wellbeing of vulnerable groups

Urban planning and design can impact mental health, but it is unclear how ever-growing and changing cities can sustain the psychological wellbeing of vulnerable groups, who are among the most mentally sensitive to spatial inequalities. This systematic review synthesised quantitative and qualitative studies on urban design interventions and their impact on wellbeing in vulnerable groups. Using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, we searched five online databases from inception to May 2020. A total of 10 papers were included. We found mixed evidence of benefits for wellbeing linked to urban regeneration projects or focused interventions (green spaces, transport, security). Interventions that were centred around participation, sustainable living, and quality of design (e.g., perceived sense of safety) were associated with increased residential satisfaction and wellbeing, particularly among low-income communities and women. Risk of bias was low to medium, but there was high methodological heterogeneity; studies were mainly from Western countries, and none of the included studies investigated the experiences of people with disabilities, migrants, or racial minorities. This review highlights the importance of inclusive and sustainable design interventions to create happy places for all strata of society, although further investigation is warranted

Coupled rotor/airframe vibration analysis program manual. Volume 2: Sample input and output listings

Sample input and output listings obtained with the base program (SIMVIB) of the coupled rotor/airframe vibration analysis and the external programs, G400/F389 and E927 are presented. Results for five of the base program test cases are shown. They represent different applications of the SIMVIB program to study the vibration characteristics of various dynamic configurations. Input and output listings obtained for one cycle of the G400/F389 coupled program are presented. Results from the rotor aeroelastic analysis E927 also appear. A brief description of the check cases is provided. A summary of the check cases for all the external programs interacting with the SIMVIB program is illustrated

Up-Regulated Dicer Expression in Patients with Cutaneous Melanoma

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (18-24 nucleotides) that have recently been shown to regulate gene expression during cancer progression. Dicer, a central enzyme in the multi-component miRNA biogenesis pathway, is involved in cutting precursor miRNAs to functionally mature forms. Emerging evidence shows that Dicer expression is deregulated in some human malignancies and it correlates with tumor progression, yet this role has not yet been investigated in skin cancers. METHODS AND FINDINGS: Using an anti-human monoclonal antibody against Dicer and immunohistochemistry, we compared the expression of Dicer protein among 404 clinically annotated controls and skin tumors consisting of melanocytic nevi (n = 71), a variety of melanomas (n = 223), carcinomas (n = 73) and sarcomas (n = 12). Results showed a cell-specific up-regulated Dicer in 81% of cutaneous, 80% of acrolentiginous and 96% of metastatic melanoma specimens compared to carcinoma or sarcoma specimens (P<0.0001). The expression of Dicer was significantly higher in melanomas compared to benign melanocytic nevi (P<0.0001). In patients with cutaneous melanomas, Dicer up-regulation was found to be significantly associated with an increased tumor mitotic index (P = 0.04), Breslow's depth of invasion (P = 0.03), nodal metastasis (P = 0.04) and a higher American Joint Committee on Caner (AJCC) clinical stage (P = 0.009). Using western blot analysis, we confirmed the cell-specific up-regulation of Dicer protein in vitro. A pooled-analysis on mRNA profiling in cutaneous tumors showed up-regulation of Dicer at the RNA level in cutaneous melanoma, also showing deregulation of other enzymes that participate in the biogenesis and maturation of canonical miRNAs. CONCLUSIONS: Increased Dicer expression may be a clinically useful biomarker for patients with cutaneous melanoma. Understanding deregulation of Dicer and its influence on miRNA maturation is needed to predict the susceptibility of melanoma patients to miRNA-based therapy in the future

Lost generation: Reflections on resilience and flexibility from an energy system architecture perspective

Whole energy system modelling is a valuable tool to support the development of policy to decarbonise energy systems, and has been used extensively in the UK for this purpose. However, quantitative insights produced by such models necessarily omit potentially important features of physical and engineering reality. The authors argue that important socio-technical insights can be gained by studying critical events such as the loss of 2.1 GW generation from the electricity system of Great Britain on 9th August 2019, in conjunction with literature on the behaviour of complex systems. Among these insights is the idea that models of the operation and evolution of energy systems can never be complete. Both system behaviour (operation) and the emergence and evolution of structure in such systems are formally uncomputable. This provides a starting point for a discussion of the need for additional tools, drawn from the System Architecture literature, to support the design and realisation of future, fully-decarbonised systems with high penetrations of renewable energy. Desirable properties of System Architectures, including current and future Energy System Architectures, are discussed. These include resilience and flexibility, for which there is an extensive literature. They also include the properties of comprehensibility, which helps to make complex systems easier to operate, and of evolvability, for which a working definition is offered

La Teleriabilitazione durante la pandemia da COVID-19: un’indagine dell’Ontario Physiotherapy Association delinea vantaggi e criticità

Il governo dell’Ontario considera prioritaria l’integrazione della assistenza virtuale, per consentire una maggiore accessibilità alle cure da parte di utenti, spesso penalizzati da barriere sociodemografiche. A partire dal 27 aprile 2020 per 3 settimane, è stato condotto in Ontario un sondaggio intervistando 365 soggetti durante la pandemia Covid-19, per valutare l’esperienza maturata dai fisioterapisti con la Teleriabilitazione. Sono emersi vantaggi (continuità di cure, contenimento di costi e spostamenti da parte dei pazienti e criticità (insostituibilità della modalità in presenza per valutazioni o terapie manuali, esigenza di una adeguata alfabetizzazione digitale, scarsa disponibilità di adeguamento delle polizze assicurative). In conclusione, ribadita l’insostituibilità della modalità “in presenza” soprattutto per quel che concerne alcune procedure, la Teleriabilitazione si candida come una modalità utile a ridurre il peso sulle strutture ospedaliere, garantire continuità terapeutica, per la sua capacità di enfatizzare l’apprendimento, lo spirito cooperativo e la partecipazione attiva e consapevole del paziente