Holographic Renormalization of Foliation Preserving Gravity and Trace Anomaly

From the holographic renormalizationg group viewpoint, while the scale transformation plays a primary role in the duality by providing the extra dimension, the special conformal transformation seems to only play a secondary role. We, however, claim that the space-time diffeomorphism is crucially related to the latter. For its demonstration, we study the holographic renormalization group flow of a foliation preserving diffeomophic theory of gravity (a.k.a. space-time flipped Horava gravity). We find that the dual field theory, if any, is only scale invariant but not conformal invariant. In particular, we show that the holographic trace anomaly in four-dimension predicts the Ricci scalar squared term that would be incompatible with the Wess-Zumino consistency condition if it were conformal. This illustrates how the foliation preserving diffeomophic theory of gravity could be inconsistent with a theorem of the dual unitary quantum field theory.Comment: 18 pages, v2: reference added, v3: comments on more recent literature added in response to referee's reques

Advances in multispectral and hyperspectral imaging for archaeology and art conservation

Multispectral imaging has been applied to the field of art conservation and art history since the early 1990s. It is attractive as a noninvasive imaging technique because it is fast and hence capable of imaging large areas of an object giving both spatial and spectral information. This paper gives an overview of the different instrumental designs, image processing techniques and various applications of multispectral and hyperspectral imaging to art conservation, art history and archaeology. Recent advances in the development of remote and versatile multispectral and hyperspectral imaging as well as techniques in pigment identification will be presented. Future prospects including combination of spectral imaging with other noninvasive imaging and analytical techniques will be discussed

A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) consists of (1 → 6)-2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, O-acetylated at position C3 or C4. Glycomimetics appear attractive to overcome the CPS intrinsic lability in physiological media, due to cleavage of the phosphodiester bridge, and to develop a stable vaccine with longer shelf life in liquid formulation. Here, we generate a series of non-acetylated carbaMenA oligomers which are proven more stable than the CPS. An octamer (DP8) inhibits the binding of a MenA specific bactericidal mAb and polyclonal serum to the CPS, and is selected for further in vivo testing. However, its CRM197 conjugate raises murine antibodies towards the non-acetylated CPS backbone, but not the natural acetylated form. Accordingly, random O-acetylation of the DP8 is performed, resulting in a structure (Ac-carbaMenA) showing improved inhibition of anti-MenA CPS antibody binding and, after conjugation to CRM197, eliciting anti-MenA protective murine antibodies, comparably to the vaccine benchmark.Bio-organic Synthesi

The Italian National Register of infants with congenital hypothyroidism: twenty years of surveillance and study of congenital hypothyroidism

All the Italian Centres in charge of screening, diagnosis, and follow-up of infants with congenital hypothyroidism participate in the Italian National Registry of affected infants, which performs the nationwide surveillance of the disease. It was established in 1987 as a program of the Health Ministry and is coordinated by the Istituto Superiore di Sanità. The early diagnosis performed by the nationwide newborn screening programme, the prompt treatment and the appropriate clinical management of the patients carried out by the Follow-up Centres, and the surveillance of the disease performed by the National Register of infants with congenital hypothyroidism are the components of an integrated approach to the disease which has been successfully established in our country

Publisher correction: a stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Correction to: Nature Communications https://doi.org/10.1038/s41467-020-18279-x, published online 7 September 2020.The original version of this Article contained errors in Fig. 1. The label ‘a’ was omitted for the left panel and the label ‘b’ was omitted for the right panel. In Fig. 1b, the right parenthesis was incorrectly positioned indicating a 4-carbon linker, rather than the correct 6-carbon linker. These errors have been corrected in both the PDF and HTML versions of the Article.Bio-organic Synthesi

The GIADA experiment for ROSETTA mission to comet 46P/Wirtanen: Design and performances

Rosetta is one of the most ambitious missions planned by ESA for the beginning of the next millennium. It will explore from very close a comet nucleus along its trajectory up to perihelion. In the instrument complex forming the scientific payload, the GIADA (Grain Impact Analyser and Dust Accumulator) experiment is devoted to study the cometary dust flux evolution and grain dynamic properties. To achieve the required performances and the expected scientific return, GIADA has been designed as a multi-sensor instrument. It is able to detect grain passage by laser light scattering measurement, particle momentum through piezoelectric transducers and mass flux by means of quartz crystal microbalances. In this paper we describe the technical solutions and performances which have been reached on the development models of GIADA. (C) 1999 COSPAR. Published by Elsevier Science Ltd

The MAPEC_LIFE study (LIFE12 ENV/IT/000614): monitoring air pollution effects in children for supporting public health policy

The use of genetic biomarkers has been studied largely in adult population exposed to air pollution, but few studies have investigated genetic damage in children. The aim of the project is to evaluate the associations between the concentration of urban air pollutants and early biological effects in children. The study will be carried out on 1000 children 6-8 years old living in five Italian towns in two different seasons by analyzing two biomarkers of early biological effects: DNA damage detected with the comet assay and frequency of micronuclei in buccal cells. A questionnaire will be used to collect the details of children diseases, socio-economic status, exposures to other pollutants and life-style. Ultra-fine particulate samples (PM 0.5) collected in the school areas will be analyzed for PAHs and nitro-PAHs concentrations, lung toxicity and in vitro genotoxicity on bacterial and human cells. All data will be statistically tested to investigate the possible associations between levels of air pollutants, air mutagenicity and early effect biomarkers. The final purpose of the project will be to elaborate a model for calculating the global absolute risk of early biological effects